Welcome, Guest.
Please login or register


Main Forum Page  ♦   Latest Posts  ♦   Member Center  ♦   Search  ♦   Archives   ♦   Help   ♦   Log In/Out   ♦   Admins
Forum Login
Login Name: Create a new account
Password:     Forgot password

BTD Forums    The Library    Journal Club and Literature Review  ›  Environmental epigenetics:
Users Browsing Forum
No Members and 2 Guests

Environmental epigenetics:  This thread currently has 592 views. Print Print Thread
1 Pages 1 Recommend Thread
Lloyd
Tuesday, July 30, 2013, 4:24pm Report to Moderator Report to Moderator

GT1 (Hunter)
Sa Bon Nim
Administrator
Posts: 7,226
From reading material for an epigenetics course.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432200/

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships
Victoria K. Cortessis,1 Duncan C. Thomas,corresponding author2 A. Joan Levine,1 Carrie V. Breton,3 Thomas M. Mack,1 Kimberly D. Siegmund,3 Robert W. Haile,1 and Peter W. Laird4



Quoted Text
Noteworthy experimental results, taken together, indicate that epigenetic processes could plausibly mediate effects of environmental exposures to influence disease susceptibility in mammals, since (1) specific exposures induced measurable changes in epigenetic state, (2) new epigenetic state was shown to persist after cessation of exposure, and (3) measureable phenotype was associated with exposure-related changes in epigenetic state. A fourth element, exposure-induced alteration of epigenetic marks of germ cell lineage DNA, seems necessary for transgenerational transmission of environmentally induced epigenetic changes. On this background, we interpret observational human data illustrating associations of exposures to epigenetic state and epigenetic state to disease to indicate that epigenetic mechanisms may plausibly mediate exposure effects on a wide range of human diseases.

Perhaps the greatest significance of this line of research is the potential for designing novel interventions articulated by Dolinoy and Jirtle (200:

    unlike genetic mutations, epigenetic profiles are potentially reversible. Therefore, epigenetic approaches for prevention and treatment, such as nutritional supplementation and/or pharmaceutical therapies may be developed to counteract negative epigenomic profiles.

As an example, Huang et al. (2012) have developed a therapy for reactivating the Ube3a allele that is epigenetically silenced in Angelman syndrome. However, before we begin to realize this translational potential, much research along parallel tracks needs to be conducted.

We need to better understand basic epigenetic mechanisms that operate during selected periods when the epigenome may be particularly vulnerable to environmental exposures (e.g., prenatal and early postnatal periods, childhood, puberty) as well as mechanisms that routinely maintain proper epigenetic states. We also need to understand mechanisms relevant to cumulative effects of exposure and associations with aging, since duration of exposure and aging are co-linear. A better understanding of basic mechanisms at different time points in life would guide genetic epidemiology studies in selecting environmental exposures that are more likely to affect epigenetic processes, identify the most relevant periods of exposure, identify biomarkers of exposure, and suggest biological intermediates to study.

It may be helpful to more deliberately deconstruct the steps whereby an environmental exposure may affect risk of disease via epigenetic mechanisms. For example, studies of the association of environmental exposures with selected epigenetic events as endpoints (rather than intermediates in a complex pathway) may be fruitful and will likely help us better conceive of studies to elucidate an entire pathway, from an exposure acting at least in part through epigenetic mechanisms to disease risk.

As we proceed, it will be important to consider seriously the environmental exposures to study, since we will want to select the most promising candidate exposures (those most likely to affect epigenetic processes), measuring these exposures at relevant time periods and with reasonable accuracy. Also, we cannot ignore genetic influences on epigenetic processes. We see above that studies of the epigenetic state of specific candidate genes are yielding interesting results and more such studies are warranted. Given limited knowledge of this genetic–epigenetic interface, to complement the candidate gene approach, integrative genomics approaches should be contemplated in order to combine GWAS data with epigenomic data. Clearly, statistical and bioinformatics approaches will be required to enable the efficient conduct of these analyses, especially as we expand to genome-wide scale. Similarly, research on feasible, efficient study designs, akin to current research on optimum designs for sequencing-based studies, will be needed. Finally, as with other emerging fields (e.g., the standardization of testing criteria for microsatellite instability or MSI), standardization of terminology and testing protocols will facilitate future communication of hypotheses, scientific approaches, and results.
Logged
Private Message Private message
Lola
Wednesday, July 31, 2013, 1:37am Report to Moderator Report to Moderator

GT1; L (a-b-); (se); PROP-T; NN
Sa Bon Nim
Admin & Columnist
Posts: 51,062
Gender: Female
Location: ''eternal spring'' Cuernavaca - Mex.
Age: 57
swami rules!


