PATHBASE
A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Myocardial infarction


Description:Claudication shows a lower incidence of group O over other ABO groups.

An Italian study in 1975 on 746 patients with high blood pressure, 3258 with congenital heart disease, and 4503 with a history of heart attack, found a significant lack of patients with Blood Type O, and a significant excess of Blood Type A in patients with myocardial infarction. The study also showed an excess of Blood Type A patients with high blood pressure, and very few patients who were Blood Type B. (5)

A study of 255 women published in the Journal of the American Medical Association originally to study the effects of smoking on the rates of heart attack in women also found several other factors significantly associated with heart attacks in this group, including hypertension, angina pectoris, family history, diabetes mellitus, and Blood Type A. (6)

A 1985 study looked at blood type and heart attacks in two different age groups. The patients were divided into two groups: those who were 65 year old and older, and younger patients. The predominance of Blood Type A in patients with cardiac infarction was 'highly significant' in both age groups (P less than 0.005). This study was unique in that other risk factors, such as smoking, high blood pressure, diabetes, smoking, and high cholesterol levels were excluded from the study. When the researchers looked specifically at the more elderly population, the predominance of Blood Type A in the older patients with cardiac infarction was even higher (P less than 0.001). The researchers concluded that 'Our investigation strongly suggests the existence of a genetic factor associated with Blood Type A, and independent of the other risk factors which are also responsible for a greater incidence of cardiac infarction. (7)

Type A behavior in men who have had a myocardial infartction' shows a higher incidence of group O over the other ABO groups.

Data allows the conclusion that the ABH non-secretor phenotypes are a risk factor for myocardial infarction, this is particularly true for recessive Lewis blood types and even more so among men than women. ABH secretors seem to have been given a bit of genetic resistance against heart disease while Lewis negative individuals appear to be at the highest risk for CHD.

This finding was reported in the Copenhagen Male study and replicated in the NHLBI Family Heart Study. Eight percent of men with the Lewis (a-b-) phenotype had a history of non-fatal myocardial infarction (among Lewis positive men the frequency was only 4%). But even worse, research showed that men with Lewis (a-b-) had an increased risk of death from ischemic heart disease (IHD) (IHD case fatality rate (RR =2.8 (1.5-5.2), P = 0.01)) compared with others. Adjusted for age, relative risk climbed even higher to 4.4 (1. 9-10.3), P < 0.001, and for all causes of mortality RR = 1.6 (1.0-2.6), P < 0.05.
The relation of total serum alkaline phosphatase and serum cholesterol in convalescing patients of myocardial infarction with secretor status and blood groups have been studied. Serum cholesterol and alkaline phosphatase levels showed significant difference in secretors (98) and nonsecretors (56) in myocardial groups. Total cholesterol and total serum alkaline phosphatase levels showed significant difference in secretors when blood groups A and O are compared. While in nonsecretors, significant values obtained in A/O, A/B for cholesterol and A/B, A/AB for alkaline phosphatase levels. Xx.>



The influence of erythrocytes of different blood groups on the intestinal isoenzyme of alkaline phosphatase (EC 3.1.31.1) was investigated. Binding of the enzyme to erythrocyte membranes was demonstrated by sedimentation experiments, by enzyme electrophoresis, by gel chromatography and immunologically using a modified Coombs technique. We found that red cells of blood group A bind almost all intestinal alkaline phosphatase; erythrocytes of blood group B or O to a much lesser degree. This is in accordance with the fact that intestinal alkaline phosphatase is found more frequently in the serum of individuals of blood group O or B than in serum of persons of blood group A. We conclude that underlying the described blood group dependent differences in synthesis of intestinal alkaline phosphatase lies a mechanism involved in the regulation of the activity of intestinal alkaline phosphatase in human serum. Xz.>
References:1. Hein HO, Sorensen H, Suadicani P, Gyntelberg F. The Lewis blood group--a new genetic marker of ischaemic heart disease. J Intern Med 1992 Dec;232(6):481-7

2. Indian Heart J 1989 Mar;41(2):82-85 Total serum alkaline phosphatase (SAP) and serum cholesterol in relation to secretor status and blood groups in myocardial infarction patients. Mehta NJ, Rege DV, Kulkarni MB

3. Clin Chim Acta 1980 Nov 20;108(1):81-87 Intestinal alkaline phosphatase and the ABO blood group system--a new aspect.Bayer PM, Hotschek H, Knoth E

4. South Med J 1991 Feb;84(2):214-218 Relationship between blood groups and behavior patterns in men who have had myocardial infarction. Neumann JK, Chi DS, Arbogast BW, Kostrzewa RM, Harvill LM

5.Galeazzi L, Gualandri V. [ABO blood-group phenotypes and pathogenesis of cardiovascular diseases. Congenital, rheumatic and coronaric heart disease and arterial hypertension]. Ital Cardiol 1975;5(5):744-751

6. Stolley PD, Shapiro S. Myocardial infarction in women under 50 years of age. JAMA 1983 Nov 25;250(20):2801-2806

7.Platt D, Muhlberg W, Kiehl L, Schmitt-Ruth R. ABO blood group system, age, sex, risk factors and cardiac infarction. Arch Gerontol Geriatr 1985 Oct;4(3):241-249





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2014-7-31: Current Date 21:56:23 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.