PATHBASE
A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Cystitis, Infectious (bladder and urinary tract infection)


Description:There is good evidence that if you are Type B or Type AB, you are more susceptible to cystitis. That's because the most common bacteria that produce infections, such as E. coli,

ABH non-secretors have a higher incidence of urinary tract infections. They also have a greater chance of having an excessive immune raction, resulting in scarring of the kidneys.

Pseudomonas, Proteus and Klebsiella, possess a B-like appearance, and Type B and Type AB produce no anti-B antibodies.

Group B has a slight increase in risk for kidney disease in general.

ABH non-secretors are at a greater risk for recurrent urinary tract infections (UTI) and are much more likely to develop renal scars. This susceptibility is even greater among the Lewis negative subset (Le (a-b-)). The ABH secretor phenotype conveys a measure of protection; cutting the risk of recurrent UTI by greater than 50% and dramatically decreasing the likelihood that renal scars will develop.

ABH non-secretors appear to be at extra risk for recurrent urinary tract infections. In one study of women with recurrent UTI, 29 % of the women were the Lewis (a+ b-) non-secretor phenotype, while another 26% of the women were Lewis (a- b-) recessive phenotype. When the women with ABH non-secretor and recessive phenotypes were combined and considered collectively, the odds ratio (an estimate of relative risk of recurrent urinary tract infection) for those without the secretor phenotype (Lewis (a-b+) was 3. (1-5)

A form of synergy also appears to exist between UTI risk, secretor status and the lack of ability to create anti-B isohemagglutinin. Essentially, blood group B and AB and the non-secretor phenotype seem to work together to increase the relative risk of recurrent UTI among these women. (6) Evidence also indicates that women and children with renal scarring subsequent to recurrent UTI and pyelonephritis are more likely to be ABH non-secretors. (7-8) As many as 55-60% of all ABH non-secretors have been found to develop renal scars, even with the regular use of antibiotic treatment for UTI whereas as few as 16% of ABH secretors will develop similar renal scarring. (9)

This tendency to scarring does not seem to be dictated as much by the aggressiveness of the bacterial infection, but by the more aggressive inflammatory response created by ABH non-secretors against the bacterial infection. The levels of C-reactive protein, erythrocyte sedimentation rate and body temperature are significantly higher in non-secretors than in secretors (p less than 0.04) with recurrent UTI. As a consequence, non-secretors seem to self inflict to a degree the renal scarring secondary to their acute phase inflammatory response. (10)
References:1. Sheinfeld J, Schaeffer AJ, Cordon-Cardo C, et al. Association of the Lewis blood-group phenotype with recurrent urinary tract infections in women. N Engl J Med 1989 Mar 23;320(12):773-7

2. Similar findings by other researchers support this over representation of recurrent UTI among non-secretors both in women and children.

3. May SJ, Blackwell CC, Brettle RP, MacCallum CJ, Weir DM. Non-secretion of ABO blood group antigens: a host factor predisposing to recurrent urinary tract infections and renal scarring. FEMS Microbiol Immunol 1989 Jun;1(6-7):383-7

4. A, Nudelman E, Clausen H, et al. Binding of uropathogenic Escherichia coli R45 to glycolipids extracted from vaginal epithelial cells is dependent on histo-blood group secretor status. J Clin Invest 1992 Sep;90(3):965-72

5. Jantausch BA, Criss VR, O'Donnell R, et al. Association of Lewis blood group phenotypes with urinary tract infection in children. J Pediatr 1994 Jun;124(6):863-8

6. Kinane DF, Blackwell CC, Brettle RP, et al. ABO blood group, secretor state, and susceptibility to recurrent urinary tract infection in women. Br Med J (Clin Res Ed) 1982 Jul 3;285(6334):7-9

6. May SJ, Blackwell CC, Brettle RP, MacCallum CJ, Weir DM. Non-secretion of ABO blood group antigens: a host factor predisposing to recurrent urinary tract infections and renal scarring. FEMS Microbiol Immunol 1989 Jun;1(6-7):383-7

7. Lomberg H, Hellstrom M, Jodal U, Svanborg Eden C. Secretor state and renal scarring in girls with recurrent pyelonephritis. FEMS Microbiol Immunol 1989 Jun;1(6-7):371-5

8. Lomberg H, de Man P, Svanborg Eden C. Bacterial and host determinants of renal scarring. APMIS 1989 Mar;97(3):193-9

9. Jacobson SH, Lomberg H. Overrepresentation of blood group non-secretors in adults with renal scarring. Scand J Urol Nephrol 1990;24(2):145-50

10. Lomberg H, Jodal U, Leffler H, et al. Blood group non-secretors have an increased inflammatory response to urinary tract infection. Scand J Infect Dis 1992;24(1):77-83





List All Diseases in Database






2014-12-19: Current Date 23:33:0 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.