Dr. D made this statement on the thread 'Leakey Gut' a real symptom or a vague label ? *:

Quoted from Dr. D

The term [Leaky Gut Syndrome] is more of a depiction than a diagnosis. Permeability can result when certain processes are enhanced (150+ different mechanisms of endocytosis) much more commonly than via some lack of membrane integrity, although the latter can result from infection, drugs or even being a non-secretor.

http://www.drpeterjdadamo.com/wiki/wiki.pl/Endocytosis

I read the link on endocytosis, and I think I have a fair idea of what that means.  My question is this: How are "leaky gut" symptoms caused by the enhancement of these endocytosis processes?

Quoted Text

It [endocytosis] is used by all cells of the body because most substances important to them are polar and consist of big molecules, and thus cannot pass through the hydrophobic plasma membrane.

I think (key word being "think") that it's because the intestines can then absorb molecules that are "too large".  Leaky gut is usually considered to occur when things that shouldn't cross the intestinal lumen or things that are too large cross the intestinal lumen.  If endocytosis is enhanced, that could occur

The term leaky sort of emplies a passive action.  Think of endocytosis as being active leaking, rather than passive.  like i said, though, I'm just guessing

the damage done, cause this permeability

Quoted from brinyskysail

I think (key word being "think") that it's because the intestines can then absorb molecules that are "too large".  Leaky gut is usually considered to occur when things that shouldn't cross the intestinal lumen or things that are too large cross the intestinal lumen.  If endocytosis is enhanced, that could occur

I understand this idea of the "too big" molecules getting out into circulation, and I totally agree!  Big proteins can look like invaders to the immune system, or they may just interfere with metabolic processes by virtue of their shape or other chemical properties.

So what I'm wondering is, if these cells lining the gut gobble up large molecules, how does that get them into circulation?  Do they just spit them back out on the other side, then maybe the next cell in does the same, like a bucket brigade, until that big molecule gets dumped into the blood stream?

I think so...it doesn't take long for it to get into the blood stream.

One theory I've read is that when the body doesn't have adequate nutrition, or doesn't absorb nutrients well, it will purposefully bring in larger molecules.  I'm not sure I'm explaining that very elegantly, but it's a vicious cycle with the inflammatory process when combined with malnutrition.

I'll have to find that link and post it...

The word "malnutrition" takes on whole spectrums of meaning when you consider Dr. D' Adamo's definition of nutrition; no agglutination (anywhere), serum flocculation, polyamine increase, indican increase, etc.

Thank you TJ......

So, I looked up all the words (I) did not understand... then it become quite clear..

Lets say I eat 2 Aspirin (I am O ) :.. the chemical reaction throughout my body is intended to a stop pain - wherever - in all my body parts.. so : in some way the chemical interaction is affecting (ALL) cells in my body.

If I take Vit E : I am creating such a chemical condition that thins my blood also throughout my whole body.  

If I eat avoid foods.. I create a 'chemical environment' that in a short time activates the accumulation of enough extra and intra cellular fluids (by cellular contamination) to cause me to have swollen hands, feet and big belly, and brain.

The only way to get rid of that condition is : Step 1:  Eat Right 4 Your Type..

Thus the term 'leaky gut' is centered in the 'messaging system' located in the Small Intestines which recognizes my SELF contamination (by eating avoids) and then : Step 2 : is sending messages to every cell to protect itself from harm (like lectins) by accumulating extracellular fluids which in turn causes intra-celluar fluids to malfunction..  thus the leak is to my cells through out my body..   as is seen by weight acummulation and edema...

If I understood this correctly, then it is indeed only due to Dr D's diet suggestion that I am not totally distroyed with eating grains, dairy and white foods in general.. Thank you Dr. D.. and your English teacher!  

Quoted from paul clucas

The word "malnutrition" takes on whole spectrums of meaning when you consider Dr. D' Adamo's definition of nutrition; no agglutination (anywhere), serum flocculation, polyamine increase, indican increase, etc.

My 17.9 BMI is enough for me to call "malnutrition" on myself.

Quoted from TJ

My 17.9 BMI is enough for me to call "malnutrition" on myself.

I don't like BMI because I think it's a bad indicator, but my BMI is only 15.4 and that's UP from 13.4

*FRUSTRATION*

TJ.. if you lived in Europe you would be just fine.. by bro used to be size 5 in (comprobale womans) pants.. slim waist and cute behind.. so never worry..

Size is just not where its at 'here'.. FOOD is, neurishment is, environmental differences within the uptake of food is where it is, and in a year from now if you are chipper, happy, and contented then that is where it's at!!   there is hope.. I know of no other place where you find the same..  

Quoted from Goldie

TJ.. if you lived in Europe you would be just fine.. by bro used to be size 5 in (comprobale womans) pants.. slim waist and cute behind.. so never worry..

Size is just not where its at 'here'.. FOOD is, neurishment is, environmental differences within the uptake of food is where it is, and in a year from now if you are chipper, happy, and contented then that is where it's at!!   there is hope.. I know of no other place where you find the same..  

This is sort of what I was getting at, but I realize now that I was very obtuse about it.  What I was trying to say is that your BMI really isn't that low.  Even when I was perfectly healthy and didn't have any digestive problems my BMI was natually lower than yours is now.  Although you want to make sure you don't keep losing weight, you can spend your time in more constructive ways than worrying about your weight.  I know you're trying to figure out why you can't gain weight, and the why is important, just don't stress out about the result of the why (ie your weight).  Everything in time

Quoted from brinyskysail

...my BMI is only 15.4 and that's UP from 13.4

Quoted from Goldie

TJ.. if you lived in Europe you would be just fine.. by bro used to be size 5 in (comprobale womans) pants.. slim waist and cute behind.. so never worry..

Quoted from brinyskysail

I know you're trying to figure out why you can't gain weight, and the why is important, just don't stress out about the result of the why (ie your weight).  Everything in time

No behind here!  My friends and family worry about how skinny I am, and so do I.  I know that, in the USA, we tend to be way fat, so by comparison I do look very thin.  But I'm also weak.  Low muscle strength, low stamina, low muscle endurance, poor muscle tone.  I'm not athletically slim, with ripped cords of muscle.  I'm pretty soft for a skinny guy, and exercise doesn't help; sometimes it just makes it worse by using up my energy even faster.  Comparisons aside, I need to put on some muscle mass, and that's not going to happen until I can make good use of the food I'm eating.

As it is now, I run around getting things done, staying busy...for a while.  Then I collapse into exhaustion while I recuperate.  (This is how I think my bipolar disorder really works).  When I'm staying busy, my body is eating itself to keep going.

I guess what I should say is that I need to heal my gut and digestion, and then the weight gain will follow.

malnutrition for me is = lack of nearly all needed stuffs which enables body to live a healthy life!!! nada màs..

Quoted from TJ

I guess what I should say is that I need to heal my gut and digestion, and then the weight gain will follow.

You'll get there