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The Blood Type Diet Archives Volume 8




Coleus, NMDA, Polyamines, NO and Marcel Duchamp

Posted By: Peter D'Adamo
Date: Thursday, 4 February 1999, at 4:09 a.m.

In Response To: Re: Coleus forskolii for a vegan Type O (Joan (O))

Hi Joan

Coleus has a mild 'positive ionotropic' effect at the NMDA receptor, related to second messenger (cAMP) activation. This effect also conveys the mild hypotensive effect sometimes observed with its traditional use in Ayurveda.

Interestingly, polyamines (linked to dietary lectins), principally spermidine, also have modulatory effect on the NMDA receptor by regulating nitric oxide production, probably by facilitating intracellular mRNA.

NO is also linked thru ABO polymorphism; apparently the presence of a B antigen (i.e blood types B and AB) allows for improved recycling of citrulline and arginine back into NO. Although the researchers have said that the cause is unknown, you know that I suspect it is through the effects of gene linkage between the ABO locus and the locus for argininyl sulfosuccinase, both on 9q34.

Still, I think if you are type O, you're better off with the protein.

"There are no solutions, because there are no problems."
-Marcel Duchamp


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