TABLE OF CONTENTS

• Ask the Doctor: Q & A by Peter J. D'Adamo, ND, MIfHI
• In Practice: Dr. Ginger Nash discusses SWAMI GenoType™
• Two New Studies Support Dr. D’Adamo’s Work
• Change Your Genetic Destiny: (New Softcover Release)
• March Monthly Support Group Information
• Barbara Shola,, Office Manager
• Facebook: Blood Type and GenoType Groups are Sprouting Up
• Recipes: Breakfast of Champions

Q: How did you determine which foods would be appropriate to each GenoType? A: To determine the foods for each GenoType, I condensed huge amounts of information into massive data files. These include, to name a few, the mammoth USDA SR19 Nutrient Database and most of its adjuncts (such as the antioxidant, isoflavone, flavone and choline metabolites); all of the lectin databases; the Blood Type Diet values, all available data on ‘alternative’ food values such as food contamination, allergens, chitinase, pesticides, gluten, carbohydrate breakdown values, etc.

Each diet is different because I looked for foods and supplements that nourish and cleanse your cells, ensure the health of your organs, or restore the cell’s ability to respond properly to the body’s hormone messages. These foods act as cellular medicine. Through cellular medicine, you can begin to repair the damage that has accumulated through years of poor behavior.

Q: I am generally in good health. By following this diet, how do I know that I am not turning on the bad genes?

A: Eating and exercising the right way will keep the right genes talking while gently encouraging the wrong ones to quiet down. But because you’ve got a unique genetic inheritance, you need the diet and exercise plans that are right for you. The strategies that work for your spouse, your friend, or even your parents might be harmful for you. This is what I call genetic medicine, and it is the first aspect of the GenoType program because it’s literally designed to reprogram your genes’ responses. Accordingly, I’ve developed individualized diet plans for each GenoType, emphasizing the foods and supplements that will work best to silence some genes and turn up the volume on others, creating optimal health, weight, and vitality. Since every one of your body’s functions ultimately begins with your genes, genetic medicine is the deepest and longest-lasting force for change. It’s the fastest way to get those positive changes under way and the surest way to hold on to your gains.

Peter D’Adamo, ND

SWAMI GenoType is a sophisticated dietary analysis and reporting software program that Dr. D’Adamo designed for clinical practice. His colleague, Dr. Ginger Nash, has been using SWAMI GenoType to construct personalized nutritional guidelines for her patients for three years and feels that the individualized approach through SWAMI GenoType has been particularly beneficial.

“It has given me the tools to create completely specific diets for people with various conditions, with differing inherited weaknesses or strengths based on vast amounts of nutritional information.” Dr. Nash explains.

Dr. Nash has been using SWAMI GenoType since its inception, about 3 years ago, and says that it has become, “an invaluable part of my work, allowing me to use diet as medicine.”

She cites weight loss, improved energy and strength, better skin and digestive function and improved overall health as common benefits of following your personalized diet. She also has patients with an entire spectrum of health issues; from those who are treating cancer, to those who want to optimize their already good health.

According to Dr. Nash, chronic conditions such as eczema and psoriasis, hormonal imbalances like PMS and thyroid dysfunction and digestive problems like irritable bowel syndrome and colitis seem to respond very well to this nutritional approach.

The SWAMI GenoType process involves working with the patient on a personal health history, biometric testing, breath hydrogen testing, blood testing and a number of other health factors and goals. SWAMI GenoType can be further customized to reflect the patient’s preferences, such as Kosher or vegetarian. Once the process is complete, a fully customized book is created that includes, food lists, meal plans and recipes.

Here are two studies which support individualized nutrition and the work and research that Dr. D’Adamo has been doing. We’ll be seeing more work like this as the validity of ABO as a significant biometric marker becomes more accepted in the scientific and medical communities.

Large-scale genomic studies reveal central role of ABO in sP-selecti and sICAM-1 levels.

Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, Nambi V, Bretler M, Smith NL, Peters A, Lu C, Tracy RP, Aleksic N, Heeriga J, Keaney JF Jr, Rice K, Lip GY, Vasan RS, Glazer NL, Larson MG, Uitterlinden AG, Yamamoto J, Durda P, Haritunians T, Psaty BM, Boerwinkle E, Hofman A, Koenig W, Jenny NS, Witteman JC, Ballantyne C, Benjamin EJ.

Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX.

P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting soluble levels of P-selectin (sP-selectin) and ICAM-1 (sICAM-1), we performed a genome-wide association study (GWAS) in a sample of 4,115 (sP-selectin) and 9,813 (sICAM-1) individuals of European ancestry as a part of The Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) consortium. The most significant SNP association for sP-selectin was within the SELP gene (rs6136, p=4.05x10(-61)) and for sICAM-1 levels within the ICAM-1 gene (rs3093030, p=3.53X10(-23)). Both sP-selectin and sICAM-1 were associated with ABO gene variants (rs579459, p=1.86 x10(-41) and rs649129, p=1.22X10(-15), respectively) and in both cases the observed associations could be accounted for by the A1 allele of the ABO blood group. The absence of an association between ABO blood group and platelet-bound P-selectin levels in an independent subsample (N=1,088) from the ARIC study, suggests that the ABO blood group may influence cleavage of the P-selectin protein from the cell surface or clearance from the circulation, rather than its production and cellular presentation. These results provide new insights into adhesion molecule biology.
http://www.ncbi.nlm.nih.gov/pubmed/20167578

Interindividual differences in response to plant-based diets: implications for cancer risk.

