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grapefruit  This thread currently has 1,875 views. Print Print Thread
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Alek
Thursday, July 19, 2007, 8:42am Report to Moderator Report to Moderator

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Kyosha Nim
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Gender: Female
Location: Samos, Greece

There is no need for panic. I have no intention of stopping grapefruit juice [pink] when in season. That is one of my sources of lycopene.
Everything in moderation is the best.




MIFHI


Man is the measure of all things. Protagoras.
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Henriette Bsec
Thursday, July 19, 2007, 9:52am Report to Moderator Report to Moderator

swamied nomad chameleon receptor worldview
Kyosha Nim
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Quoted from btd_forums

There is no need for panic. I have no intention of stopping grapefruit juice [pink] when in season. That is one of my sources of lycopene.
Everything in moderation is the best.


I agree- I will continue to eat a pink grapefruit once in a while


ENFP -naturalist, visual/spatial and musical/verbal/chatty Dane- Mother to DD Emma age 19,
0 rh- secr ( Hunter or Explorer )
Diamonds, superfoods, Neutral,*black dots, avoids
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italybound
Thursday, July 19, 2007, 12:59pm Report to Moderator Report to Moderator

~Concealed~Carry~Hunter~
Kyosha Nim
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Age: 58
Quoted from Frances_AB
Since starting the BTD just over 5 years ago I've been having one almost every day (they're beneficial for AB) and I feel fine. Maybe if you're doing the BTD they're not a problem? (wistfully)


If they are beneficial for your blood type and you have no other health concerns, it seems it would be no worries. Of course, it will be interesting to see where they fall in GTD!!   Hopefully for you, they will still be beneficial.



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Lola
Thursday, July 19, 2007, 3:37pm Report to Moderator Report to Moderator

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Sa Bon Nim
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grapefruit juice can interfere w/ 25 dif meds:
http://groups.google.com/group.....=en#f5c2537e48a93d14


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ISTJ
The harder you are on yourself, the easier life will be on you!
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Alek
Thursday, July 19, 2007, 3:48pm Report to Moderator Report to Moderator

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Kyosha Nim
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Thank you Lola for the link.

There is one more with details.


http://www.qtdrugs.org/consumers/06-grapefruit-juice.htm




MIFHI


Man is the measure of all things. Protagoras.
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Lola
Thursday, July 19, 2007, 3:52pm Report to Moderator Report to Moderator

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Sa Bon Nim
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great site Branka!
thanks!


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ISTJ
The harder you are on yourself, the easier life will be on you!
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Alek
Thursday, July 19, 2007, 4:05pm Report to Moderator Report to Moderator

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Kyosha Nim
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 , right spelling of my name as well.  




MIFHI


Man is the measure of all things. Protagoras.
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Don
Thursday, July 19, 2007, 4:52pm Report to Moderator Report to Moderator

Rh-, MN
Sam Dan
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If you want even more detailed information here is a site that Dr. Crinnion provided at one of the IfHI Conferences that has a CYTOCHROME P450 DRUG-INTERACTION TABLE: DRUG INTERACTIONS | Cytochrome P450 System


FIFHI; ISTP;
Started BTD 3/2002, with 2 O- secretor teenage sons
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italybound
Thursday, July 19, 2007, 5:43pm Report to Moderator Report to Moderator

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Kyosha Nim
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Quoted from lola
grapefruit juice can interfere w/ 25 dif meds:


I've heard this number as high as 30 or more.    



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Lola
Thursday, July 19, 2007, 5:46pm Report to Moderator Report to Moderator

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Quoted Text
right spelling of my name as well

right!
was kind of liking the C lately, right?

thanks Don for that site given!


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ISTJ
The harder you are on yourself, the easier life will be on you!
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Don
Thursday, July 19, 2007, 5:51pm Report to Moderator Report to Moderator

Rh-, MN
Sam Dan
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From the link I posted above these are the substrates that are impacted by grapefruit juice, which is an inhibitor.
Inhibitors compete with other drugs for a particular enzyme thus affecting the optimal level of metabolism of the substrate drug which in many cases affect the individual's response to that particular medication, e.g. making it ineffective.


