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BTD Forums  /  The Encyclopedia/ D'Adamo Library  /  inverse association between cancer and Alzheimer's
Posted by: Chloe, Thursday, April 10, 2014, 5:48pm
http://www.medicalnewstoday.com/articles/275373.php#rate

http://www.newscientist.com/article/mg21929254.400-why-cancer-protects-from-alzheimers-and-vice-versa.html#.U0bZvCjRe0s

Alzheimers more likely in women over 60 than breast cancer
http://www.cnn.com/2014/03/19/health/women-alzheimers/
Posted by: Spring, Thursday, April 10, 2014, 7:42pm; Reply: 1
Wow, those comments on the article at CNN were emotional to say the least. If I were some of those people I wouldn't be getting all riled up so about the difference in the percentages of men and women getting AD. I've seen more men die with brain cancer than women, and that is really awful too. Whatever the percentages, AD is a very horrible disease for anyone. I know one man, though, who has been brilliant and successful in every way but has in the last couple of years been diagnosed with AD. It devastated him and his family, but his doctors have him on all kinds of alternative treatments, and he has shown considerable improvement even though it had been very progressive. I have read articles about ways people can keep their minds active doing different things to help avoid AD, but this man was an inventor whose mind was forever inclined toward inventions of one sort or another and had the patents and royalties to prove it. He was and still is more active than anyone his age I know, but it didn't spare him from AD.

I've known people who were more forgetful nearly than anybody, but they never got AD. There just doesn't seem to be any rhyme or reason for who will get it.
Posted by: Chloe, Thursday, April 10, 2014, 8:01pm; Reply: 2
scary....40 years ago when DDT was being used, then banned....well, it's still lingering in the environment....in people's bodies...

http://www.scientificamerican.com/article/studies-link-ddt-other-environmental-toxins-to-late-onset-alzheimers-disease/
Posted by: Spring, Thursday, April 10, 2014, 10:42pm; Reply: 3
My dad used DDT like it was "going out of style" which it certainly was, and he never had any mental problems at all unless using DDT was a symptom! But, of course, back then when they first started using the stuff, people didn't know how long-lived it was and how terrible it was for their health. Of course, that was over fifty years ago.  People had better food in those days, though, than we do now. The land was not so worn out. I never knew anyone who used DDT on food crops.
Posted by: Chloe, Friday, April 11, 2014, 12:53am; Reply: 4
Quoted from Spring
My dad used DDT like it was "going out of style" which it certainly was, and he never had any mental problems at all unless using DDT was a symptom! But, of course, back then when they first started using the stuff, people didn't know how long-lived it was and how terrible it was for their health. Of course, that was over fifty years ago.  People had better food in those days, though, than we do now. The land was not so worn out. I never knew anyone who used DDT on food crops.


Based on how each genotype detoxes environmental pollution and other poisons, it's likely  your dad could clear toxins easily. DDT didn't stay in his system...and then of course, there must
be a genetic predisposition for some to get AD and others, not.. Why was your dad using so much
DDT?  It seems more related to cancer than neuro degenerative diseases.

DDT was one of the first chemicals in widespread use as a pesticide. Following World War II, it was promoted as a wonder-chemical, the simple solution to pest problems large and small. Today, nearly 40 years after DDT was banned in the U.S., we continue to live with its long-lasting effects:

Food supplies: USDA found DDT breakdown products in 60% of heavy cream samples, 42% of kale greens, 28% of carrots and lower percentages of many other foods.
Body burden: DDT breakdown products were found in the blood of 99% of the people tested by CDC.
Health impacts: Girls exposed to DDT before puberty are 5 times more likely to develop breast cancer in middle age, according to the President’s Cancer Panel.


http://www.panna.org/issues/persistent-poisons/the-ddt-story



Posted by: Spring, Friday, April 11, 2014, 4:50am; Reply: 5
It wasn't as if he actually used so much of it because it was so "effective" he didn't have to, but he used it for any known bug around, especially termites. There has never been any breast cancer even in my extended family.

