Hi Bob, When you give blood sample you should simply request that the lab conducts an additional test called PSA ratio of "free-to-total ". Nothing too complicated about it because this test had been available since '90. There are numerous studies that link this ratio to incidents of cancer. Essentially, if ones total PSA is from 3-10, and the ratio is more than 25%, than biopsy may not be required and there is a good chance that the problem is caused by BPH rather than cancer. If the ratio is less than 25% there is 90% chance that there is cancer. I have those papers on my files and if interesting I can send those to you. In fact, I had sent you one already - from: ARUUP Hybrytech. PS There are many internet sites (Mediconsult.com; USSTOO etc) with very valuable info on the PC detection and treatments. Let me know what you think.