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BTD Forums  /  Nonnie Clubhouse  /  Non-secretors and vitamin B12 levels
Posted by: Vista, Saturday, October 31, 2009, 6:41pm
Hello, I wonder if anyone knows if this means that the measured levels of vitamin B12 in blood plasma generally is higher for non-secretors than secretors?

Are secretors more suspectible to not absorb vitamin B12 and folate and to get deficiency? It seems like it is a common problem for women to have B12 and folate deficiency.
Posted by: Lola, Saturday, October 31, 2009, 8:05pm; Reply: 1
Dr D has considered all these issues when designing the individualized guidelines....

I believe our choice of foliate and supplementation are well taken into consideration for optimal balance.
Posted by: Vista, Saturday, October 31, 2009, 8:09pm; Reply: 2
Hi Lola, but is it non-secretors or secretors that can be most suspectible to have B12 and folate deficiency?
Posted by: Andrea AWsec, Saturday, October 31, 2009, 8:21pm; Reply: 3
Posted by: Lola, Saturday, October 31, 2009, 8:24pm; Reply: 4
probably so
Posted by: Andrea AWsec, Saturday, October 31, 2009, 8:29pm; Reply: 5
SIBO= Small Intestinal Bowel Overgrowth ( measured with a breathe hydrogen test)

Quoted Text
Vitamin B12 deficiency occurs in SIBO as a result of
utilization of the vitamin by bacteria. When bacteria take
up the vitamin, it is partially metabolized to inactive analogues,
which compete with normal vitamin B12 binding
and absorption (31,32). Folate levels, however, are usually
normal or elevated in the context of SIBO because
bacteria are able to synthesize folate (33).

Once again it comes back to digestive health. So take care of your gut and it will care for you.
Posted by: Vista, Saturday, October 31, 2009, 8:31pm; Reply: 6
Hello Andrea AWsec, I have recently read something about non-secretors, genotype associated with norovirus resistance yields higher B12.  

I guess both non-secretors and secretors can get B12 deficiency but maybe secretors are more suspectible?
Posted by: Andrea AWsec, Saturday, October 31, 2009, 8:38pm; Reply: 7
Your link does not work.

Non secretor A's are particularly at risk due to low levels of stomach acid, but that is not the whole story, intestinal bacteria plays a role as I mentioned above.
Things are not always as simple as they seem.
Posted by: Andrea AWsec, Saturday, October 31, 2009, 8:49pm; Reply: 8
Quoted Text
Absorption of B12 requires the secretion of the glycoprotein intrinsic factor (IF) from the gastric cells, binding of IF to vitamin B12 and a functional gastrointestinal absorption system2. The H-antigen synthesized by FUT2, Lewis ABO antigens, and FUT2 genotypes have all been reported to mediate H. pylori attachment to human gastric mucosa10. Atrophic gastritis is a consequence of H. pylori infection11 and leads to reduced secretion of IF12,14. The FUT2 secretor status has been associated with both H. pylori infection and gastritis10; patients with vitamin B12 malabsorption and low levels of serum vitamin B12 have higher seroprevalence of H. pylori infection10. These data suggest a potential mechanism by which vitamin B12 absorption1215 may be reduced in carriers of the secretor genotype due to the sequelae of susceptibility to H. pylori infection compared to individuals with the nonsecretor genotype.

Non secretors have more H.Pylori. They need to get rid of the H.Pylori and heal the gut, this will maximize the B12 absorption. Healthy gut + healthy bacteria =helps B12 get absorbed.
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