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General consensus on 23andme? *
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Brimstone
Sunday, January 8, 2017, 11:42am Report to Moderator Report to Moderator

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Before the forum closes I was just wondering what the general consensus was on the 23andme?
I've only just come across it and haven't been tested as yet but think it's something I would like to know in the near future when funds allow...but, I shall most likely have it done when this forum in sadly no more...
...so, just want to glean as much info from your great minds before that day comes...
So, how has it made a difference to your lives and what information would be good for me to know.
Just dipping my tiny toe in, but it all sounds pretty complicated to the uninitiated...that's me...at the mo.
Am also looking for someone to tell me about it in plain English as I'm a bit overwhelmed with all the terminology and jargon.
Hope some of you will be happy to guide me.
Thank you.
Also, sorry if I have posted this in the wrong place...

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C_Sharp  -  Saturday, January 14, 2017, 10:21pm
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Lola
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you have one of the experts close-by

contact Tom Greenfield for targeted advice and follow-through


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C_Sharp
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I do not know what you want the 23 & Me data for.

If it is not for something specific like Opus 23 & Me, then you need to to do the test that is going to provide the desired information in the desired format.

If you do not have a specific use for the information then you may want to save your money.

If you want/enjoy working with genetic info, then you may want to consider more complete testing available from companies using more recent procedures.

For instance Genos Research test the whole exome instead of selected SNPs (which is what 23 & Me does).

https://genos.co/order.html




MIfHI                            I follow a SWAMI diet.
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C_Sharp
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Quoted from Brimstone

So, how has it made a difference to your lives and what information would be good for me to know.


Endless entertainment value. No end of data to look at.  Analyzing the vast pile of information from 23 & Me could keep fully occupied for this lifetime and the next.

Have gotten no practical or useful information from 23 & Me test results (tested 6 years ago).



MIfHI                            I follow a SWAMI diet.
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Mrs T O+
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I found some useful info lIke what nationalities I might be. Some of that is guessing. I found out I had a big chunk of Italian which is cool. The Greek was mixed in with Balkan. So even tho those countries seem different than Greece to me, apparently the DNA ( or whatever genetic material there is) is similar. There was a smattering of other nearby countries' genetic results, but no real surprises. Someone else may find they are part something they had no idea of.
Then it gave info of what diseases I might be prone to. The 2 major ones are not in my family at all, but it was interesting to know. It also gave chances of Alzheimer's. Since that had become more common, it it nice to know. For somebody, that might be more than worth the price of the test!

I don't have a powerful computer to read all the details, but I got the major things.
There were several groupings of letters that are supposed to mean something thst I don't understand, like A-B+  For various classifications, like Diego blood group.....  A professional could read those.
Still, for my 99 bucks, I got a good amount of info. I really wanted to know the nationalities I am and this was helpful. The only danger is that even tho your info is confidential, there is no guarantee someone could get a hold of it in later years to blackmail or try to control people.


Interested in nutrition, lactation, religion, politics; love to be around people; talkative, sensitive, goofy; fishy Christian ><>; left-handed; lived on a farm, small town & big city; love BTD/GTD;  La Leche League veteran; b. 10/1947 Check BTD/GTD on facebook!
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Brimstone
Monday, January 9, 2017, 7:03am Report to Moderator Report to Moderator

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Recently I was diagnosed with thyroid disease.
My mum then had to get tested and her antibodies are raised but other thyroid test results are ok which means she will have to be tested regularly.
Anyway, the reason I asked about the genetic testing is that my mum was an abandoned baby and we have no clue to the family line on her side, I just thought that even with having no family history we could find out possibly if there was any genetic info that could be useful.
Which is why when it turned out I had thyroid disease she had to be tested...funny that it wasn't the other way round...
Anyway thanks for all your replies, I think it's something that I may look into further...I think it will help with my detectoring.
Thank you 🙂
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Dr. D
Monday, January 9, 2017, 9:41am Report to Moderator Report to Moderator

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Averno
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Quoted Text
Opus23 is a suite of apps that provide a development environment for generative precision medicine.
It allows the clinician to import raw genomic data (such as provided by 23andMe and other services)


Is Genos one of the "others" that can be imported into Opus23?

If so, does Genos provide a more accurate or detailed Opus23 report?

Does Genos provide ancestry data (to the extent that 23 and Me does)?
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Mrs T O+
Tuesday, January 10, 2017, 2:19am Report to Moderator Report to Moderator

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Brimstone, I think it would be great if your mum could get tested. I would be very curious to know my ancestry and disease possibilities.
I think a lot of folks have thyroid problems because we don't have enough iodine and have too much fluoride and chloride in our environment. There are a coupe of other "ides" that affect the iodine. Filters can get rid of chlorine, but you need a more expensive one to get rid e fluoride we are forced to have in our tap water.


