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BTD Forums    The Library    Journal Club and Literature Review  ›  Piperine and curcumin
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Piperine and curcumin
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Lloyd
Wednesday, May 22, 2013, 5:50pm Report to Moderator Report to Moderator

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Sa Bon Nim
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http://www.ncbi.nlm.nih.gov/pubmed/9619120

Quoted Text
Abstract

The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2 h post drug. Time to maximum was significantly increased (P < 0.02) while elimination half life and clearance significantly decreased (P < 0.02), and the bioavailability was increased by 154%. On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.


Provides an argument that perhaps we should be using black pepper even if it is otherwise an avoid.
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Amazone I.
Wednesday, May 22, 2013, 8:41pm Report to Moderator Report to Moderator

Rh+ GT 4...E/..INTJ ....prop.=non-taster..
Kyosha Nim
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this is well known since years here in CH -land ... but thanx for the reminder dearest Lloyd  


MIfHI K-174
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PCUK-Positive
Wednesday, May 22, 2013, 10:46pm Report to Moderator Report to Moderator

Kyosha Nim
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if you are a rat, perhaps.


FIfHI

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Lloyd
Wednesday, May 22, 2013, 10:50pm Report to Moderator Report to Moderator

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Sa Bon Nim
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Quoted from PCUK-Positive
if you are a rat, perhaps.


On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%.

Seems to work better in humans.   Rats have better bioavailability without the piperine. Whether it is of any import is a separate matter, that it has a clear effect is not a separate matter (based on this study and I have not looked at the study parameters).
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Spring
Wednesday, May 22, 2013, 11:08pm Report to Moderator Report to Moderator

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If I ingested very much pepper, I wouldn't know whether I was dying from the effects of whatever else ailed me or the pepper!! I have been this way all my life. I used to wonder why I had the stomach ache for three days after eating a small sausage when I was just a child. I never told anyone, though, until I was older. I guess I thought it was normal!  


"We are all born ignorant, but one must work hard to remain stupid." -- Benjamin Franklin
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Victoria
Thursday, May 23, 2013, 12:05am Report to Moderator Report to Moderator

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Sun Beh Nim
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Quoted from Spring
If I ingested very much pepper, I wouldn't know whether I was dying from the effects of whatever else ailed me or the pepper!! I have been this way all my life. I used to wonder why I had the stomach ache for three days after eating a small sausage when I was just a child. I never told anyone, though, until I was older. I guess I thought it was normal!  


Yeah, me too.  Black pepper gives me such pain in my stomach and intestines!



Normal day, let me be aware of the treasure you are.
Let me not pass you by in quest
of some rare and perfect tomorrow.
~Mary Jean Irion
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