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Study: Suppression of Breast Cancer Cell Growth with Grape Juice
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Since phytochemicals such as flavones have been shown to be effective inhibitors of aromatase, it is hypothesized that by inhibiting aromatase/estrogen biosynthesis, fruit juices which contain flavones are chemopreventive agents for breast cancer. We have initially evaluated the hypothesis by determining whether fruit juices repress aromatase activity. Our experiments revealed that among seven fruit juices tested, red seedless grape juice was most effective in inhibiting the activity of human placental aromatase. Preliminary studies with a nude mouse model have also been performed to determine the action of grape juice in vivo. For this model, tumors form within one month after inoculating MCF-7aro cells, aromatase expressing breast cancer cells, into eight-week old female nude mice, and tumor formation can be suppressed by injecting the animals with aromatase inhibitors such as 4-hydroxyandrostenedione. We have found that the average tumor size in mice fed (by gavage) with 0.5 ml of grape juice/day is 30% that of the animals not fed with grape juice.