Of course, anywhere cotton was grown planes were flying around spraying the stuff right and left to fight the boll weevil. Ironically, there is one town somewhere in the South that has a statue honoring the boll weevil. The reason being that it put the farmers out of the cotton business into growing peanuts. So, at least, that farmland did not get ruined with DDT. Actually, the farmers had no idea how much they really did owe the boll weevil even though at first they thought they were going to go broke. They may have owed the little rascals their lives!
Posted by: KimonoKat, Friday, April 11, 2014, 9:03am; Reply: 6
I thought O's were more susceptible than other blood types. No?  ??)
Posted by: susanC, Friday, April 11, 2014, 6:28pm; Reply: 7
Very interesting Spring. So now they're growing peanuts in the soil that was heavily sprayed with DDT?
Posted by: Spring, Friday, April 11, 2014, 6:51pm; Reply: 8
Quoted from susanC
Very interesting Spring. So now they're growing peanuts in the soil that was heavily sprayed with DDT?


No, they were already put out of business by the time DDT came along.
Posted by: Jane, Friday, April 11, 2014, 7:34pm; Reply: 9
Interesting.  I didn't know that.   My mother had AD.  My father ended up with colon cancer but kept working as a hydraulic engineer until the day he died.  My mother was a stay at home mom.  I think my father's work, some of which was groundbreaking, kept him young.  He had associates all over the world and he was a great networker.  My mother's world was very small.  
Posted by: Chloe, Friday, April 11, 2014, 8:05pm; Reply: 10
Poisons like DDT and other environmental pollution are the very things that
turn a genetic predisposition for a disease into an actual disease. There is a switch that gets turned
on for some people exposed to particular poison...but not everyone is vulnerable to same toxicity.

The oddest thing for me is that we moved from NY to Atlanta, Georgia when I was 7...My mother was diagnosed with Hodgkins Lymphoma when I was 9, less than 2 years after my youngest sister was born.  She lived for 12 years with it... So, here's what I find curious...Within a 2 mile radius of where we lived, 3 women were diagnosed with hodgkins Lymphoma...2 died before my mother did.  Many of my mother's friends had cancer...Many of our neighbors had cancer.  I would have loved to have figured out the common denominator....a virus spread through our drinking water? ....was something sprayed from airplanes to kill pests?....was the government doing experiments.?..WHY would 3 women have the same type of cancer living  in such close proximity?  My sisters and I keep thinking that something was in our drinking water. Something that was covered up.
Posted by: Averno, Friday, April 11, 2014, 10:05pm; Reply: 11

They sprayed it everywhere, even in suburban communities to control mosquitos.  There were public service TV spots showing children running behind the vehicles in the fog.

It's still sanctioned by the WHO for use in Africa to reduce malaria, it's original intended use. Better sick than dead, I guess...  ::)


Posted by: Spring, Friday, April 11, 2014, 10:35pm; Reply: 12
Quoted from Chloe
  My sisters and I keep thinking that something was in our drinking water. Something that was covered up.


I think "covering up" is still alive and well in this country as we write. I remember only too well how Rachel Carson was hated. Everything she said was true.
Posted by: Chloe, Tuesday, April 15, 2014, 9:32pm; Reply: 13
http://people.csail.mit.edu/seneff/alzheimers_statins.html

Not sure if this link is relative to the subject header, but I find it totally fascinating that a few years
after my daughter in law's mother was put on statins, her memory became fuzzy.  It's been 6 years
since she started statin drugs to lower her mildly elevated cholesterol ...(and although I've sent the family articles like this before, the PCP
who prescribed this drug does not see a connection)....so she is still on the drug....is now 82 with a definitive diagnosis of Alzheimers...She's ready to be living either with full time help at home or in a facility that specializes in this disease.  She's blood type O which this article states that AD could have an h pylori connection. Infection related.  Wonder if studies have been done on people who have
AD and H pylori...  This poor woman was always so vain and conscious of her weight that she ate an almost fat free diet.....egg white omelets, salads without dressing, food cooked without fat. Also
ate a lot of wheat....dry toasted bagels...fat free cream cheese..  Her belief was always that fat caused fat bodies.  Doesn't seem possible that her diet and statins caused her AD diagnosis, but sadly it appears very likely that there could be a connection.
Posted by: C_Sharp, Tuesday, April 15, 2014, 11:43pm; Reply: 14
Quoted from Chloe
This poor woman was always so vain and conscious of her weight that she ate an almost fat free diet.....egg white omelets, salads without dressing, food cooked without fat.


I did fat free for a while until my mother pointed out that the brain was 60% fat.
Posted by: jeanb, Wednesday, April 16, 2014, 1:56am; Reply: 15
The APOE4 gene seems to travel down the female lines in my family.  I inherited the gene from my mother.  

My mother, her sister and their mother all suffered from Alzheimer's.  My grandmother spoke 7 languages, my mother and her sister had very full lives and careers. Interesting to note my brother and my sons didn't inherit the APOE4 gene.