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ISTJ
The harder you are on yourself, the easier life will be on you!
Logged
Private Message Private message YIM YIM Reply: 1 - 8
Amazone I.
Wednesday, July 31, 2013, 8:38am Report to Moderator Report to Moderator

Rh+ GT 4...E/..INTJ ....prop.=non-taster..
Kyosha Nim
Columnists and Bloggers
Posts: 16,266
Gender: Female
Location: CH-Benglen Kanton Z�rich
Age: 56
weew thanx for sharing Lloyd I wanted to have this in script form but saw... 1 from  1592 sheets... and then up from sheet 17 american size and swiss size weren't anymore compatible .. woahoa.. ok so far I still will try to read the whole text ! Another thank you for this


MIfHI K-174
Logged
Private Message Private message Reply: 2 - 8
yaeli
Wednesday, July 31, 2013, 9:36am Report to Moderator Report to Moderator

SWAMI Gatherer / Taster / ISFJ
Ee Dan
Posts: 2,547
Gender: Female
Location: Yerushalayim, Israel
Age: 66
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432200/pdf/439_2012_Article_1189.pdf

You may have this printed out on a printer which has a driver with custom scale print option.


Logged Offline
Private Message Private message Reply: 3 - 8
Amazone I.
Wednesday, July 31, 2013, 11:10am Report to Moderator Report to Moderator

Rh+ GT 4...E/..INTJ ....prop.=non-taster..
Kyosha Nim
Columnists and Bloggers
Posts: 16,266
Gender: Female
Location: CH-Benglen Kanton Z�rich
Age: 56


MIfHI K-174
Logged
Private Message Private message Reply: 4 - 8
yaeli
Wednesday, July 31, 2013, 11:37am Report to Moderator Report to Moderator

SWAMI Gatherer / Taster / ISFJ
Ee Dan
Posts: 2,547
Gender: Female
Location: Yerushalayim, Israel
Age: 66


Logged Offline
Private Message Private message Reply: 5 - 8
Spring
Wednesday, July 31, 2013, 5:30pm Report to Moderator Report to Moderator

SWAMI Explorer
Ee Dan
Posts: 3,110
Gender: Female
Location: Southeastern USA
Quoted from Lola
swami rules!


LIKE!


"We are all born ignorant, but one must work hard to remain stupid." -- Benjamin Franklin
Logged
Private Message Private message Reply: 6 - 8
Averno
Wednesday, July 31, 2013, 8:18pm Report to Moderator Report to Moderator

Swami Warrior
Kyosha Nim
Posts: 1,044
Gender: Male
Location: Maryland

Wow!  From fringe to mainstream in the blink of a decade!  
Logged
Private Message Private message Reply: 7 - 8
Goldie
Wednesday, July 31, 2013, 11:11pm Report to Moderator Report to Moderator

All Gatherer -70 Scorp/Sag on BTD/GENO 17 year
Sam Dan
Posts: 5,857
Gender: Female
Location: East Coast
Quoted Text
We also need to understand mechanisms relevant to cumulative effects of exposure and associations with aging, since duration of exposure and aging are co-linear.


Ok this I understood clearly /// the rest.... Interpret for those who are less versed... someone have mercy...

But indeed interesting... I would take my own experience with diabetes as an example... my father developed diabetes at some time in his life... sorry I have no idea when, my Brother di at maybe 40 plus.. I had the gen showing before anyone even thought of genes age 19 but did not develop it until way late in my 50ties.  The differences where lifestyle in the three of us...

It makes me wonder what a study of all who come here would look like... just in terms of money spent on doctors befoe BTD or a year after adhering to its core principals, and a measure or self reported pain scale, wellbeing scale from 1 to 10... !

The potentiality of THE (great) differences might be staggering.


Being here is invaluable, but not enough. We need ALL the Doctors. I needed them for a very small cancer spot-I could never feel!!! Please do your mammograms! Doing so saved me from cancer later on. I am grateful! Thanks for learning from my experience! I was lucky! I wish the same for YOU!
Logged Offline
Private Message Private message Reply: 8 - 8
1 Pages 1 Recommend Thread
Print Print Thread

BTD Forums    The Library    Journal Club and Literature Review  ›  Environmental epigenetics:

Thread Rating
There is currently no rating for this thread