Lampe JW.

Fred Hutchinson Cancer Research Center and Nutritional Sciences Program, Department of Epidemiology, University of Washington, Seattle, WA, USA. jlampe@fhcrc.org

Genetic differences in taste preference, food tolerance, and phytochemical absorption and metabolism all potentially influence the effect of plant-based diets on cancer risk. Diet is a mixture of carcinogens, mutagens, and protective agents, many of which are metabolized by biotransformation enzymes. Genetic polymorphisms that alter protein expression or enzyme function can modify risk. Genotypes associated with more favorable handling of carcinogens may be associated with less favorable handling of phytochemicals. For example, glutathione S-transferases detoxify polycyclic aromatic hydrocarbons and metabolize isothiocyanates, which are chemopreventive compounds in cruciferous vegetables. A polymorphism in the GSTM1 gene results in lack of GSTM1-1 protein. Pharmacokinetic studies suggest that lack of GSTM1 enzyme is associated with more rapid excretion of the isothiocyanate sulforaphane; therefore, individuals who have this genetic variation may derive less benefit from consuming cruciferous vegetables. Flavonoids are conjugated with glucuronide and sulfate and are excreted in urine and bile. Polymorphisms in UDP-glucuronosyltransferases and sulfotransferases may contribute to variability in phytochemical clearance and efficacy. Genetic polymorphisms in enzymes that metabolize phytochemicals may account in part for variation in disease risk and also have to be considered in the context of other aspects of human genetics, gut bacterial genetics, and environmental exposures.
http://www.ncbi.nlm.nih.gov/pubmed/19297461

Dr. D’Adamo’s GenoType® Diet has just been released in paperback with a new cover and a new name, Change Your Genetic Destiny, The Revolutionary GenoType® Diet. Although the look and title are different, the book contains the same groundbreaking information and cutting-edge science as the original. Start your year off “right” with diet and exercise plans that will forever change the way you look at food.

Event: D’Adamo Personalized Nutrition Support Group Meeting Date: Thursday, March 18 Time: 5:30pm – 6:30pm Topic: Spring into Health - Celebrate the New You Host: Nancy Kuhn Place: D’Adamo Personalized Nutrition Store 213 Danbury Road Wilton, CT 06897 Our "Know Better" support group presents guest speaker, Dr. Roseanne Nenninger, ND, North American Pharmacal’s very own in-house doctor. Dr. Nenninger will give us a fascinating inside look into how she uses the Blood Type Diet in her private practice. As seating is limited, please RSVP to nancy@dadamo.com or call (877) 226-8973

For almost two years, Barbara Shola has been coordinating the busy days at the Center for Personalized Medicine. In between answering phones, scheduling appointments for two doctors and assisting patients, Barbara also manages the office with the ease and efficiency of a pro! She says she loves working with the patients and with the staff at the Clinic. “It’s all about the patients and providing great service.” She says with a smile.

Barbara’s skills are not limited to administrative duties; she is also a licensed mental health counselor. Prior to working at the Center for Personalized Medicine, she worked with an outpatient group as an art therapist and as a crisis counselor in a domestic violence shelter. Barbara continues to maintain her license and pursues continuing education in the field. She believes that the work continues even though she is no longer actively counseling. “Ultimately, I feel that we deal with mental health issues to some degree on a day-to-day basis as part of the human condition of being.” Barbara was not familiar with Dr. D’Adamo’s theories until she began working at the clinic, but says that as she began speaking to patients early in her tenure, she heard many stories of patients who claimed that Dr. D’Adamo “saved their life.” She explains, “That was and continues to be a very positive reaction for me.” Barbara is a blood type O, who follows the Hunter GenoType Diet and feels that eliminating wheat from her diet has been a great benefit for her overall health. Please call the clinic if you are interested in scheduling an appointment.

There are several groups sprouting up regarding the Blood Type Diet. You can find them by going to www.facebook.com and doing a search. This is Dr. Peter D’Adamo’s group: Blood Type Diet / Eat Right For Your Type Here’s a group based in London: The Blood Type Diet This group is based in Montreal, Canada: Blood Type Diet A new group out of New York has just started up. “We are interested in the Genotype and Bloodtype diets as published by Dr. Peter D’Adamo. We get together monthly in Manhattan for informal discussions. Come on down: learn new information, talk the ‘language’, and share experiences!” NYC Genotype Diet Group This group is based in Boise, ID The GenoType Diet This group is based in Los Angeles, CA Genotype Diet

ALL GENOTYPES: Nutty Fruity Breakfast Quinoa