3A4,5,7
Macrolide antibiotics:
clarithromycin
erythromycin (not 3A5)
NOT azithromycin
telithromycin

Anti-arrhythmics:
quinidine=>3-OH (not 3A5)

Benzodiazepines:
alprazolam
diazepam=>3OH
midazolam
triazolam

Immune Modulators:
cyclosporine
tacrolimus (FK506)

HIV Antivirals:
indinavir
nelfinavir
ritonavir
saquinavir

Prokinetic:
cisapride

Antihistamines:
astemizole
chlorpheniramine
terfenadine

Calcium Channel Blockers:
amlodipine
diltiazem
felodipine
lercanidipine
nifedipine
nisoldipine
nitrendipine
verapamil

HMG CoA Reductase Inhibitors:
atorvastatin
cerivastatin
lovastatin
NOT pravastatin
simvastatin

Steroid 6beta-OH:
estradiol
hydrocortisone
progesterone
testosterone

Miscellaneous:
alfentanyl
aprepitant
aripiprazole
buspirone
cafergot
caffeine=>TMU
cilostazol
cocaine
codeine- N-demethylation
dapsone
dexamethasone
dextromethorphan
docetaxel
domperidone
eplerenone
fentanyl
finasteride
gleevec
haloperidol
irinotecan
LAAM
lidocaine
methadone
nateglinide
ondansetron
pimozide
propranolol
quetiapine
quinine
risperidone
NOT rosuvastatin
salmeterol
sildenafil
sirolimus
tamoxifen
taxol
terfenadine
trazodone
vincristine
zaleplon
ziprasidone
zolpidem


FIFHI; ISTP;
Started BTD 3/2002, with 2 O- secretor teenage sons
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Lola
Thursday, July 19, 2007, 5:58pm Report to Moderator Report to Moderator

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worth taking into account when doing 'drugs'!
thanks!


''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ISTJ
The harder you are on yourself, the easier life will be on you!
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Carol the Dabbler
Wednesday, August 29, 2007, 5:15pm Report to Moderator Report to Moderator

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Kyosha Nim
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I ran across the news of that grapefruit/cancer study a few days ago, while looking for something else, and am just coming down from the "eek!" stage.

In the first place, a 30% higher risk factor sounds huge, and of course it *is* significant -- but it does NOT mean that an additional 30% of the population will get breast cancer, just that the group who does get it will be 30% larger (which is bad enough, of course).  For example, if one is in a group with a 10% risk factor, the 30% rise would take it up to 10% plus another 30% of that 10%, in other words 13% -- NOT 10% plus 30% (i.e., 40%)!  Even though I have two degrees in mathematics, it took me quite a while to convince my subconscious of this!

One of the articles mentioned (and I believe this was quoting the people who did the study) that it takes estrogen levels around 72 hours to come back down -- implying, I would guess, that it might behoove one to wait at least three days between, preferably more.  So I'm thinking maybe once a week (instead of once a day!).

Also, I wonder whether the Grapefruit Diet impacted this study at all.  As I understand it, the claim is that a person can lose weight by simply eating grapefruit before meals.  So I can imagine that overweight ladies might have constituted an unusually large percentage of those who ate the most grapefruit.  Since being overweight is generally considered a risk factor for breast cancer, this might have skewed the results.  (I did read that they had taken several factors into account, such as use of hormone supplements, but weight was not mentioned.)


Carol

A+ nonnie married to an A+ secretor

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Carol_the_Dabbler  -  Wednesday, August 29, 2007, 5:17pm
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Carol the Dabbler
Wednesday, August 29, 2007, 5:45pm Report to Moderator Report to Moderator

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Kyosha Nim
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And of course they did not take blood type into account at all.  I would dearly love to know whether B's and O's (for whom grapefruit is merely Neutral) were disproportionately represented in that extra 30%.  Does grapefruit's Beneficial status win out over the cancer effect for A's and AB's?

By the way, the study did not include men or pre-menopausal women.  Also, they did not distinguish between grapefruit and its juice (though, based on its apparent effect on drugs, I would guess that the juice would be even worse).


