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BTD Forums  /  Eat Right 4 Your Type  /  Secretly taking Metformin
Posted by: Tom Martens, Sunday, October 27, 2013, 6:05pm
So I was talking to my wife ( an AB) last night and she was complaining of having diarrhea.  I asked what she thought it was from and she said she thought it from the Metformin she was taking.  She went on to say she had noticed that when she ate starchy foods is when the digestive issues would flare up.

Needless to say I was shocked that she had been taking one of the Epigenetic compounds that Dr. D'Adamo had mentioned in his Trehalose Lecture but she had heard that it helped with slowing the aging process.  When I mentioned she ought to listen to Dr. D'Adamo's Trehalose Lecture she scoffed (as usual.)

Does anyone have any experience with Metformin besides Dr. D? Is it because it's MTOR dependent that the digestive issues occur?

Thanks.
Posted by: Lola, Sunday, October 27, 2013, 6:47pm; Reply: 1
Quoted Text
Dr D
http://www.ncbi.nlm.nih.gov/pubmed/24023728
metformin only decreases insulin resistance in the liver, not in the muscles as once thought.

Known agents that act on AMPK:
http://www.datapunk.net/quodlibet/quod-agents.pl...
Quodlibet Agents
http://www.datapunk.net
Posted by: Lola, Sunday, October 27, 2013, 6:48pm; Reply: 2
Quoted Text
Dr D
'Metformin intolerant cases more often belonged to blood group A and subgroup A Rh+, with 50% and 66% relative increases (P=0.0039 and P=0.0005),
respectively. '
What is the phenotype of patients with gastro... [Diabetes Metab. 2013] - PubMed - NCBI
http://www.ncbi.nlm.nih.gov
http://www.ncbi.nlm.nih.gov/pubmed/23786968
Posted by: Lola, Sunday, October 27, 2013, 6:51pm; Reply: 3
Quoted Text
Posted by: Lola, Sunday, October 27, 2013, 6:52pm; Reply: 4
Quoted Text
Dr D
Unusually among drugs to treat type 2 diabetes, metformin makes a difference to things that matter to patients and not just their numbers. It reduces illness and improves lifespan. In contrast the New Drugs for diabetes have not lived up to the promise of insulin and metformin and to an extent glibenclamide, though unlike metformin, glibenclamide causes hypoglycaemia.'
Great White Lies
davidhealy.org
http://davidhealy.org/great-white-lies/#sthash.M9q92237.dpuf
Posted by: Lola, Sunday, October 27, 2013, 6:53pm; Reply: 5
Quoted Text
Dr D
Any herb that contains berberine works in a manner akin to metoformin: By blocking MTOR via enhancing the activity of AMPK.
Posted by: Lola, Sunday, October 27, 2013, 6:54pm; Reply: 6
Quoted Text
Dr D
Berberine versus metformin in PCOS. Makes sense in light of their mutual effects in activating AMPK (and down-regulating MTOR). Should throw a little trehalose in there as well..
A clinical study on the short-term effect o... [Eur J Endocrinol. 2012] - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/22019891
Posted by: Lola, Sunday, October 27, 2013, 6:56pm; Reply: 7
Quoted Text
Dr D
Clue Found to Metformin's Anticancer Effect

Preclinical studies by Japanese researchers suggested that the diabetes drug metformin activates a protein that induces differentiation of stem-like glioma
cells to inhibit tumor growth.

The finding not only offers a possible therapeutic pathway in glioma, but also an explanation for metformin's apparent anti-tumor effect in numerous earlier
studies of breast, lung, ovarian, prostate, and colorectal cancer, among others.

Other researchers had shown that FOXO3 forces differentiation of stem-like/tumor-initiating cells in glioma. However, in the setting of established glioma,
FOXO3 is silenced by means of AKT- and ERK-mediated phosphorylation.

Evaluation of potential FOXO3 activators identified metformin as a promising candidate. In a report this week in Stem Cells Translational Medicine,
researchers confirmed that the drug activated FOXO3 through a different pathway, AMP-activated protein kinase.

"In mice studies, the administration of metformin had several benefits," Atsushi Sato, MD, PhD, of Yamagata University, said in a statement. "It depleted
the self-renewing and tumor-initiating cell population within established tumors, inhibited tumor formation by stem-like glioma-initiating cells in the
brain, and provided substantial survival benefit."
Posted by: Lola, Sunday, October 27, 2013, 6:57pm; Reply: 8
Quoted Text
Dr D
In the group with lung cancer, those who had used metformin alone had a different histology distribution than those who received neither metformin nor a
TZD, were more likely to present with metastatic disease.'

COMMENT: More evidence that mucking with mTOR and AMPK is good cancer medicine.
The effect of metformin and thiazolidinedione use on lung cancer in diabetics
http://www.biomedcentral.com
Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer.
Posted by: Tom Martens, Sunday, October 27, 2013, 7:25pm; Reply: 9
Wow, thanks Lola!
Posted by: Lola, Sunday, October 27, 2013, 9:14pm; Reply: 10
:)
Posted by: Goldie, Thursday, October 31, 2013, 11:44am; Reply: 11
A Different look at Metformin.....


I took it for years not telling any one.. The reason was that I did not want my know it all sis to tell me what to do..

Emotionally it is hard to accept diabetes as a label.. so much guilt and pointing fingers..

Cancer you get sympathy, diabetes you get grief...

As for your wife.. I feel for her,... she showed great trust in telling you about it.  took me to get very sugary during Cancer surgery to come clean..

I had constipation no matter what..

