My Natural Path sent me the following info. and wants to try me out on this Curcumin (tumeric)... any thoughts or comments???
Free Radic Biol Med. 2006 Apr 1;40(7):1152-60.
Iron chelation in the biological activity of curcumin.
Wilkinson J 4th,
Christine Pietsch E,
Department of Cancer Biology, Wake Forest University
Health Sciences, Winston-Salem, NC 27157, USA.
Curcumin is among the more successful chemopreventive
compounds investigated in recent years, and is
currently in human trials to prevent cancer. The
mechanism of action of curcumin is complex and likely
multifactorial. We have made the unexpected
observation that curcumin strikingly modulates
proteins of iron metabolism in cells and in tissues,
suggesting that curcumin has properties of an iron
chelator. Curcumin increased mRNA levels of ferritin
and GSTalpha in cultured liver cells. Unexpectedly,
however, although levels of GSTalpha protein increased
in parallel with mRNA levels in response to curcumin,
levels of ferritin protein declined. Since iron
chelators repress ferritin translation, we considered
that curcumin may act as an iron chelator. To test
this hypothesis, we measured the effect of curcumin on
transferrin receptor 1, a protein stabilized under
conditions of iron limitation, as well as the ability
of curcumin to activate iron regulatory proteins
(IRPs). Both transferrin receptor 1 and activated IRP,
indicators of iron depletion, increased in response to
curcumin. Consistent with the hypothesis that curcumin
acts as an iron chelator, mice that were fed diets
supplemented with curcumin exhibited a decline in
levels of ferritin protein in the liver. These results
suggest that iron chelation may be an additional mode
of action of curcumin.
PMID: 16545682 [PubMed - indexed for MEDLINE]