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BTD Forums  /  Live Right 4 Your Type  /  This question is a bit technical, but here it goes
Posted by: Eric, Wednesday, June 17, 2009, 4:39am
I need some help understanding the paradox between MAO and stress in O's.

1. O's have naturally lower levels of Monoamine Oxidase platelet enzymes
2. MAO breaks down catecholamines like adrenaline and noradrenaline
3. When O's exercise, MAO increases, which breaks down the catecholamines-- and thus causes the de-stressing factor
but
4. MAO also breaks down dopamine, which is a monoamine.  
so
How do O's have a net increase in dopamine (the make-you-feel-good neurotransmitter) from exercise, even though increased MAO means decreased dopamine?
Posted by: Lola, Wednesday, June 17, 2009, 6:49am; Reply: 1
here s a few quotes which might help answer your question
Quoted Text
why type O's are not recommended to use St Johns Wort. Aside from the fact that the two cases of "photo sensitization"
Type O's have lower levels of the enzyme MAO, and St. Johns
Wort is an MAO inhibitor feel "weird" or have disturbing dreams
type O's with mild to moderate depression do benefit from the
amino acid tyrosine (which can boost dopamine levels), and arginine (which is used to recycle nitrous oxide in the nervous system). Also, the gene for the enzyme dopamine beta hydroxylase sits right on top of the ABO gene and there are indications that this may cause psychiatric syndromes to be somewhat related to ABO blood group. Maybe those Japanese personality observations were not so off-the-wall after all?


Quoted Text


Quoted Text
stress. Many type A's with poor sleeping and stress tolerance are cortisol imbalanced. Why not try some St. John's Wort? It is a mild MAO inhibitor (probably) but actually more significantly, helps modulate cortisol metabolism through the p-450 enzyme system of the liver.


Quoted Text
"The blood type O gene is very tightly linked to the gene for Dopamine Beta Hydroxylase" meaning that Os don't produce enough ornithine decarboxylase.  The shortage of this enzyme has digestive and emotional consequences, which results in Os having difficulty clearing some stress hormones and neurotransmitters out of their system. It does this by inhibiting the production of mono amine oxidase, which is responsible for clearing these things out (this being the reason why Os don't respond to MAO antidepressants)  It is also the reason Os are more prone to bipolar and unipolar depression.  We release enough neurotransmitters, but have no built-in ways of clearing them out.
Blood Type O has lower levels of the enzyme MAO, and St. John's wort is an MAO inhibitor. This may explain why many Type O's on St. John's wort say they feel "weird" or have disturbing dreams.  I have found, however, that blood Type O's with mild to moderate
depression benefit from the amino acid tyrosine, which can boost dopamine levels, or the Russian adaptogenic herb rhodiola, which
helps modulate adrenaline and dopamine levels in the brain.


Quoted Text
cravings (under "stress and emotional stability"): "Many type Os crave either wheat or red meat. Wheat is one of the highest plant sources and red meat one of the highest animal sources of L-tyrosine, the building block of dopamine and the catecholamines." type O responds to stress with higher levels of catecholamines (adrenaline molecules) than the other blood types, and they do not clear them out of their bloodstream as fast. This is probably related to a gene linked to ABO that is involved in the regulation of dopamine metabolism, (the elective shunting of
tyrosine to dopamine or adrenaline or thyroxine). We also know that even normal healthy type O's have lower resting levels of platelet MAO (monoaminoxidase)which is known to produce a variety of personality manifestations including 'monotony avoidance.'
Posted by: Eric, Wednesday, June 17, 2009, 7:12am; Reply: 2
Thanks Lola!  Those are great articles, but still don't really quench my perplexity :/
Posted by: Amazone I., Wednesday, June 17, 2009, 9:09am; Reply: 3
I think it's about the serotonin/dopamine question when dopamin is released people get alert; even a bit stressy ;) :D...but when serotonin is released, people get calm and friendly and happy.... ;D

