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PATHBASE


A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Infectious disease, Gonnorhea


Description:The genetically determined inability to secrete the water-soluble glycoprotein form of the ABO blood group antigens into saliva and other body fluids is a recognized risk factor for Neisseria meningococcal disease. ABH non-secretors are consistently over represented among individuals contracting this infection. This over representation is even greater among individuals who are carriers of the infection. (1) Secretory immune capabilities and other factors appear to contribute to the relative protection against colonization by meningococci enjoyed by ABH secretors. ABH non-secretors typically have lower levels of anti-meningococcal salivary IgM, and if to add insult to injury, both the IgA and IgM antibodies produced by ABH secretors are more effective at providing protection against this microorganism. (2)
Historically, penicillin has been used to treat gonorrhea, but in the last decade, four types of antibiotic resistance have emerged. New antibiotics or combinations of drugs must be used to treat these resistant strains.
References:1. Blackwell CC, Weir DM, James VS, et al. Secretor status, smoking and carriage of Neisseria meningitidis. Epidemiol Infect 1990 Apr;104(2):203-9

2. Zorgani AA, Stewart J, Blackwell CC, Elton RA, Weir DM. Inhibitory effect of saliva from secretors and non-secretors on binding of meningococci to epithelial cells. FEMS Immunol Med Microbiol 1994 Aug;9(2):135-42





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2015-5-29: Current Date 8:52:54 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2015.


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