2.3 Observations in humans
2.3.1 Studies of tolerance in healthy volunteers
In a study of potential adverse effects, 60 healthy volunteers were given 50 g of trehalose in 400 ml of water after an overnight fast. No abdominal symptoms of diarrhoea were reported (Bolte et al., 1973).
In a study in which 10 volunteers were given a single dose of 25 g of trehalose in 200 ml of water 1 h after breakfast, there was no reported diarrhoea or other abdominal symptoms (Heine et al., 1996).
In an investigation of the laxative dose of trehalose, 20 female students were given a single daily dose of trehalose in 200 ml of solution 2–3 h after a meal. The dose of trehalose was increased gradually from 10 to 20, 30, 40, 50, and 60 g per treatment. The indigestible disaccharide lactulose was used as a positive control. The physical condition and gastrointestinal symptoms of all subjects were recorded before and after treatment. Half of the subjects had no gastrointestinal symptoms, even at the highest dose tested (60 g), whereas lactulose caused diarrhoea in 75% of subjects after ingestion of 40 g. Both trehalose and lactulose caused high prevalences of abdominal symptoms including flatulence, distension, and borborygmus, but the effects of lactulose were significantly more severe than those of trehalose at the same dose. While there was significant variation between individuals, the threshold dose for transitory laxation was estimated to be 0.65 g/kg bw for trehalose and 0.26 g/kg bw for lactulose (Oku & Okazaki, 1998).
In a study of the absorption of trehalose, 30 healthy adults (15 of each sex) were given trehalose at a single oral dose of 10, 20, 30, or 40 g. The concentrations of hydrogen gas in expired air and of glucose in blood were measured before and every 30 min after administration for 3 h. Subjects were considered to be suffering from malabsorption if the hydrogen gas concentration in expired air increased by more than 20 ppm from the standard value. The subjects were also examined for gastrointestinal symptoms (malabsorption, abdominalgia, laxation, abdominal dysphoria, and crepetus). The rates of malabsorption of trehalose were 0%, 40%, 43%, and 75% at 10, 20, 30, and 40 g, respectively, while the rates of gastrointestinal symptoms were 0%, 40%, 43%, and 50%. Malabsorption was found in more than half of the subjects given 40 g of trehalose. While no racial differences in the ability to absorb trehalose were seen between Mongoloid (Japanese), white, and black individuals, the Japanese had a significantly higher incidence of gastrointestinal symptoms (Ushijima et al., 1995).
2.3.2 Studies of trehalase-deficient individuals....
Quoted from SquarePegI'm shaking my head at this. I know that when I start to crave sugar (or sweet things) my body is telling me to get more sleep. The article that Chloe linked to validates this.
Chloe, I don't think Goldie means to eat a pound of Trehalose in a day!
Chloe, it has always been a mystery to me that some people don't think Trehalose is sweet! Maybe it has something to do with it being plain Trehalose which I have not tried yet???
Cloe... Good limonaid ... who said that... Just allowed is good enough ... for me that is.. sweet well that is a matter of how much one stayed away from sugar per se..
One teaspoon or even a table spoon TC will not make it sweet, just sweeter haha that is why I wish to buy plain T so as not take to much TC.. 1 teaspoon per 6 oz might be just right.. or at least explain why you did not taste it... I think I could tast one grain of sugar in a glass... so would my body sugar insulin reaction.. that is why TC was such a good thing.. and T should be guilt free sweet... still need to buy it, and wish to get mushroom kind.. !
Cloe... the pictures unter your link are yummmyyyyyy ! The comparison chart does not seem to account for why I do not care for lemons...
Lime in water.. I love it with the skin left in the water.. makes it even more bitter Yumm.
Oh I use very little... half a lime/// could be grapefruit also... or just carrot juice??
I am not spoiled any more... I am a reductionist... nearly nothing anymore to please my palate... diabetes took all fun out of life/eating and drinking...
I really feel for you, Goldie, having to deal with this multifaceted problem. Does exercise help you keep your sugar down? Are you allowed agave on SWAMI? Or barley malt or maple syrup or vegetable glycerine? You've probably said, but I can't remember off hand. I'm curious to know how Dr. D. addresses diabetes.
Today you might be seen by Dr. Natalie Colicci, Dr Vanessa Doyle, Dr. Maria Zangara, Dr. D'Adamo, or students (if a Shift patient).I was surprised to be sent to someone else in the same office.
So you see, I am going to look into the Swami Pro, and maybe spend the 800 or 1200 it mightl cost, because within its pages may be way more information to lead me on my way.