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A database of blood group correlations to common diseases



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Auto-immune disease, General


Description:ABH non-secretors have a higher incidence of auto-immune disease in general. ABH non-secretors appear to have an increase in the prevalence of a variety of autoimmune diseases including ankylosing spondylitis, reactive arthritis, psoriatic arthropathy, Sjogren's syndrome, multiple sclerosis, and Grave's disease. This susceptibility towards autoimmune problems appears to be most pronounced among Lewis (a-b-) phenotypes. Among individuals with spondyloarthropathies, non-secretors are reported to make up 47% of the patient population. In the subgroup of these patients suffering from ankylosing spondylitis, ABH non-secretors account for 49% of patients. Since the control population had a prevalence of non-secretors of 27% (consistent with the expected percent in the general population), it appears that in spondyloarthropathies in general, and ankylosing spondylitis specifically, non-secretors are dramatically over represented. (1,2)
Much of the damage done by autoimmune disease is the result of immune complexes, an insoluble lattice network of antibodies bound to antigens in the bloodstream. Immune complexes are harmful when they accumulate and initiate inflammation. Immune complexes, immune cells, and inflammatory molecules can block blood flow and ultimately destroy organs such as the kidney in people with systemic lupus erythematosus, or the insulin-secreting Islet of Langerhans in the pancreas. One of the major jobs of the complement system is to remove immune complexes. The different types of molecules of the complement system make immune complexes more soluble. Complement molecules prevent formation and reduce the size of immune complexes so they do not accumulate in the wrong places, such as the organs and tissues of the body.
References:1. Shinebaum R. ABO blood group and secretor status in the spondyloarthropathies. FEMS Microbiol Immunol 1989 Jun;1(6-7):389-95

2. Shinebaum R, Blackwell CC, Forster PJ, et al. Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies. Br Med J (Clin Res Ed) 1987 Jan 24;294(6566):208-10

3. Manthorpe R, Staub Nielsen L, et al. Lewis blood type frequency in patients with primary Sjogren's syndrome. A prospective study including analyses for A1A2BO, Secretor, MNSs, P, Duffy, Kell, Lutheran and rhesus blood groups. Scand J Rheumatol 1985;14(2):159-62





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PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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