Interested in nutrition, lactation, religion, politics; love to be around people; talkative, sensitive, goofy; fishy Christian ><>; left-handed; lived on a farm, small town & big city; love BTD/GTD;  La Leche League veteran; b. 10/1947 Check BTD/GTD on facebook!
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Brimstone
Tuesday, January 10, 2017, 6:21am Report to Moderator Report to Moderator

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Thanks Dr D for posting the link, am glad I'd have to go through a pro with this one...
...blimey Charlie...looks crazy and amazing all at the same time...
...the fantasmatron sounds particularly intriguing!
I guess I need to get clued up a little and give DrThom a ring.

Hey Mrs T, I think you're right about the iodine and the fluoride...have been reading about this lately and have bought some lugols iodine but haven't started it yet...also am having fluoride free toothpaste although I'm not entirely sure if fluoride is added to our water here or not...will check.
Anyway yes it's scary how many people are being effected by thyroid disease and the numbers keep rising by all accounts.
I don't think Mum will go for the opus but I'm very interested to find out my genetics.
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Lola
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Quoted Text
Does Genos provide ancestry data (to the extent that 23 and Me does)?


I believe Dr D is focusing on 23&me data results to input into Opus23 , not genos


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
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C_Sharp
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Quoted from Lola


I believe Dr D is focusing on 23&me data results to input into Opus23 , not genos


That is correct.  But unless the intention is to get Opus 23, than there appears to be little reason to use use the old 23 & Me approach of testing selected SNPs versus testing the whole exome which is offered by other vendors.



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cajun
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Just my 2 cents....
I am glad I did 23andme to find a first (once removed) cousin in Canada...one I had never met.
Her dad is my first cousin...his dad and my dad are brothers.
Amazing that we shared DNA on nearly every chromosome!!!!!
Like MrsT, I found ethnicities I hadn't known about! I knew some Italian and French/Spanish Basque
but had no clue about the small percentage of Finnish and the larger amount of Balkan!
Also,
They update my health reports constantly as new research is done. Carrier status is informative!
Thank goodness I am not a carrier for any of the very serious, dreaded diseases...some rare.
Apparently, my parents passed on only the best of themselves to me.


 Ao  ISFJ   Taster   Rh+  

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Averno
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Thank you Lola and C_Sharp  
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RedLilac
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My son, 1st Cousin & myself did it years ago right before they stopped the health analysis.   I found out interesting information.  I connected with distant cousins.  I uploaded my data to other sites.  I'm glad I did it.


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Dr. D
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There is no problem with Genos data, other than the sheer size. However, except for isolated instances, more is generally only more. This is due to the knowledge gap between what can be discovered and what is known. Reporting a new SNP is not difficult; it simply requires some patience and the necessary technology. Being able to draw some sort of meaningful conclusion from the SNP is a much, much bigger deal. Now you have to do the epidemiological work, which is   involved, complicated and expensive. For example, 23andme reports about 700,000 snps. Of these, we know 'something' about around 7,000, while we are able to draw actionable conclusions on closer to 3000 - 4000.

Of the rest? Black hole.  Granted, though,  there are some cool SNPs not reported by 23andme, or buried in the 'i' (internal ids) numbers versus the conventional 'rs' id number.



A whole system is a living system is a learning system.’ -Stewart Brand
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hunter23
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I'm a new member here, but I read the Genotype diet years ago and discovered I was a Hunter. I joined here because my 23andMe data matched up almost identically with D'adamo's Hunter profile. Prone to adrenal fatigue? Not only do I have constant anxiety, but my data says I have a couple genetic markers that make adrenaline more readily available in my body than most. Celiac/gluten intolerance? I haven't tested positive (if I remember correctly), but I have a rare gene that makes me 3x as likely to have celiac.

Long story short (yes, genetic data can be a llooonnngg story), you can spend $99 on the ancestry report, get your raw data, and take it over to a free site like codegen.

Combining what I've learned from that, with the suggestions in Genotype Diet, I feel pretty confident in my ability to take control and balance everything through nutrition and exercise.
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BHealthy
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I had my mother's genome decoded several years ago, when she was diagnosed with Dementia, to see if she had the Alzheimer's gene.  She doesn't, which is proof that it doesn't really 'predict' anything (so why on earth is it called the Alzheimer's gene.

BUT,  I also looked at her MTHFR and CBS SNPs, because she had migraines, allergies, asthma, HBP, shingles, and a host of other maladies that might have been MTHFR related.  I discovered that she is homozygous for many of those SNPs which means that I am at least heterogygous.  

Knowing that I may not be able to process B12 or sulfur helps me manage my diet and my supplements.  Someday (soon - I have the kit, just haven't sent in the sample), I will have my genome decoded and analyzed by Opus23, so I'll know for sure which SNPs I need to address.

My BFF, who has suffered from a host of ailments for many years, had her genome decoded last year and discovered that she has a SNP that makes her body unable to recognize mold as a toxin.  She contacted Opus23 to see if they could help her but I don't think mold is one of their specialties.  If it is, please LMK which practitioner she should see.  

These are just two reasons why you might want to have your genome decoded - the information could help you avoid and/or treat health issues.  Here's a better explanation of the reason why you might want to be tested: http://suzycohen.com/articles/snpsmethylation/ and here's a link to how Opus23 can help you http://northamericanpharmacal.com/living/2016/01/mthfr-methylation-and-you/

One downside to having it done is that it might uncover health problems for which there is no cure, and many people prefer not to know what they'll die from.