agonist=antagonist!!!
Posted by: CB, Wednesday, June 17, 2009, 2:36pm; Reply: 4
Lola, in response to your quoted text (yes, this is your twin, except for blood type which is A):  I am an Ao and love to run, but everytime I read the stuff about As and exercise, it throws me.   Running makes me feel great!!  I only run 5 to 6 miles/hr and also do weight bearing because it makes me feel great too.   Having said that I don't want to take years from life.   This is my quandry.    Where is Dr. D when I need him?    Take care.  CB
Posted by: Eric, Wednesday, June 17, 2009, 5:11pm; Reply: 5
CB, I have A friends who also say they get a big de-stress from running.  Maybe it's like BTD->GTD... special genes are probably involved with that?

Isa, that makes a lot of sense!  B/c after running, I definitely feel relaxed, and not nearly as alert... but it's still a good feeling.  So exercise does decrease dopamine, but instead increases serotonin....  
Posted by: Amazone I., Wednesday, June 17, 2009, 5:20pm; Reply: 6
;)(smarty)(clap) you got me schweety ;) :K) (li. O-of mine 1/3 or perhaps only 1/8 %centage??) ;) :K) ;D :D...)

btw..CB... I don't get you right now; are you an A1 vor an A2....??) I think if you are an A2 there might be a little o to be found.. or better said we are prone to go for more oks for intake of fatty acids, for example... :D(smarty)...what I always tested negative for the A1-types.... :o(dissappointed)(hand)(smarty2)(naughty)(goofy)(whistle)
Posted by: proto, Wednesday, June 17, 2009, 5:27pm; Reply: 7
Nothing wrong with running. You just have to watch your pulse and take it easy if it gets out of the range. As for range there must be a calculator somewhere buried on this site.
Quoted Text
RESOURCE: Calculate Your Heart Rate Range

To calculate your desired heart rate during exercise, subtract your age from 220, then use 60 percent and 80 percent of that number as your fitness range. Here's an example, based on a 36-year-old:
SUBTRACT AGE      BOTTOM OF RANGE      TOP OF RANGE
220 - 36 = 184      184 x .6 = 110      184 x .8 = 147

This 36-year-old would aim for a heart rate between 110 and 147 beats per minute for a fitness workout.

There are all kinds of heart rate monitors on the market to help you measure your progress. But they are not the only method for determining your exercise intensity.
Posted by: Lola, Wednesday, June 17, 2009, 8:42pm; Reply: 8
CB,
exercise no matter what type you are, needs to feel right!
so the one you do, making you feel right, is the right one for you!!!
there are no set rules...... ;)
Posted by: Lola, Wednesday, June 17, 2009, 9:15pm; Reply: 9
the mechanisms vary from Bt to BT since the gene for the enzyme
dopamine beta hydroxylase sits right on top of the ABO gene

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Catechol-O is formulated to optimize dopamine metabolism in type O's. It is not really a 'supplement' in the sense that it does some sort of semi-pharmacologic thing. What it does do is supply elements similar to the O diet in slightly higher amounts. I doubt one can become acclimated or addicted to it, since its actions are much like the diet itself.


Quoted Text
5HTP is probably OK in type O's...

Unfortunately, I've given up using it in my own practice as it didn't seem to work all that effectively, certainly not as effective as the older pre-problem L-tryptophane.

In general O's are better off boosting dopamine than they are boosting serotonin. try a little L-tyrosine instead.


Quoted Text
It is only my completely subjective opinion that many grain eating-vegetarian type O's are dopamine deficient, and perhaps
because of this some tend be more introverted, others more angry or agitated.
http://www.dadamo.com/forum/archivea/config.pl?read=71148
Posted by: Eric, Thursday, June 18, 2009, 6:44am; Reply: 10
Great info, Lola!  And nice job on the Espaņol site!!  I just checked that out today :)
Posted by: Lola, Thursday, June 18, 2009, 7:01am; Reply: 11
has your perplexity been quenched yet? ;)
Posted by: italybound, Thursday, June 18, 2009, 4:01pm; Reply: 12
Quoted from CB
...  I am an Ao


okay, I'm always so confused about this blood typing thing.
Can one be Aa, Bb, or is it always Ao, Bo, Oo and AB. I know an A and a B or an O and a B can have an O baby, so this leads me to believe it is always Ao and Bo. Is that right?  :-/
Posted by: 815 (Guest), Thursday, June 18, 2009, 5:40pm; Reply: 13
Quoted from CB
   Running makes me feel great!!  I only run 5 to 6 miles/hr and also do weight bearing because it makes me feel great too.   Having said that I don't want to take years from life.   This is my quandry.    Where is Dr. D when I need him?    Take care.  CB