Carol

A+ nonnie married to an A+ secretor
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Curious
Thursday, August 30, 2007, 5:42am Report to Moderator Report to Moderator

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I think we would need much more information about the study. Did they only investigate grapefruit? There might have been something else that increased oestrogen levels (which increases in postmenopausal women anyway because of a drop in progesterone). I can't imagine that a single fruit causes breastcancer - but maybe I am only saying this because I have a grapefruit-tree in my garden and I have eaten almost all of them (only a few left).
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Alek
Thursday, August 30, 2007, 9:23am Report to Moderator Report to Moderator

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Kyosha Nim
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MIFHI


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Carol the Dabbler
Thursday, August 30, 2007, 2:31pm Report to Moderator Report to Moderator

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Kyosha Nim
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Thanks, Alex -- that's the one.  As the article says, even the people who did the study consider it "preliminary," and would like to see other researchers expand on it.

Curious -- apparently grapefruit has long been known to intensify the effects of many drugs, so the researchers are making a very-educated guess that grapefruit may also intensify the effects of estrogen.  I have not heard of any other food having a similar effect on drugs.  But this is NOT to say that grapefruit "causes" breast cancer -- merely that it may increase the odds if a woman is already likely to get the disease.


Carol

A+ nonnie married to an A+ secretor
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Karen74
Thursday, August 30, 2007, 6:45pm Report to Moderator Report to Moderator

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For those who don't want to give up eating grapefruit, but worry about these studies suggesting it elevates estrogen, it might be wise to use the NAP supplement Estraphase.  The main ingredient is Calcium D-glucarate which helps detoxify excess estrogen.
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OSuzanna
Thursday, August 30, 2007, 11:44pm Report to Moderator Report to Moderator

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I'm not giving up my more-than-occasional pink grapefruit for anybody. At the moment, anyhow.


OSuzanna
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FOOD for THOUGHT, Super Beneficial 4 All Blood Types!
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Don
Friday, August 31, 2007, 2:45am Report to Moderator Report to Moderator

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Sam Dan
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Quoted from Carol_the_Dabbler
I have not heard of any other food having a similar effect on drugs.

That chart that I posted the link for shows that star fruit is in the same category as grapefruit juice.

There are also a few foods that are listed in the inducer section.


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Curious
Friday, August 31, 2007, 7:55am Report to Moderator Report to Moderator

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Thanks Alek, for this study. I think it summarises it really well - as a preliminary finding which may or may not turn out to be right. I also think, as some of you pointed out, it shows that food rotation is good - in my case - when the grapefruits from my tree are eaten, I won't buy any grapefruit and wait until next year when my tree has got them again. Curious
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Stormstryk
Saturday, September 1, 2007, 6:29am Report to Moderator Report to Moderator
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Quoted from ISA-MANUELA
ooo...aaah it is to be seen in Amazone.com in Teutonia...will go for a reservation as quick as possible ))

btw...happy that it is written....the little word *may*........ I just love grapefruits, one of my favest fruits..... when I tested it with my Vegatester it was a suppaa beneficial wavies to all grapefruit lovers ....


Pardon my newness.. but what pray tell is a "Vegatester".. sounds vaguely intriguing!  I eat (or used to eat..) quite a lot of "exotic" or unusual fruits and veggies.. many of which are not listed on the charts or lectin lists.. if there is a home test option, I would love to know more!

Bright Blessings,
Stephen

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Lola
Saturday, September 1, 2007, 6:32am Report to Moderator Report to Moderator

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Sa Bon Nim
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''Just follow the book, don't look for magic fixes to get you off the hook. Do the work.'' Dr.D.'98
DNA mt/Haplo H; Y-chrom/J2(M172);ISTJ
The harder you are on yourself, the easier life will be on you!
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Alia Vo
Sunday, September 2, 2007, 1:10am Report to Moderator Report to Moderator

Kyosha Nim
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Thank you for sharing the link with us, Alek.

Alia


Alia A. Vo
A Positive Secretor
Minneapolis, Minnesota
BTD Lifestyle Since 1999
John 17
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