    


"Excellence is the result of caring more than others think is wise, risking more than others think is safe, dreaming more than others think is practical, and expecting more than others think is possible."

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C_Sharp
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Quoted from BHealthy
I had my mother's genome decoded several years ago, when she was diagnosed with Dementia, to see if she had the Alzheimer's gene.  She doesn't, which is proof that it doesn't really 'predict' anything (so why on earth is it called the Alzheimer's gene.
    


Alzheimer's is not caused by a single gene.

Many genes influence ones likelihood to develop Alzheimer's.

Environment plays a role it is not simply genetics.

I am presuming what you are calling the "Alzheimer's gene" is the APOE gene.  This gene only affects one type of Alzheimer's --early onset.  Risk for other type of Alzheimer's appear to be unaffected. Alzheimer's is only one type of dementia.  Now if we want to specifically focus on early onset alzheimer's. There are several variants of APOE. Some are protective some increase the risk of developing early onset Alzheimer's.  Note that I said increased risk to develop early onset Alzheimer's.  Having an APOE4 variant does not mean that you will develop early onset Alzheimer's environment still plays a role.  Likewise having APOE2 or APOE3 variants does not mean that you will not develop early onset Alzheimer's. It is just that the risk is a little lower.

I do not know who you had do the genetic testing.  But if it was an inexpensive testing firm like 23 & Me.  The testing methodology probably only looked at a few specific SNPs on the APOE gene and ignores most of the gene.  So there could be mutation for other areas of the APOE gene that was missed because the testing was incomplete.

APOE does not encode an Alzheimer trait it encodes the making of Apolipoprotein E.  Abnormal forms of Apolipoprotein E affect cholesterol metabolism.  Change to cholesterol metabolism not only shift risk (up and down) of early onset Alzheimer's but also for cardiovascular problems.


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Brimstone
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This is just one of the many good examples of why we will lose so much when the forum goes...

Thanks for letting me know Hunter23, sounds like you have gleaned a lot of really useful information through the 23andme to help you with your healthcare.

Thanks BHealthy for posting the links although the link to the Opus info didn't work on my device, I have found some good info on Opus.
The Suzy Cohen link was really interesting and nice and easy for me to understand which is exactly what I was after...now reading more about 23andme and Opus I don't feel so utterly clueless...all those letters and numbers in no particular order or pattern can really confuse a girl just starting to dip her toe in the massive gene pool...

C_Sharp could you recommend a genome decoding company for me if you think the 23andme is too simplistic or incomplete and does this mean that 23andme is not quite good enough?

Thank you folks.
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C_Sharp
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Quoted from Brimstone

C_Sharp could you recommend a genome decoding company for me if you think the 23andme is too simplistic or incomplete and does this mean that 23andme is not quite good enough?



There are variety of companies and prices for gene testing services.

Those paying $20,000 can obviously get better testing and more complete results.

One needs to decide what one is going to use the information for to know whether more complete data is worth paying for.

If you want complete exome testing at a low price.  You might consider Genos Research.

https://genos.co/

They are only $500.

They are fairly new, so their reliability is unknown.

Even for $500, you need to weigh whether the extra data is worth it to you.



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KimonoKat
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I want to get 23 & me testing for my husband and myself. I want to get it to eventually have Opus 23 run on my husband.

My question is, what "more" does the $199.00 test give you that the $99.00 test does not.

Dr. D recently answered my question about whether the $99.00 had the SNP data attached. He said it does. So, it would seem to me that the $99.00 test would be enough for the end result of eventual Opus 23 testing.

For those of you who have purchased the $199.00 test, what else do you get for your extra $100.00?

Thank in advance.


Knowledge is power.  SWAMI gives you the diet that will unlock the key to better health, and it's all based on your unique individuality.
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Lola
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I am sure COE has the right answers.... all other here might speculate


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ESTJ
The harder you are on yourself, the easier life will be on you!
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C_Sharp
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Quoted from KimonoKat
I want to get 23 & me testing for my husband and myself. I want to get it to eventually have Opus 23 run on my husband.

My question is, what "more" does the $199.00 test give you that the $99.00 test does not.


For those of you who have purchased the $199.00 test, what else do you get for your extra $100.00?


The $99 version is enough for Opus 23.

The additional $100 gives you more health reports.

I do not like the 23 & Me health reports, so I would not spend a $100 for them, but you may be curious about how 23 & Me interprets your health data.

The health reports were better before 23 & Me's run in with government.  So having seen the reports reduced to a tiny subset of what they used to tell you, makes them feel all the more disappointing.


I prefer promethease's interpretation of my 23 & Me data. It is only $5 and tells me more than the $100 reports from 23 & Me.  

https://promethease.com/


MIfHI                            I follow a SWAMI diet.

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KimonoKat
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Kyosha Nim
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Thank you C_Sharp. I suspected the health reports were not all that great.


Knowledge is power.  SWAMI gives you the diet that will unlock the key to better health, and it's all based on your unique individuality.
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