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BTD Forums  /  Supp Right For Your Type  /  Piperine (BioPerine®) in Nutraceuticals
Posted by: Conor, Sunday, June 24, 2012, 12:00am
I've only found one casual reference to 'piperine' in the archives and eight references to "bioperine," but they were of no relative consequnce to the subject of this thread. Am wondering if anyone else has considered this question and possibly done some research on it ...

Piperine is often included in many supplements today as a phytochemical potentiator, i.e., because of its claimed ability to improve the bioavailability of various nutriceuticals (as measured in several clinical studies). BioPerine® is made from piperine and it seems to be showing up as a supplemental additive in an ever increasing number of products. Usually it's in the 3 mg range in terms of amount per serving. However, piperine, a pungent component in plants of the Piperaceae family (which includes Piper longum and Piper nigrum), appears to be nothing other than a highly-refined extract of black pepper. I believe that the patented BioPerine® form is 95- to 98-percent piperine and 2- to 5-percent proprietary extract of Zingiber officinale (ginger) ... that is, if I read the patents correctly.

The list at this link provides an example of how many nutritional supplements piperium can be included to enhance bioavailability:

In ER4YT, I think black pepper was, at best, a neutral for any blood type. In GT and SWAMI, pretty much all forms of Piper nigrum, i.e., black, white and green, are listed as avoids for me. Does anyone know if Doctor D'Adamo has mentioned whether or not piperine falls into the same category as black pepper? If not, has anyone found a definite answer from an alternate source regarding the supplementary intake of piperine by those for whom black pepper is an avoid?

Thanks in advance for any input.

Addendum: A separate issue is the extraction of piperine; i.e., a common means of commercial extraction is via dichloromethane. As far as I can tell, this compound is considered to be both a carcinogenic hazard by the U.S. Department of Health and Human Services and potentially fetotoxic (New York State Department of Health, Division of Occupational Health and Environmental Epidemiology). Given these concerns, I'm also trying to discern whether or not this solvent (DCM) is used in obtaining food grade piperium and, if so, does it fully dissipate once the piperium extraction process is complete?
Posted by: Spring, Sunday, June 24, 2012, 12:56am; Reply: 1
I haven't seen it in anything that I take, and I certainly hope I don't because black pepper is one of my absolute worst offenders!!!! Cardamom is a deeeeelicious substitute!! It is fantastic in or with eggs!! (smile)
Posted by: Victoria, Sunday, June 24, 2012, 1:15am; Reply: 2
Dr. D doesn't like for people to eat any pre-ground pepper because it is so quick to grow mold.  
Posted by: Lola, Sunday, June 24, 2012, 1:27am; Reply: 3
ask customer service what is used in DPN formulas as phytochemical potentiators......they might be of more help to you, perhaps


Posted by: C_Sharp, Sunday, June 24, 2012, 1:33am; Reply: 4
I have take supplements containing it and have not noticed any adverse effect, but I generally do not react to small amounts of pepper.

It is generally added to increase absorption of other nutrients in the pill.


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There are some studies indicating beneficial effects of Piperine itself. A study that has been getting a lot of press coverage recently indicates that it inhibits the growth of fat cells.

http://www.care2.com/greenliving/how-to-harness-the-healing-power-of-black-pepper.html
Posted by: Conor, Sunday, June 24, 2012, 4:19am; Reply: 5
Quoted from Lola
ask customer service what is used in DPN formulas as phytochemical potentiators......they might be of more help to you, perhaps

(ok) Yep, I'll call them on Monday. Can't find any NAP products with piperine, but I also haven't looked through all of them.
Posted by: Conor, Sunday, June 24, 2012, 4:45am; Reply: 6
Quoted from C_Sharp
I have take supplements containing it and have not noticed any adverse effect, but I generally do not react to small amounts of pepper . . .

I haven't noticed anything adverse from ingesting piperine, either. I've cut out black/white/green pepper per SWAMI's recommendation but, for whatever reason, I've never seemed to have any problem with black pepper. I'd rarely ever salt my eggs or cow brains as a kid, but would always practically blanket them in black pepper and pico de gallo. Anyhow, given that piperine is such a concentrated extract of black pepper, I'm just trying to figure out if its avoid status would be likewise amplified.

Thanks for the study link ... intriguing.
Posted by: Amazone I., Monday, June 25, 2012, 1:55pm; Reply: 7
it's allways mixed with 500mg's of curcuma and I always recommend this to my A'types
for different reasons :D....(whistle)even sometimes B's, AB's of course and O gatherer and explorers... mostly hunters dind't showed any positive reactions while having been tested on the bioresonance system.....I guess it's coz of the bloodthinning-effect.... ??)
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