None of the men in my maternal family suffered from the disease.  Only 1 female relative we can trace survived the war into old age.  She recently died of AD at the age of 87.  Her son did not inherit the gene.  

My bet is that APOE4 is one factor, in my family, it travels in the female genetic make-up.  My guess, for my mother's generation, the smoking, lack of exercise and other factors may have turned it on.  My grandmother had rheumatic fever as a child and ended up with serious heart issues in her mid 60's, she also had her first baby when she was 16 and had a hard life, which may or may not have contributed to AD.  

I do wish there was an easy do this, don't do that answer for AD, but I suspect it is far more complex problem to solve.
Posted by: Jane, Wednesday, April 16, 2014, 4:07pm; Reply: 16
Jeanb, Interesting comments.  My mother never had genetic testing.  She was 93 when she died and did have AD. She was diagnosed by a neuologist after some back surgery. Her brother who is in his late 80s was recently diagnosed with dementia.  My mother led a very sedentary life, didn't work outside the home most of her life.  I've often thought that her world was too small and didn't challenge her sufficiently.

It's such a sad disease.  I felt like I was robbed of my mother at least 10 years before she finally passed away.  
Posted by: Chloe, Wednesday, April 16, 2014, 4:29pm; Reply: 17
Quoted from jeanb
The APOE4 gene seems to travel down the female lines in my family.  I inherited the gene from my mother.  

My mother, her sister and their mother all suffered from Alzheimer's.  My grandmother spoke 7 languages, my mother and her sister had very full lives and careers. Interesting to note my brother and my sons didn't inherit the APOE4 gene.

None of the men in my maternal family suffered from the disease.  Only 1 female relative we can trace survived the war into old age.  She recently died of AD at the age of 87.  Her son did not inherit the gene.  

My bet is that APOE4 is one factor, in my family, it travels in the female genetic make-up.  My guess, for my mother's generation, the smoking, lack of exercise and other factors may have turned it on.  My grandmother had rheumatic fever as a child and ended up with serious heart issues in her mid 60's, she also had her first baby when she was 16 and had a hard life, which may or may not have contributed to AD.  

I do wish there was an easy do this, don't do that answer for AD, but I suspect it is far more complex problem to solve.



I am APOe 3/4....so far, my brain is working fine. :)  Nobody in my family ever had the slightest signs of memory loss...Nobody but me ever followed a diet for my blood type.  I agree, it's
not
a simple problem to solve.

Posted by: jeanb, Wednesday, April 16, 2014, 4:39pm; Reply: 18
Hi Chloe and Jane:

Dr. D. posted something on Facebook about women, APOE4 and persistence of the disease in women after I posted, I haven't had a chance to read the article thoroughly, but it does show some correlation about being female and APOE4 and AD.

As I watch my mother go through AD, my sister, the home and I are all watching my mom's physical health improve (no medications - her high blood pressure, cholesterol and thyroid issues have all resolved themselves) as her AD symptoms become worse and worse.  My sister and I wonder if we should perhaps check into all inclusive resort style living  - stress free and see if our physical aches and pains go away and if the brain disintegrates....
Posted by: Jane, Wednesday, April 16, 2014, 5:53pm; Reply: 19
jeanb....I'm in with the all inclusive LOL.  
My mother had some health issues but had no cancers that I'm aware of.  She had thyroid issues which I now believe were undertreated and she had some digestive issues, a hiatal hernia which was so large that she was told it was inoperable when she was younger.There were at times it was so bad that she bled internally.  Her hematocrit was so low that they had to give her blood.  I saw confusion from that as well.  There are just so many things that I guess we still don't know.  Dementia really got much worse after her extensive back surgery - two procedures and I think she was out too long - more than 6 hours if I remember correctly.  She was diagnosed with AD while in rehab for her back.
Posted by: Chloe, Wednesday, April 16, 2014, 6:32pm; Reply: 20
Interesting statistics

Alzheimer’s and dementia is most common in Western Europe (North America is close behind)
Alzheimer’s is least prevalent in Sub-Saharan Africa. (Alzheimer’s Disease International)



I guess we need to study the people of sub Saharan Africa.
Posted by: Jane, Wednesday, April 16, 2014, 7:41pm; Reply: 21
Maybe the numbers are skewed by how long people live, availability of healthcare and diagnosis????
Posted by: Chloe, Wednesday, April 16, 2014, 8:42pm; Reply: 22
Quoted from Jane
Maybe the numbers are skewed by how long people live, availability of healthcare and diagnosis????


