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BTD Forums    Diet and Nutrition    Supp Right For Your Type  ›  Folate, folic acid, MTHFR and cancer risk
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Folate, folic acid, MTHFR and cancer risk  This thread currently has 1,167 views. Print Print Thread
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misspudding
Monday, December 31, 2012, 3:44am Report to Moderator Report to Moderator

Rh-, MTHFR, GT4 Explorer
Ee Dan
Posts: 609
Gender: Female
Location: Seattle
Age: 37
My family carries at least one of the MTHFR genes. My sister learned she had one copy of one of the gene variants after having repeated miscarriages. I am pretty sure I must have it, as I have a history of seizures. Other items. Both my sister who had recurrent miscarriage and I get migraines. Mine come with aura, which I've read is consistent with having one of the MTHFR genes. Both of us also have terrible gluten sensitivity, and my son has fructose malabsorption, which I know I have some sensitivity with, as well...

We also have schizophrenia and Asperger's in the family, though on a separate family line.

(Yes, we're Irish-American.)

Anyway, with the MTHFR stuff, I've taken methyl b-12 for a long time, but have been taking regular folic acid. No mega doses, except while I was pregnant due to my seizure history, per my OB/GYN's orders. Now I see that folic acid has risks:

I just saw this: http://www.msnbc.msn.com/id/35.....cancer/#.UOECsOTLSSo

So...two questions. I don't know if any of you have the answers but I don't know if my standard PCP will know, either. Should I be taking folic acid or should I try to find methylated folate? If so, should I worry about cancer?




misspudding

---
Me: Celiac type gut problems; seizure disorder; MTHFR
DH: O positive
DS: O negative; "atypical" IBD - SWAMI 44% Explorer



My health/weight loss blog: http://onehundredfiftyeight.wordpress.com/
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marjorie
Monday, December 31, 2012, 9:23am Report to Moderator Report to Moderator

Hunter/Aquarious/Counselor
Ee Dan
Posts: 1,628
Gender: Female
Location: Colorado
Age: 39
Hi

Wow it sounds like you are dealing with alot of issues. I wish I knew more to help you out but I dont feel educated enough in this area to make a true statement.

Other than, I am glad you have followed BTD, and I am curious about the cancer issue as well.

However, I will post on another thread. Good luck and keep doing what you can do to have control over your life.

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AKArtlover
Monday, December 31, 2012, 4:24pm Report to Moderator Report to Moderator

centered leaning INTP Explorer, Supertaster, SWAMI
Kyosha Nim
Posts: 2,121
Gender: Female
Location: Midwest, US of A
Age: 38
There is a different form of folate. I will be taking soon, not sure if it is what you are referring to. My folic acid levels were high. I think what my doc was saying is that I could have trouble reducing. The methyl b12 is the correct form, but the folate needs to be different (or the level watched).I tend to take supps as my body feels like it needs them, so I was probably balancing the need for the b12 with doing the work of handling the form of folic acid that comes with. I think I'm switching over to a just b12 supplement when the folate changes over. Have a big list I'm working on. Best money I've ever spent.

I don't eat processed foods, so all the fortification isn't an issue for me anymore. I do remember reading that this was an issue related to this genetic variation.

I think the only way to know is to have your genes tested and talk with a doctor who works with this stuff. There are lots of variations and linked genes with MTHFR from what little I've read on it. http://www.functionalmedicine.org/practitioner_search.aspx?id=117

My background includes Ireland, too. Mixed American mutt, though. Cheers.


"For you created my inmost being; you knit me together in my mother's womb. I praise you because I am fearfully and wonderfully made; your works are wonderful, I know that full well." Psalm 139:13,14
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misspudding
Tuesday, January 1, 2013, 3:19am Report to Moderator Report to Moderator

Rh-, MTHFR, GT4 Explorer
Ee Dan
Posts: 609
Gender: Female
Location: Seattle
Age: 37
Marjorie, it's okay. I haven't had seizures in over a decade, and I only get migraines when I don't get enough magnesium (I tried a paleo diet...I found I really needed the beans and/or brown rice occasionally!).

But yes, I'm concerned with taking the regular folic acid now. I think I must have some ability to convert folic to folate in the body, as my sister seems to have a rougher go with migraines and I didn't have miscarriages, and she only had one copy of the gene. I just worry about cancer and heart disease (a grandfather died at 55 from a massive heart attack...almost certain he was an A, though).

And yes, AKArtlover, I am definitely looking into a practitioner who is more knowledgeable about this stuff. Think it's about time I found a naturopath or integrative medicine type.




misspudding

---
Me: Celiac type gut problems; seizure disorder; MTHFR
DH: O positive
DS: O negative; "atypical" IBD - SWAMI 44% Explorer



My health/weight loss blog: http://onehundredfiftyeight.wordpress.com/
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