link between inflammation and glycosylation: http://www.ncbi.nlm.nih.gov/pubmed/23150665?dopt=Citation
Peter D'Adamo Now this is interesting. This seems to be linking inflammation with changes in sialylation/desialylation of o-linked mucins. If you've
been to IFHI or read the GM textbook this should peak your interest: the T and Tn pancarcinoma family of blood group antigens are two premiere O-linked
glycans, which like very much to play with EGF (herceptin target). Now, it gets even more interesting. Changes to T and Tn are linked to the progression of
many inflammatory conditions (UC for example). We also know that in general the more inflammatory the breast cancer the more aggressive. Thus we have two
mechanisms behind breast cancer prognosis that link to O mucin aberrant glycosylation: infiltration and inflammation. Broad beans, mushrooms, amaranth and
escargot tend to induce redifferentiation of Tn and T; peanuts tend to encourage it.