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BTD Forums  /  Supp Right For Your Type  /  Folate, folic acid, MTHFR and cancer risk
Posted by: misspudding, Monday, December 31, 2012, 3:44am
My family carries at least one of the MTHFR genes. My sister learned she had one copy of one of the gene variants after having repeated miscarriages. I am pretty sure I must have it, as I have a history of seizures. Other items. Both my sister who had recurrent miscarriage and I get migraines. Mine come with aura, which I've read is consistent with having one of the MTHFR genes. Both of us also have terrible gluten sensitivity, and my son has fructose malabsorption, which I know I have some sensitivity with, as well...

We also have schizophrenia and Asperger's in the family, though on a separate family line.

(Yes, we're Irish-American.)

Anyway, with the MTHFR stuff, I've taken methyl b-12 for a long time, but have been taking regular folic acid. No mega doses, except while I was pregnant due to my seizure history, per my OB/GYN's orders. Now I see that folic acid has risks:

I just saw this:

So...two questions. I don't know if any of you have the answers but I don't know if my standard PCP will know, either. Should I be taking folic acid or should I try to find methylated folate? If so, should I worry about cancer? ??)
Posted by: marjorie, Monday, December 31, 2012, 9:23am; Reply: 1

Wow it sounds like you are dealing with alot of issues. I wish I knew more to help you out but I dont feel educated enough in this area to make a true statement.

Other than, I am glad you have followed BTD, and I am curious about the cancer issue as well.

However, I will post on another thread. Good luck and keep doing what you can do to have control over your life.

Posted by: AKArtlover, Monday, December 31, 2012, 4:24pm; Reply: 2
There is a different form of folate. I will be taking soon, not sure if it is what you are referring to. My folic acid levels were high. I think what my doc was saying is that I could have trouble reducing. The methyl b12 is the correct form, but the folate needs to be different (or the level watched).I tend to take supps as my body feels like it needs them, so I was probably balancing the need for the b12 with doing the work of handling the form of folic acid that comes with. I think I'm switching over to a just b12 supplement when the folate changes over. Have a big list I'm working on. Best money I've ever spent.

I don't eat processed foods, so all the fortification isn't an issue for me anymore. I do remember reading that this was an issue related to this genetic variation.

I think the only way to know is to have your genes tested and talk with a doctor who works with this stuff. There are lots of variations and linked genes with MTHFR from what little I've read on it.

My background includes Ireland, too. Mixed American mutt, though. Cheers.
Posted by: misspudding, Tuesday, January 1, 2013, 3:19am; Reply: 3
Marjorie, it's okay. I haven't had seizures in over a decade, and I only get migraines when I don't get enough magnesium (I tried a paleo diet...I found I really needed the beans and/or brown rice occasionally!).

But yes, I'm concerned with taking the regular folic acid now. I think I must have some ability to convert folic to folate in the body, as my sister seems to have a rougher go with migraines and I didn't have miscarriages, and she only had one copy of the gene. I just worry about cancer and heart disease (a grandfather died at 55 from a massive heart attack...almost certain he was an A, though).

And yes, AKArtlover, I am definitely looking into a practitioner who is more knowledgeable about this stuff. Think it's about time I found a naturopath or integrative medicine type.
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