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BTD Forums  /  Nonnie Clubhouse  /  Metformin,. read up on side effects of neuropathy
Posted by: Goldie, Monday, February 11, 2013, 7:15am
I just read up on Glucophage or Metformin and read that it may cause Vit B 12 uptake shortages which can cause nerve damage over a 12 year time frame at which time it is to late to reverse it.

I am one person who has said that diabetes is not the originator of nerve pain but that neuropathy is on early sign of diabetes.. NOW I 'see' the relationship about what I 'supposed' all along, but now it seems that my first signs might have been B12 issues in 40. - 50.

Then they talked about pernicious anemia, which I seemed to be able to avoid.  Now it may well have been my first diagnosis of ONSET of diabetes.

Nerve damage is a slow oncoming cause of much pain later in life.   Pay attention and talk to your doctors about it.  Even weeks or month without symptoms or cramping still does not mean that the nerve damage is not progressing ever so slowly.

I am glad I looked up side effects on computer, I will discuss my nerve issues with my doctor and make sure I understand more about my B12 levels.  They have fluctuated and because of my meat eating are good enough for normal people but maybe not for me as Gatherer with diabetes.  I will be much more vigilant.

(I also will see a practitioner that uses a test 'hand' which will be able to evaluate other issues like missing minerals and the like.)      
Posted by: NewHampshireGirl, Monday, February 11, 2013, 3:30pm; Reply: 1
Extremely interesting!  Thanks, Goldie.
Posted by: ruthiegirl, Monday, February 11, 2013, 5:13pm; Reply: 2
People take drugs like metformin to keep their  blood sugar under control and PREVENT complications such as neuropathy! And how simple it would be to put b12 in the pills with the drug.
Posted by: Possum, Monday, February 11, 2013, 9:27pm; Reply: 3
Thanks Goldie!! Was just talking about MotherinLaw this morning & how she has neuropathy but she is in complete denial about diabetes (despite the fact that her own father developed mature onset D??!!)
Didn't quite realise it could be an early sign... So she could have it & it not show up in tests? Which would mean, what with that fact & her denial, it would put her off having further tests?
She & FinL are both O's & eat very little protein (some chicken/tuna but especially very little red meat) They mostly eat carbs &/or packet soups etc (filled with cheap thickeners)
Posted by: ApplesCarrotsnGrain, Tuesday, February 12, 2013, 6:40am; Reply: 4
Interesting. I didn't know. Has anyone heard about metformin being linked in studies to stopping cancer growth?
Posted by: Goldie, Tuesday, February 12, 2013, 1:07pm; Reply: 5
well depending on their ages, diabetes is a nasty disease to ADMIT to.. It took me years and sis still does not know.. 10 years later..

so you see, the reason we do not wish to have the genetic illness, is because there is such stigma attached.  AND the diets prescribed by the diabetes powers to be, they advise on doing  fruit first, or two slices of bread.. and then vegetables nd sometimes meat..

In my book that is exactly wrong all the way.. Yet people and specifically doctors listen to that.. no wonder  people have a hard time..

Having said that you can see why I say it is not their fault.. it is hard to accept and even harder to know what to do..
Posted by: Dr. D, Tuesday, February 12, 2013, 1:25pm; Reply: 6
Any herb that contains berberine works in a manner akin to metoformin: By blocking MTOR via enhancing the activity of AMPK.
Posted by: Goldie, Wednesday, February 13, 2013, 12:54am; Reply: 7
Thanks Dr D.. but (my limited searches is information way more than I can figure out.  I will talk to DR about concerns.. )

Berberine:  A naturally occurring chemical compound, berberine is found in the roots and stems of several plants, in­cluding Hydrastis canadensis (gold­enseal), Coptis chinensis (coptis or goldthread) and Berberis aquifoli­um (Oregon grape). Long used as a remedy in Chinese and Ayurvedic medicines, berberine is known for its antimicrobial properties and as a treatment for bacterial and fungal in­fections. Several decades ago, ber­berine was used to treat diarrhea in patients in China. That was when doctors noticed that the blood sugar levels of diabetes patients were low­er after taking the herbal extract—and berberine began to be investigated for this purpose.

mTor:   Abstract
Diabetes mellitus currently affects more than 170 million individuals worldwide and is expected to afflict another 200 million individuals in the next 30 years. Complications of diabetes as a result of oxidant stress affect multiple systems throughout the body, but involvement of the cardiovascular system may be one of the most severe in light of the impact upon cardiac and vascular function that can result in rapid morbidity and mortality for individuals. Given these concerns, the signaling pathways of the mammalian target of rapamycin (mTOR) offer exciting prospects for the development of novel therapies for the cardiovascular complications of diabetes. In the cardiovascular and metabolic systems, mTOR and its multi-protein complexes of TORC1 and TORC2 regulate insulin release and signaling, endothelial cell survival and growth, cardiomyocyte proliferation, resistance to β-cell injury, and cell longevity. Yet, mTOR can, at times, alter insulin signaling and lead to insulin resistance in the cardiovascular system during diabetes mellitus. It is therefore vital to understand the complex relationship mTOR and its downstream pathways hold during metabolic disease in order to develop novel strategies for the complications of diabetes mellitus in the cardiovascular system.

On interesting word to search out more..confusing as to benefits or be counter to..:

"The possibility of increased diabetes risk needs to be taken into account."

AMPK:    Regulation by adipocytokines

Adipokines, also known as adipocytokines, are secreted by adipose tissue to take on several different but important physiological roles in the body including the regulation of appetite, metabolism, fatty acid catabolism, coagulation and systemic inflammation, for example. Collectively, the adipokines are in essence cytokines (cell-to-cell signaling proteins) which, when secreted, act on other cells, usually resulting in a biochemical and metabolic response. Two particular adipokines, adiponectin and leptin, have even been demonstrated to regulate AMPK.

Information way more than I can figure out.  I will talk to DR about concerns..
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