Be open to the following::::: I just spent hundreds of dollars for sups... I will need to spend many more hundreds of dollars, and that next to organic foods at a steep price.  

Metformin costs me nothing.  And all the Medical people will not make Me feel as If I am outside of norm! I get 'cover ' by my sis who believes doctors do no wrong.. her experiences are different from mine.. I can honor that..

As for your wife.. will she come here and read?  would she look at my threads with diabetes?  I would think about it and write some message just for her.. I might have some things to discuss just with her.. It would be about her being in charge of her life.  Her evalauation of what when where she can deal with things.

I do not like metformin as asuch, but for now I have no choices..   and for NOW i am testing my blood sugar and still have no clue what is going on..

My numbers which I never tested for are to high, and yet maybe they are also to low when i do nto eat often enough.. I wonder is she in the same kind of quandry?

there are no easy answers here..

For instance, I also have leg cramps for decades.. does she?

other issues that might be related to hypoglycemia?  woman might a little different here..  

age will matter, knowledge will matter....... and still after all is said and done.... I will have diabetes for LIFE... as will she..

my cancer is gone, I will do what I can to prevent it coming back, but that is way more easy compared to diabetes..

Diabetes is not dealt with well in society, husbands and sisters..

I would be pleased to talk to her.. a secrete admiror for her gutsyness to keep quiet.. dumb yes.. but I get it... say hi.. with love (and understanding) for everyone..  


  
Posted by: Tom Martens, Thursday, October 31, 2013, 1:34pm; Reply: 12
Quoted from Goldie
A Different look at Metformin.....


I took it for years not telling any one.. The reason was that I did not want my know it all sis to tell me what to do..

Emotionally it is hard to accept diabetes as a label.. so much guilt and pointing fingers..

Cancer you get sympathy, diabetes you get grief...

As for your wife.. I feel for her,... she showed great trust in telling you about it.  took me to get very sugary during Cancer surgery to come clean..

I had constipation no matter what..

Be open to the following::::: I just spent hundreds of dollars for sups... I will need to spend many more hundreds of dollars, and that next to organic foods at a steep price.  

Metformin costs me nothing.  And all the Medical people will not make Me feel as If I am outside of norm! I get 'cover ' by my sis who believes doctors do no wrong.. her experiences are different from mine.. I can honor that..

As for your wife.. will she come here and read? No would she look at my threads with diabetes? She does not believe in ERFYT (sort of) I would think about it and write some message just for her.. I might have some things to discuss just with her.. It would be about her being in charge of her life.  Her evalauation of what when where she can deal with things.

I do not like metformin as asuch, but for now I have no choices..   and for NOW i am testing my blood sugar and still have no clue what is going on..

My numbers which I never tested for are to high, and yet maybe they are also to low when i do nto eat often enough.. I wonder is she in the same kind of quandry?

there are no easy answers here..

For instance, I also have leg cramps for decades.. does she? She had muscle cramps in her back and legs that Magnesium took care of

other issues that might be related to hypoglycemia? no woman might a little different here..  

age will matter, knowledge will matter....... and still after all is said and done.... I will have diabetes for LIFE... as will she..

my cancer is gone nice! , I will do what I can to prevent it coming back, but that is way more easy compared to diabetes..

Diabetes is not dealt with well in society, husbands and sisters..

I would be pleased to talk to her.. a secrete admiror for her gutsyness to keep quiet.. dumb yes.. but I get it... say hi.. with love (and understanding) for everyone.. she said she was taking it because it helped with aging- not knowing the "how and why's" that Dr. D'Adamo has graciously explained.  I doubt she will ever come here to get information.  She does however use the Proberry and Genoma Security when sickness looms ;)


  


Posted by: Goldie, Thursday, October 31, 2013, 3:40pm; Reply: 13
see I am not looking to say anything about the diet.. just about what and hw she is doing.. much more important.. but you can only invite her to read my previous post.. all the best..
Posted by: Amazone I., Thursday, October 31, 2013, 3:56pm; Reply: 14
would give a try to or ABM and also Cprinus comatus...espec. whil in combo with diabetes;) .. :D but the very best is... Goldie test yourselve and the pilzli whith what kind of pilzli you're going into resonance... must be honest all do have very similar duties to fulfill with our bodies as agents... but there must bve a special reaction upon the one you're going to need.... :D perhaps even Chaga might be one of the next options ??) !!! ...wish you luck and all the best....(smile)
Posted by: Christopher1, Thursday, October 31, 2013, 8:55pm; Reply: 15
[quote=1034][/quote]

Wow - Lola. Please do that more often!!!!
Posted by: Goldie, Friday, November 1, 2013, 5:59am; Reply: 16
would give a tr
Quoted Text
y to or ABM and also Cprinus comatus...espec. whil in combo with diabetes;) ..  but the very best is... Goldie test yourselve and the pilzli whith what kind of pilzli you're going into resonance... must be honest all do have very similar duties to fulfill with our bodies as agents... but there must bve a special reaction upon the one you're going to need....  perhaps even Chaga might be one of the next options  !!! ...wish you luck and all the best....


Amazone is telling me that I ought to test mushrooms with my finger prick sugar test.. It might help diabetes to a great degree, especially if I would find out which one is good to eat.. maybe Dr D somewhere said that eating one mushroom a day might make all the difference.  liking mushrooms would help greatly.

I am certain that some sups are full of one mushroom or another, I just have not read about it Yet...
Posted by: Lola, Friday, November 1, 2013, 6:46am; Reply: 17
Christopher1
;D
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