PATHBASE
A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Insulin resistance (syndrome X)


Description:Syndrome X is most common for Type As, followed by Type Bs. Individuals of these blood types often have more problems with elevated fasting blood sugar levels, impaired glucose tolerance, hypertension, and high cholesterol and triglycerides. Although no study exists, to my knowledge, I've observed an inordinately high incidence of Syndrome X in Type Bs of African descent, often leading to adult onset diabetes in this special group.

To add to the problem, high cortisol levels, seen in Type A and Type B, actually produce a very similar carbohydrate and lipid metabolism profile as that found in individuals with Syndrome X. These findings don't leave Type Os and Type ABs entirely off the hook,since certain foods will set a pattern of insulin resistance in motion. In fact, every blood type is vulnerable to Syndrome X, given a regular diet of the wrong foods, a sedentary lifestyle, and lack of exercise.

Non-secretors of all ABO groups are also at higher risk for developing Syndrome X. One reason is that non-secretors are especially prone to form clots more readily, and to have slower bleeding times. Studies show that non-secretors are at a greater risk of developing adult onset diabetes, and may have a greater risk of developing complications from diabetes. There is also data that shows that non-secretors and Lewis negative individuals also have a greater risk of developing heart disease and other cardiovascular problems.

Researchers investigated secretor status as part of the Copenhagen Study, and they found supportive evidence of trends toward metabolic differences in the men studied. Compared to all other men, Lewis negative men had significantly higher systolic blood pressure, higher values of body mass index, total body fat mass, fasting values of serum insulin, serum C-peptide, and plasma glucose. These trends, while consistent for men, were not as strong for women.

As a general rule, many overweight individuals have components of, or the entire cluster of symptoms associated with, Syndrome X. The good news is that weight loss can be the key to normalization of these metabolic defects.

Data suggest that Lewis (a-b-) men exhibit features of the insulin resistance syndrome or syndrome X, including a tendency to prothrombic metabolism and higher levels of BMI, SBP, triglycerides, and fasting levels of serum insulin and plasma glucose. These same relationships are not as strong for women.

A group of metabolic problems comprised of insulin resistance, elevated plasma, lipid regulation problems (elevated triglycerides, increased small low-density lipoproteins, and decreased high-density lipoproteins), high blood pressure, a prothrombic state, and obesity (especially central obesity or a predisposition to gaining weight in the abdomen) combine to form "Metabolic Syndrome X" (MSX). This cluster of metabolic disorders seems to promote the development of diabetes (adult onset type II), arteriosclerosis, and cardiovascular disease. And while insulin resistance might lie at the heart of the problem, all of these metabolic disorders appear to contribute to health problems.

Because of the associations with non-secretor status and both diabetes and heart disease, many different researchers have explored the connection between a metabolic syndrome called "Syndrome X" and Lewis and non-secretor blood types. Just as is the case with diabetes and heart disease, individuals with Lewis (a-b-) phenotype are most predisposed to MSX. It has even been hypothesized that Lewis (a-b-) men and syndrome X share a close genetic relationship on chromosome 19 and that the Lewis (a-b-) phenotype is a genetic marker of the insulin resistance syndrome.

As we will discuss in the next section on clotting, non-secretors and especially Lewis negative individuals, are especially prone to prothrombic metabolism (a tendency to form clots more readily and to have slower bleeding times). The tendency to higher triglycerides was mentioned when we discussed heart disease.

Researchers have also investigated Lewis blood types as part of the Copenhagen Study, and they found very supportive evidence of trends toward metabolic differences. Compared to all other men, the Le (a-b-) men had a significantly higher systolic blood pressure (6 mm Hg, P = .0024). They also had higher values of body mass index (8%, P = .016), total body fat mass (25%, P = .015), fasting values of serum insulin (32%, P = .006), serum C-peptide (20%, P = .029), and plasma glucose (8%, P = .003). These trends, while consistent for men, were not as strong for women. (26)
References:1. Petit JM, Morvan Y, Viviani V, Vaillant G, Matejka G, Rohmer JF, Guignier F, Verges B, Brun JM. Related Articles Insulin resistance syndrome and Lewis phenotype in healthy men and women. Horm Metab Res. 1997 Apr;29(4):193-5

2. Hein HO, Sorensen H, Suadicani P, Gyntelberg F. Alcohol consumption, Lewis phenotypes, and risk of ischaemic heart disease. Lancet 1993 Feb 13;341(8842):392-6

3. Petit JM, Morvan Y, Mansuy-Collignon S, Viviani V, et al. Hypertriglyceridaemia and Lewis (A-B-) phenotype in non-insulin-dependent diabetic patients. Diabetes Metab 1997 Jun;23(3):202-4

4. Clausen JO, Hein HO, Suadicani P, et al. Lewis phenotypes and the insulin resistance syndrome in young healthy white men and women. Am J Hypertens 1995 Nov;8(11):1060-6





List All Diseases in Database






2014-12-19: Current Date 20:25:4 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.