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BTD Forums  /  Journal Club and Literature Review  /  Zonulin's "Identity", Leaky Gut, & Autoimmunity
Posted by: TJ, Monday, February 7, 2011, 5:28pm
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Scientists led by Alessio Fasano, M.D., have identified zonulin as a molecule in the human body called haptoglobin 2 precursor.

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"While apes, monkeys and chimpanzees do not have haptoglobin 2, 80 percent of human beings have it," says Dr. Fasano. "Apes, monkeys and chimpanzees rarely develop autoimmune disorders. Human beings suffer from more than 70 different kinds of such conditions. We believe the presence of this pre-haptoglobin 2 is responsible for this difference between species."

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In celiac patients, gluten generates an exaggerated release of zonulin that makes the gut more permeable to large molecules, including gluten. The permeable gut allows these molecules, such as gluten, access to the rest of the body. This triggers an autoimmune response in which a celiac patient's immune system identifies gluten as an intruder and responds with an attack targeting the intestine instead of the intruder. An inappropriately high level of production of zonulin also seems responsible for the passage through the intestine of intruders other than zonulin, including those related to conditions such as diabetes, multiple sclerosis and even allergies. Recently, other groups have reported elevated production of zonulin affecting the permeability of the blood brain barrier of patients suffering from brain cancer.
Posted by: Lola, Monday, February 7, 2011, 5:46pm; Reply: 1
yup......the gut, our second brain ;)
Posted by: Harry O, Monday, February 7, 2011, 8:09pm; Reply: 2
Interesting article and so thanks TJ !! Like lola always says ''heal the gut, heal the body''  ;D
Posted by: Amazone I., Monday, February 7, 2011, 8:20pm; Reply: 3
:o perhaps might be it more true to call our gut * our 2cond feelings* :B wisdom ::)
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