Print Topic - Archive

BTD Forums  /  Journal Club and Literature Review  /  Gene Signature Predicts Aspirin Resistance
Posted by: Lloyd, Tuesday, July 16, 2013, 2:17pm
http://directorsblog.nih.gov/gene-signature-predicts-aspirin-resistance/#more-1596

Quoted Text
Aspirin reduces the risk of stroke and heart attack by changing the properties of platelets, which are sticky, gelatinous disc-shaped fragments of cells that help repair damaged blood vessels. The correct balance of platelets is important for good health. Too little platelet activity increases the risk of bleeding; too much boosts the risk of blood clots that can cause strokes and heart attacks. Low doses of aspirin make the platelets less sticky and thus less likely to form clots. This has been a mainstay of reducing heart attacks and stroke, particularly in patients who’ve already suffered from one.

There are already tests that can determine whether aspirin reduces platelet stickiness in an individual, but they’re impractical in clinical practice because of their expense and technical difficulty. To find a better way to identify non-responders, the researchers measured the activity of platelets in patients with heart disease and healthy participants who took aspirin, and studied the activity of genes (specifically, by measuring RNA levels for individual genes) in whole blood samples.

The scientists discovered an “aspirin response signature”—an activity profile of 60 genes—that revealed whose platelets didn’t respond to aspirin (that is, their platelets were still sticky). Interestingly, many of the genes that turned up in the signature were expressed in platelets, rather than in other blood cells. The diagnostic signature predicting aspirin resistance was also associated with deaths from stroke or heart attack.
Posted by: Amazone I., Tuesday, July 16, 2013, 5:06pm; Reply: 1
the problem with aspirin, equal of what kind is: in elder persons it might cause gastrointestinal bleedings and no-one seems to remark it!!!

I often look when my older patients.. between 75 and up became paler then normal I'm nearly sure (and such a product is implemented :-/ :P) I'll always give a try to choose supps bloodtype specifique instead... I know whitecoated love me especially while gone ;) ... but I don't see any good if those elderlies have to suffer coz those aren't aware of nearly nothing.... :o(scared)(mad)(shrug) and often I was right in acting likeweise coz always I ordered to check feritin ... it was low ;)...so far so well ;)...

btw. interactions between chemical bombs are often the culprit for heart attacs and strokes as well ... :-/ coz all chemical bombes eat up nutritional values in vits, minerals and so on and have thes known sideefects.... :-/
Posted by: cindyt, Wednesday, July 17, 2013, 4:39am; Reply: 2
Quoted from Amazone I.
the problem with aspirin, equal of what kind is: in elder persons it might cause gastrointestinal bleedings and no-one seems to remark it!!!



Daily aspirin has also been found to significantly increase the incidence of wet macular degeneration, in susceptible older people.
Posted by: Henriette Bsec, Wednesday, July 17, 2013, 10:07am; Reply: 3
I am allergic to aspirin- get severe swelling of throat and nasal areas
When I had my daughter with a CS - the hospital forgot and I had so much trouble breathing
- problem is that I am severe allergic to morphine as well :o
Good that my pain limits are very high so I just used paracetamol a few days .
Posted by: Goldie, Wednesday, July 17, 2013, 11:00am; Reply: 4
Quoted Text
Daily aspirin has also been found to significantly increase the incidence of wet macular degeneration, in susceptible older people.


any details?  Mom Had it andf I am O so no aspirin for me..

Yet I took thousands of Excedrins and Bufferins before BTD and took thousands of Tylenol ... three decades worth and as many as I needed...  then I found a cure for my pain..  

But still I have diabetes.. and one in the fam sees double.. has bear paws in her eyes, ..
Posted by: Patty H, Wednesday, July 17, 2013, 10:45pm; Reply: 5
I would certainly be interested in which genes are associated with success with aspirin.  According to my 23andMe profile, I am at risk of deep vein thrombosis.  Red wine is also good, yes?
Print page generated: Tuesday, September 30, 2014, 12:01pm