Sounds very plausible.
Posted by: Chloe, Thursday, April 17, 2014, 5:04pm; Reply: 23
worth sharing

http://www.medicalnewstoday.com/articles/261025.php
Posted by: Captain_Janeway, Thursday, April 17, 2014, 6:16pm; Reply: 24
I know two people who have this disease one a community college president who was a good friend of my father died recently and the other is a very talented and intelligent  woman in our church who played the organ and could sing beautifully. So sad to see this disease ravage its victims.

I have heard that there is a "high functioning" form of this disease and it often occurs in seniors who have an above average IQ. But most people that I have known with this disease are normal or well above normal in intelligence. I guess it doesn't discriminate regards its victims.
Posted by: C_Sharp, Thursday, April 17, 2014, 6:35pm; Reply: 25
Quoted from Captain_Janeway
But most people that I have known with this disease are normal or well above normal in intelligence. I guess it doesn't discriminate regards its victims.


This is also true in my experience. I have wondered whether in fact that people with high intelligence are more likely to get Alzheimer's. Perhaps something that makes them "bright" at an earlier age also makes the susceptible to the disease at a later age.

But it may also be that as a college professor the people that I know well are more likely highly intellectual people.




On your high functioning comments, I have communicated with some health care workers about people passing mental exams when it is obvious they have lost the mental capabilities they once had. They responded that if you start at a very high level, you may still pass their tests even with significant deterioration (Sort of a more distance to fall argument).




I have not looked for studies to backup either conjecture.
Posted by: Spring, Thursday, April 17, 2014, 10:57pm; Reply: 26
I have known some who functioned regularly in certain complicated situations up until the time of their death with no problem whatsoever, but they hardly recognized their own spouse or had any memory about what had happened in the last five minutes. It is incredible and yet so sad. Some have died of other causes before they got to that state. Others have become like a vegetable who couldn't even swallow a long time before they died. It is possible for some with fairly severe cases who have lucid moments sometimes. The ones I have known like that are aware that something is dreadfully wrong with their brain and the horror of it is devastating to them. But just as quickly it will fly away. Maybe it is a mercy that it does...
Then there are plenty of other people I have known who lived to be in their nineties, and they were as bright as they ever were until their death. Thankfully, a lot more of them than those with AD. A lot more.
Posted by: Chloe, Thursday, April 17, 2014, 11:22pm; Reply: 27
My daughter in law gave Trehalose complex to her mother, but don't think she remembered to take
very much of it.  She's declined horribly in this past year.  I saw her a few months ago....Thanksgiving...she asked me what we were doing when we were sitting together peeling sweet
potatoes...She watched what I was doing because something as simple as peeling skins off warm
potatoes was confusing for her....and yet hours later, she told me this long involved story with every
detail....and then a month later I saw her for our granddaughter's dance performance of the Nutcracker. At first she said "My granddaughter is dancing tonight"....(and of course, this is my granddaughter too)...She was confused by our relationship to one another.  And after the performance
came over to me and said "Aren't you proud of our awesome granddaughter?"  Wasn't sure if she meant mine and hers or hers and her husbands....After the performance we went out to dinner with
all the parents of the performers. It was a chaotic scene in a crowded place....She walked in and
said "why are we here?"  I said "to eat dinner"....We sat down at the table....she asked me to order
for her...She reads the menu but it's meaningless...I ordered her what  I ordered for me...salmon on a bed
of greens... I knew she liked that.  The food arrived....she looked at me and said "Did I order dinner?"
I said "yes, this is it"...OK, so she ate....and then went on to tell me a long involved story about friends of hers from her childhood.  So past memories....she doesn't skip a beat...names, dates,
locations...In the moment, foggy.  Yet she looks great, styles her hair, puts on her makeup and
goes to art classes.  Doesn't drive anymore because she gets lost.  Friends pick her up....but last
week, she hit the toaster oven button each time the toast was ready.   Fire in the kitchen....Her
husband who is 89 doesn't realize he can't take his eyes off her.  It's just sad.  We love our DIL's
parents....She still recognizes me....although last week, my DIL said she saw a photo of her oldest
son who lives in CA and asked who he was....:(
Posted by: Averno, Friday, April 18, 2014, 1:10pm; Reply: 28

My mother's trajectory began with depression after my father's death and ended with breast cancer in the AD ward of a nursing home 14 years later. She'd been a gifted artist and pianist with an IQ of 150. Her's was the classic story, from increasingly troubled memory to complete disassociation. While in the ward, her general health actually improved... she forgot her smoking habit, and was provided a more balanced diet. She ate foods that she'd always had a strong aversion to- broccoli, spinach, fish, etc.

