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The Blood Type Diet Archives Volume 10




ALCAT does not typically correlate with ER4YT

Posted By: Peter D'Adamo
Date: Thursday, 29 July 1999, at 11:59 a.m.

In Response To: Alcat and IBS question; please reply (Andrea Cayea A)

As much as the proponents of ALCAT would like it to, as they are somewhat supportive of my work. Lectin reactions do not typically cause the manifestation of allergy, though some do. (See Below) The ALCAT test is not a typical allergy test, but rather more like a cytoxic test.

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Eur J Immunol 1999 Mar;29(3):918-27

Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils.

Haas H, Falcone FH, Schramm G, Haisch K, Gibbs BF, Klaucke J, Poppelmann M, Becker WM, Gabius HJ, Schlaak M

Forschungszentrum Borstel, Germany. hhaas@fz-borstel.de

Dietary lectins, present in beans and other edible plant products, pose a potential threat to consumers due to their capacity to induce histamine release from basophils. In this study, we analyzed the capacity of 16 common, in particular dietary, lectins to induce human basophils to secrete IL-4 and IL-13, the key promoters of Th2 responses and IgE synthesis. Several of the lectins, especially concanavalin A, lentil lectin, phytohemagglutinin, Pisum sativum agglutinin and Sambucus nigra agglutinin, triggered basophils to release IL-4 at concentrations of up to 1 ng/10(6) basophils. Lectins with high IL-4-inducing capacity also stimulated the release of IL-13 and histamine. Lectin-induced IL-4 and IL-13 release reached a maximum after 4-6 h and more than 18 h, respectively. Affinoblotting revealed that lectins with the capacity to induce mediator release bind to IgE, suggesting IgE binding as initial step of signal generation. In conclusion, several dietary lectins can trigger human basophils to release IL-4 and IL-13. Since lectins can enter the circulation after oral uptake, they might play a role in inducing the so-called early IL-4 required to switch the immune response towards a Th2 response and type I allergy.


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