A database of blood group correlations to common diseases

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Ankylosing spondylitis

Description:ABO non-secretors have a higher incidence of ankylosing spondylitis.

The association between non-secretion and ankylosing spondylitis strengthens the hypothesis that the root cause may be an infection. (1)Certain bacteria are known to precipitate reactive arthritis, and may be connected in the pathogenesis of ankylosing spondylitis as well. Susceptibility to many infectious agents is associated with ABO blood group or secretor state, or both. In one study, the distribution of ABO blood group or secretor status, or both, was determined in 87 patients with ankylosing spondylitis, and 32 with other forms of spondyloarthropathy. The prevalence of non-secretors was significant in the total patient group (47%) and in the subgroup with ankylosing spondylitis (49%) compared with controls (27%). (2)
References:1. FEMS Microbiol Immunol 1989 Jun;1(6-7):389-95 ABO blood group and secretor status in the spondyloarthropathies. Shinebaum, R.

2. Br Med J (Clin Res Ed) 1987 Jan 24;294(6566):208-10 Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies. Shinebaum, R., Blackwell, C.C., Forster, P.J., Hurst, N.P., Weir, D.M., Nuki, G.

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2015-1-27: Current Date 21:20:26 GMT: Current Time

PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.