I used to run also, before my hips went.  I read that animals who have shorter lives than us,  have hearts that beat very fast. When you increase your heart rate you shorten your life. Wasn't man meant to sprint if I'm not correct? Only short distances of fast sprinting to run from predators?  The reason why you feel so great  is because when you run, your body is being stressed and the body compensates for that by releasing endorphins to take the pain away. So in actually, (especially in A's), you are being stressed more than if you swam or walked... by running instead. But I don't know if this applies to O's.. :-/ :)
Posted by: Melissa_J, Friday, June 19, 2009, 6:12am; Reply: 14
Quoted from italybound


okay, I'm always so confused about this blood typing thing.
Can one be Aa, Bb, or is it always Ao, Bo, Oo and AB. I know an A and a B or an O and a B can have an O baby, so this leads me to believe it is always Ao and Bo. Is that right?  :-/


Most As are Ao, and most Bs are Bo (heterozygous), and they can give an O gene to their child (so 2 As can have an O child). But there are some who are AA or BB (homozygous).  You can often tell if you have a recessive O just by the blood types of your parents, siblings, and children.  If one of them is an O, then you would probably have an O gene as well.
Posted by: CB, Friday, June 19, 2009, 7:54pm; Reply: 15
For example, I am an A, my mother was a B, my father was deceased before I became interested in this.   I also know now that my mother has both B and O siblings (since I tested them), so I received the O gene from Mom and there for must have gotten the A from dear old dad.   Take care.   CB
Posted by: CB, Friday, June 19, 2009, 8:07pm; Reply: 16
Quoted from 815

I used to run also, before my hips went.  I read that animals who have shorter lives than us,  have hearts that beat very fast. When you increase your heart rate you shorten your life. Wasn't man meant to sprint if I'm not correct? Only short distances of fast sprinting to run from predators?  The reason why you feel so great  is because when you run, your body is being stressed and the body compensates for that by releasing endorphins to take the pain away. So in actually, (especially in A's), you are being stressed more than if you swam or walked... by running instead. But I don't know if this applies to O's.. :-/ :)


Obviously, I don't know how to do the quotes and would be happy to learn from more savvy ones than I.    Regarding the above statement, smaller animals even people have faster heartbeats, don 't know why, but they do.   Also who gave the talk about exercise, was it Dr. Prof. Uhlenbreck (sp?) at the 2007 conference about the rats.   Two groups of rats were fed the same and everything else the same except one group was exercised.   Then they exposed both groups to stressors and all the non-exercising rats died.  Now this year we learned that different species respond differently regarding blood type, nevertheless I thought it was interesting study.   Take care.   CB

Posted by: Melissa_J, Friday, June 19, 2009, 9:49pm; Reply: 17
Also note that regular exercise will cause your resting heart rate to slow down.  So it's elevated during exercise, but somebody who is in shape will have it return to the resting rate faster after exercise, and will have a lower resting heart rate.   That lower resting heart rate is a big advantage when you or your body are stressed by illness or other outside forces...you can roll with the punches a bit better.

You can monitor how quickly your heart rate returns to normal after exertion to see how much the exercise "stressed" your body.  If you train regularly, but don't overtrain, then you should be able to build up gradually and have your heart rate return to resting fairly quickly...so 5 or 6 miles of running may not be too much if you're consistent and your heart rate returns to normal soon after.  

