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BTD Forums  /  Journal Club and Literature Review  /  Piperine and curcumin
Posted by: Lloyd, Wednesday, May 22, 2013, 5:50pm
http://www.ncbi.nlm.nih.gov/pubmed/9619120

Quoted Text
Abstract

The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2 h post drug. Time to maximum was significantly increased (P < 0.02) while elimination half life and clearance significantly decreased (P < 0.02), and the bioavailability was increased by 154%. On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.


Provides an argument that perhaps we should be using black pepper even if it is otherwise an avoid.
Posted by: Amazone I., Wednesday, May 22, 2013, 8:41pm; Reply: 1
this is well known since years here in CH -land ;) :D... but thanx for the reminder dearest Lloyd  :D(clap)(ok)(smarty)
Posted by: PCUK-Positive, Wednesday, May 22, 2013, 10:46pm; Reply: 2
if you are a rat, perhaps. ;)
Posted by: Lloyd, Wednesday, May 22, 2013, 10:50pm; Reply: 3
Quoted from PCUK-Positive
if you are a rat, perhaps. ;)


On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%.

Seems to work better in humans.  ;) Rats have better bioavailability without the piperine. Whether it is of any import is a separate matter, that it has a clear effect is not a separate matter (based on this study and I have not looked at the study parameters).
Posted by: Spring, Wednesday, May 22, 2013, 11:08pm; Reply: 4
If I ingested very much pepper, I wouldn't know whether I was dying from the effects of whatever else ailed me or the pepper!! :o I have been this way all my life. I used to wonder why I had the stomach ache for three days after eating a small sausage when I was just a child. I never told anyone, though, until I was older. I guess I thought it was normal!  :-/
Posted by: Victoria, Thursday, May 23, 2013, 12:05am; Reply: 5
Quoted from Spring
If I ingested very much pepper, I wouldn't know whether I was dying from the effects of whatever else ailed me or the pepper!! :o I have been this way all my life. I used to wonder why I had the stomach ache for three days after eating a small sausage when I was just a child. I never told anyone, though, until I was older. I guess I thought it was normal!  :-/


Yeah, me too.  Black pepper gives me such pain in my stomach and intestines! :-/
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