I do often wonder if those two things plus the fact that she'd been handling paint and turpentine for 60 years was her undoing.


Posted by: Chloe, Friday, April 18, 2014, 4:14pm; Reply: 29
Quoted from Averno

My mother's trajectory began with depression after my father's death and ended with breast cancer in the AD ward of a nursing home 14 years later. She'd been a gifted artist and pianist with an IQ of 150. Her's was the classic story, from increasingly troubled memory to complete disassociation. While in the ward, her general health actually improved... she forgot her smoking habit, and was provided a more balanced diet. She ate foods that she'd always had a strong aversion to- broccoli, spinach, fish, etc.

I do often wonder if those two things plus the fact that she'd been handling paint and turpentine for 60 years was her undoing.



Sorry to hear about your mom..:(
Interesting you mentioned paint and turpentine because my DIL's mother is an artist and has been doing oil painting for decades.  In the past few years she switched to acrylics..but up until about 12 years ago was a
heavy smoker.
Posted by: Averno, Friday, April 18, 2014, 8:33pm; Reply: 30
Quoted from Chloe


Sorry to hear about your mom..:(
Interesting you mentioned paint and turpentine because my DIL's mother is an artist and has been doing oil painting for decades.  In the past few years she switched to acrylics..but up until about 12 years ago was a
heavy smoker.


Thank you, Chloe

Artist colors are full of heavy metals and other toxins. Oils and acrylics. It amazes me that any artist reaches old age.

Posted by: Chloe, Friday, April 18, 2014, 8:45pm; Reply: 31
Quoted from Averno


Thank you, Chloe

Artist colors are full of heavy metals and other toxins. Oils and acrylics. It amazes me that any artist reaches old age.



I'm an artist, but, my current tools are all hon toxic water soluble colored pencils. Haven't used oils or acrylics since college.  The odors made me feel sick.

A total segue.....the sick mind and Van Gogh cutting off his ear....wondered about the origin of that story....was it true?  Had he gone mad from his toxic paints?

http://www.physicsforums.com/showthread.php?t=10432


Posted by: Spring, Saturday, April 19, 2014, 3:17am; Reply: 32
Well, my DMIL was an artist for decades, and she was totally "with it" until just minutes before her death. Some of her paintings were huge so she had plenty of opportunities to breath a world of toxins.  So it really is a mystery, isn't it?
Posted by: Chloe, Saturday, April 19, 2014, 5:40pm; Reply: 33
http://www.medicalnewstoday.com/articles/275582.php
Posted by: Amazone I., Thursday, April 24, 2014, 7:49am; Reply: 34
I think we need to clarify... it's all about *adult stem cells* ;) :D... :X(whistle)
Posted by: Chloe, Tuesday, July 22, 2014, 7:09pm; Reply: 35
Just updating with new links I found that might be helpful for anyone searching for alzheimer's info.

http://www.medicalnewstoday.com/articles/261173.php
https://www.youtube.com/watch?v=Ls6VE3ZagUI
Posted by: misspudding, Tuesday, July 22, 2014, 7:25pm; Reply: 36
Interesting.

My dad's mom had dementia (maybe Alzheimers?) for a few years in her mid-80s. She passed at 86. She was a B.

Mom's mom's brain was perfect when she died. Lived alone until she died. Seems a combo of pills did her in (I blame the Paxil they briefly put her on that she hated and stopped taking...evil!). Also passed at 86. She was an A.

No cancer on either side of the family.

I'm kind of terrified about it since I'm an explorer with MTHFR issues (increases clots, decreases ability to detox), and I have a history of seizures and migraine with aura (dramatically increases risk of clots/stroke, which is of course, correlated with Alzheimers). All of my fingerprints are ulnar loops, too.

I do eat appropriately for my type, though. I think the big risk factors seem to be diabetes (they're calling Alzheimers Type III diabetes). My mom (O+ Explorer or Hunter, but probably Explorer) is type II diabetic. Dad is probably Explorer, too (O+, as well), but in perfect health (though is on Lipitor...evil!). They both eat plenty of gluten, which I think is also a huge risk factor if you're O or B.

Anyway, that's me talking out my arse...;)
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