When you first begin an exercise program, be careful of that, but if it's already part of your routine, then I say go for it.  Just monitor things when you're increasing your intensity.
Posted by: Jenny, Saturday, June 20, 2009, 3:43am; Reply: 18
Quoted from italybound


okay, I'm always so confused about this blood typing thing.
Can one be Aa, Bb, or is it always Ao, Bo, Oo and AB. I know an A and a B or an O and a B can have an O baby, so this leads me to believe it is always Ao and Bo. Is that right?  :-/

there's no need to go on being confused about the blood typing thing, it is incredibly logical. Draw up a few grids with (invented or real)mother across one side, and father across the other. Then fill in the four blanks with all the possible combinations. Its a chance factor about which one meets each other.
My mother was A1 / A2 and the reason I know this is that without elaborate testing of her blood, we discovered that at least one of her children is A1 and at least one is A2.

Posted by: Mrs T O+, Saturday, July 18, 2009, 8:49pm; Reply: 19
Do you think that there will ever be a blood test to find out if someone is AA or BB?
My friend's parents were both As & she is an A. There is a chance she is an AA, but can we find out?  Incidentally, her dad died of cancer in his 40s & the mother is still alive at 90 & was very active, maybe still is. I'd love to know. She is single & no kids to try to figure it out.
I knew that my mom was AO b/c we are Os. I knew my grandma was BO since my mom was A. Now I wouldn't know if my grandpa was AA or AO. That would be nice to know. If they had an O child, I would know..... It's hard to believe that he died almost 50 years ago, Aug. 27, 1959!   Wow! Time flies on an SST or a moon rocket!!
Posted by: Andrea AWsec, Saturday, July 18, 2009, 8:53pm; Reply: 20
Are you trying to check her cancer risk? or is this just a basic question?


What do her fingerprints look like? Does she have whorls?


A friend of my husbands  a man, has beautiful hands with longer d2's and every print is a  whorl all ten fingers, tons of cancer in his whole family..
Posted by: C_Sharp, Saturday, July 18, 2009, 9:28pm; Reply: 21
Quoted from Mrs T O+
Do you think that there will ever be a blood test to find out if someone is AA or BB?


As long as one is willing to pay for it, DNA testing can be used to distinguish between the AA and Ao genotypes or the BB and Bo genotypes.


If you do not to spend money on DNA testing one can take all the information one has and work out the probability of a particular genotype.


Or if one lacks enough information on relatives one can use genotype percentages for a general population in published studies.

For instance a Japanese study found for phenotype A group, AA =19.8 % and Ao = 80.2%; and for the phenotype B group, BB =12.8% and Bo=87.2%.


Posted by: Dr. D, Sunday, July 19, 2009, 3:06pm; Reply: 22
Quoted Text
How do O's have a net increase in dopamine (the make-you-feel-good neurotransmitter) from exercise, even though increased MAO means decreased dopamine?


Exercise blocks dopamine beta hydroxylase.
Posted by: wwbailey, Sunday, July 19, 2009, 3:34pm; Reply: 23
I know one thing.  I've been exercising all my life and besides Meat and fish oil, it's the biggest thing that has made me feel stable and balanced in my brain chemisty and emotions.

I don't need any further scientific proof or explanations!  :)
Posted by: Memento Mori, Monday, August 10, 2009, 1:32am; Reply: 24
This is the Blood Type Punnet table:

                  Dad's BT:

                               o     o
Mom's BT:     A      Ao    Ao

                        o      oo    oo

So if they have four children then chances are two of them will be BT O and two will be BT A. There are other factors that can interfere on occasion but this is the basic numbers on it.
Posted by: C_Sharp, Monday, August 10, 2009, 1:51am; Reply: 25
Do we know that Mom's genotype is: Ao  ?
Some people with a blood type of A have a genotype  of AA.

If one parent is AA and the other is oo,
all children will be blood type A   (With a genotype of Ao)
   o   o
A  Ao  Ao
A  Ao  Ao
Posted by: Eric, Monday, August 10, 2009, 6:23am; Reply: 26
Quoted from Dr. D
Exercise blocks dopamine beta hydroxylase.


Beauty!  Thanks

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