PATHBASE
A database of blood group correlations to common diseases



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Food poisoning


Description:Anyone can get food poisoning. But certain blood types are naturally more susceptible, because of their tendency toward a weakened immune system. In particular, Type A and Type AB are more likely to fall prey to Salmonella food poisoning, which is usually the result of leaving food uncovered and unrefrigerated for too long. Furthermore, the bacteria will be harder for Type A and Type AB to get rid of once they've found a home in their systems.Type Bs, who are generally more susceptible to inflammatory diseases, are more likely to be severely affected when they eat food that is contaminated with the Shigella organism, a bacteria found on plants that causes dysentery. It appears that many of the variants of E. coli have developed individualized tastes for different ABO blood types. Even their 'strategies' differ from blood type to blood type:

Attachment -Type A: Many of the worse forms of E. coli express rope-like bundles of filaments, referred to as bundle-forming pili (BFP). These rope-like bundles allow them to attach to the lining of the intestines. These dangerous E. coli have suction-cup like lectins on their pili that attach to the various sugars (glycoproteins or glycolipids) comprising the polysaccharides of the intestinal mucus lining. Many of these sugars are, in fact, particular ABO antigens. For example, certain E. coli strains that colonize the human digestive tract express lectins specific for different glycolipids, called a globoseries. One such glycolipid, globo-A, is restricted to individuals of Blood Type A with a positive secretor state.

Mimicry- Type B and Type AB: Many forms of E. coli capable of causing diarrhea are immunologically B-like. That is, they possess an antigen on their surface that resembles the antigen which conveys Type B blood. Several studies show a higher number of Type B and Type AB people (who cannot manufacture anti-B antibodies) being afflicted with E. coli-caused gastroenteritis. In one study, 148 Egyptian patients were studied for parasitic and bacterial infections in relation to ABO blood types. There was a significant relationship between Blood Type B, and an excessive number among cases of E. coli (46.15%). The expected frequency of Type B should have been around 11%.

It has been hypothesized for years that the reason certain individuals manufacture antibodies to opposing blood types is a result of inapparent immunization by bacterial antigens in the gut. The hypothesis that naturally occurring anti-B (in those individuals who have Type O or Type A blood) protects against Type B-like E. coli infection, was verified in a second study that looked at the blood types of 115 patients with E. coli infection, and compared them with three control populations: 138 patients with infection due to other organisms; 23,135 hospitalized patients; and 40,038 normal blood donors. The incidence of Type B and Type AB, who cannot make anti-B antibodies, in the E. coli infection group was significantly higher than in those with Type A and Type O, who can make anti-B antibodies.

Interaction- Type O: There is an association of Type O blood with the severity of the diarrhea that results from E. coli infection. During studies of diarrhea due to Escherichia coli in 316 adult volunteers, ABO and Rh blood type determinations were examined, looking for differences in the severity of illness associated with certain blood groups. Volunteers with Type O blood had a significantly higher attack rate for diarrhea than those with other blood types. The authors in this case speculated that there was an interaction between the Type O blood substance and the toxin produced by the bacteria.
References:1.Springer GF. Role of human cell surface structures in interactions between man and microbes. Naturwissenschaften. 1970 Apr;57(4):162-71.

2.Yang N, Boettcher B Development of human ABO blood group A antigen on Escherichia coli Y1089 and Y1090. Immunol Cell Biol 1992 Dec;70 ( Pt 6):411-6

3.Lindstedt R, Larson G, Falk P, Jodal U, Leffler H, Svanborg C The receptor repertoire defines the host range for attaching Escherichia coli strains that recognize globo-A. Infect Immun 1991 Mar;59(3):1086-92

4.Gabr NS, Mandour AM Relation of parasitic infection to blood group in El Minia Governorate, Egypt. J Egypt Soc Parasitol 1991 Dec;21(3):679-83

5.Wittels EG, Lichtman HC Blood group incidence and Escherichia coli bacterial sepsis Transfusion 1986 Nov-Dec;26(6):533-5

6.Black RE, Levine MM, Clements ML, Hughes T, O'Donnell S Association between O blood group and occurrence and severity of diarrhoea due to Escherichia coli. Trans R Soc Trop Med Hyg. 1987;81(1):120-3.





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PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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