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BTD Forums    Diet and Nutrition    Supp Right For Your Type  ›  A Possible Iron Overload reducer...
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A Possible Iron Overload reducer...  This thread currently has 390 views. Print Print Thread
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funkymuse
Monday, March 5, 2007, 3:02am Report to Moderator Report to Moderator
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My Natural Path sent me the following info. and wants to try me out on this Curcumin (tumeric)... any thoughts or comments???
_________________________________________________

Free Radic Biol Med. 2006 Apr 1;40(7):1152-60.

Iron chelation in the biological activity of curcumin.

Jiao Y,
Wilkinson J 4th,
Christine Pietsch E,
Buss JL,
Wang W,
Planalp R,
Torti FM,
Torti SV.
Department of Cancer Biology, Wake Forest University
Health Sciences, Winston-Salem, NC 27157, USA.
Curcumin is among the more successful chemopreventive
compounds investigated in recent years, and is
currently in human trials to prevent cancer. The
mechanism of action of curcumin is complex and likely
multifactorial. We have made the unexpected
observation that curcumin strikingly modulates
proteins of iron metabolism in cells and in tissues,
suggesting that curcumin has properties of an iron
chelator. Curcumin increased mRNA levels of ferritin
and GSTalpha in cultured liver cells. Unexpectedly,
however, although levels of GSTalpha protein increased
in parallel with mRNA levels in response to curcumin,
levels of ferritin protein declined. Since iron
chelators repress ferritin translation, we considered
that curcumin may act as an iron chelator. To test
this hypothesis, we measured the effect of curcumin on
transferrin receptor 1, a protein stabilized under
conditions of iron limitation, as well as the ability
of curcumin to activate iron regulatory proteins
(IRPs). Both transferrin receptor 1 and activated IRP,
indicators of iron depletion, increased in response to
curcumin. Consistent with the hypothesis that curcumin
acts as an iron chelator, mice that were fed diets
supplemented with curcumin exhibited a decline in
levels of ferritin protein in the liver. These results
suggest that iron chelation may be an additional mode
of action of curcumin.
PMID: 16545682 [PubMed - indexed for MEDLINE]
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Lola
Monday, March 5, 2007, 4:53am Report to Moderator Report to Moderator

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ISA-MANUELA
Monday, March 5, 2007, 8:04am Report to Moderator Report to Moderator
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but isn't curcuma also used as a natural bloodthinner and thus for an O

perhaps you might get an eye into this too..  http://www.orthomed.org   those are the canadian orthomolecular's with fine results and reports

or if that won't work, please go for http://www.vitamincfoundation.org here are also awesome
reports to find good luck

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ISA-MANUELA  -  Monday, March 5, 2007, 8:58am
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funkymuse
Monday, March 5, 2007, 3:19pm Report to Moderator Report to Moderator
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Well curcumin is tumeric and I looked it up on the lists and it's beneficial in a big way for O's.  So it certainly won't hurt for me to take it.
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apositive
Monday, March 5, 2007, 9:27pm Report to Moderator Report to Moderator

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I didn't read all the links, so this may have been suggested there . . . but your question is about too much iron getting stored in your body?  My ND said the easiest way to reduce it is to donate blood regularly.


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Alia Vo
Tuesday, March 6, 2007, 1:52am Report to Moderator Report to Moderator

Kyosha Nim
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Instead of taking a specialized supplement, perhaps you may just want to purchase some organic tumeric powder or purchase fresh tumeric in the produce department.

It is a great medicinal spice; I utilize it daily in my lunch meal.

Alia



Alia A. Vo
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Minneapolis, Minnesota
BTD Lifestyle Since 1999
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funkymuse
Tuesday, March 6, 2007, 3:28am Report to Moderator Report to Moderator
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I am currently having (blood draws)- plbotomy's (spelling by the red cross who desperately needs iron loaded blood weekly for 4 - 6 weeks to reduce the iron buildup.  As soon as my ferritin levels are back down to normal range, I will be tested every 3 or 4 months and give if I need to reduce my iron.  But in the meantime, I'm going to get on the tumeric and see if it helps!  Thanks all!!!
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