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BTD Forums  /  The Encyclopedia/ D'Adamo Library  /  Sulfite oxidase deficiency, revisited
Posted by: TJ, Wednesday, July 27, 2011, 2:56am
I've just been doing some reading on sulfite oxidase, particularly on what it looks like.  According to my reading, this is a very rare and usually fatal condition, one that manifests within the first few days of life.  It causes seizures, mental retardation, and developmental delays.

I'm now thinking that neither I nor anyone participating on this forum  has this condition.  If we are sensitive to sulfite, there's probably another reason for it besides an inborn, recessive-trait, metabolic error!  Any ideas on what could be the actual cause?  The only thing I can think of is molybdenum deficiency.
Posted by: TJ, Monday, August 8, 2011, 1:07am; Reply: 1
Bump
Posted by: C_Sharp, Monday, August 8, 2011, 1:26am; Reply: 2
Since many people develop sulfite senstivity later in life when they have not been sensitive to sulfites before I presume is is not always a genetic condition.

Here are some somethings that interfere with sulfite oxidase activity in cells:

* heavy metal molecules such as lead and mercury,
* SO2/SO3-group containing drugs including DMPS
* Sulfa-drugs (e.g. a class of drugs within the sulfa group that can impair pterin synthesis, such as asthmatic inhalants and many antibiotics),
* molybdenum deficiency,
* severe B12-vitamin deficiency
Posted by: C_Sharp, Monday, August 8, 2011, 1:27am; Reply: 3
Testing for sulfite sensitivity:

http://www.medical-library.net/content/view/453/41/
Posted by: TJ, Monday, August 8, 2011, 3:24am; Reply: 4
Quoted from C_Sharp
Here are some somethings that interfere with sulfite oxidase activity in cells:

* heavy metal molecules such as lead and mercury,
* SO2/SO3-group containing drugs including DMPS
* Sulfa-drugs (e.g. a class of drugs within the sulfa group that can impair pterin synthesis, such as asthmatic inhalants and many antibiotics),
* molybdenum deficiency,
* severe B12-vitamin deficiency
Thanks C#, the only one of those I was aware of was molybdenum deficiency.
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