Quoted from Amazone I.

ahem yesss as usual that doctorle is a bit very late in his arguments

NAC is one of the best to treat overdoses from paracetamol intakes.... and it prevents also rainal failures.... it's simply a joke to put such statements after all

Quoted from Amazone I.

hey youzz wht is your true intention here

Quoted from Peppermint Twist

Holy hysteria, bat peeps!  I don't know what to think now after reading the link in the original post.

Quoted from http://articles.mercola.com/si.....oads-of-trouble.aspx

Since I don’t frequently use supplements, I consulted one of my friends, Dr. William LaValley from Austin, Texas, who is an expert in this area and has reviewed the literature thoroughly.  He successfully uses supplements as a therapeutic tool in many chronic conditions including cancer.

He felt that PAH may be species specific and possibly won’t happen in humans, and more importantly, the study used much higher doses than are generally used in humans.  As mentioned, there are many studies supporting the anti-oxidant benefit of NAC for pulmonary function in cystic fibrosis, post-radiation, and other high oxidant conditions. His conclusion, and I agree, is that a little is probably ok - even good for you. He has used NAC liberally in his therapeutic protocols for nearly 20 years and has not observed any problems with it. However using large quantities is probably not good for you.  Long-term high doses are probably not so good for several reasons - including the possibility of PAH.  

The study says that the doses are higher than usual in humans - but we know that the supplement manufacturers have been making 500mg NAC caps and selling them by the truckload for years. My biggest concern is the use of NAC by cancer patients who think it is helping - when in fact it may be harmful to them by protecting cancer cells and counteracting what potential benefit they may get from some conventional treatments.  It's a thorny issue.

So, if used therapeutically, it should be used in low doses for 'prevention.'  High doses should be restricted to disease/stress states that have high likelihood of high reactive oxygen species generation (such as trauma, certain types of infection, malnutrition, and certain types of toxicity).

Dr. LaValley feels that 200-500mg once a day is probably ok in most non-cancer cases. NAC is an important consideration for inclusion, at some reasonable dose, in anti-aging formulas.