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My Natural Path sent me the following info. and wants to try me out on this Curcumin (tumeric)... any thoughts or comments??? _________________________________________________
Free Radic Biol Med. 2006 Apr 1;40(7):1152-60.
Iron chelation in the biological activity of curcumin.
Jiao Y, Wilkinson J 4th, Christine Pietsch E, Buss JL, Wang W, Planalp R, Torti FM, Torti SV. Department of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. Curcumin is among the more successful chemopreventive compounds investigated in recent years, and is currently in human trials to prevent cancer. The mechanism of action of curcumin is complex and likely multifactorial. We have made the unexpected observation that curcumin strikingly modulates proteins of iron metabolism in cells and in tissues, suggesting that curcumin has properties of an iron chelator. Curcumin increased mRNA levels of ferritin and GSTalpha in cultured liver cells. Unexpectedly, however, although levels of GSTalpha protein increased in parallel with mRNA levels in response to curcumin, levels of ferritin protein declined. Since iron chelators repress ferritin translation, we considered that curcumin may act as an iron chelator. To test this hypothesis, we measured the effect of curcumin on transferrin receptor 1, a protein stabilized under conditions of iron limitation, as well as the ability of curcumin to activate iron regulatory proteins (IRPs). Both transferrin receptor 1 and activated IRP, indicators of iron depletion, increased in response to curcumin. Consistent with the hypothesis that curcumin acts as an iron chelator, mice that were fed diets supplemented with curcumin exhibited a decline in levels of ferritin protein in the liver. These results suggest that iron chelation may be an additional mode of action of curcumin. PMID: 16545682 [PubMed - indexed for MEDLINE]
''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98 DNA mt/Haplo H; Y-chrom/J2(M172);ESTJ The harder you are on yourself, the easier life will be on you!
I didn't read all the links, so this may have been suggested there . . . but your question is about too much iron getting stored in your body? My ND said the easiest way to reduce it is to donate blood regularly.
I am currently having (blood draws)- plbotomy's (spelling by the red cross who desperately needs iron loaded blood weekly for 4 - 6 weeks to reduce the iron buildup. As soon as my ferritin levels are back down to normal range, I will be tested every 3 or 4 months and give if I need to reduce my iron. But in the meantime, I'm going to get on the tumeric and see if it helps! Thanks all!!!