A database of blood group correlations to common diseases
Total number of records: 145 Matching records: 1
|Description:||Aggregation of strains of Streptococcus rattus, Strep. mutans and Strep. salivarius by saliva from individuals of blood groups A, B and O was investigated. Blood group A salivas had a significantly higher aggregation activity with Strep. rattus than blood group B salivas (P less than 0.05). However, Strep. mutans and Strep. salivarius were better aggregated by blood group B saliva and this was significant for Strep. mutans (P less than 0. 05). |
For all three strains, the variance within blood group O was too large to give significant differences with either blood group A or B. The blood group A-specific carbohydrate, N-acetyl-D-galactosamine, inhibited aggregation of Strep. rattus, but not of the other strains. The blood group B-specific carbohydrate, D-galactose, inhibited aggregation of Strep. mutans but not of Strep. rattus or Strep. salivarius. L-Fucose, specific for blood group O failed to inhibit aggregation of any of the three strains. These findings suggest that blood group-specific substances may be involved in bacterial aggregation. (2)
In a prospective study of maternal genital colonization with group B streptococci (GBS) at the time of delivery, epidemiological data, including blood type (ABO group), were recorded for the 1,062 patients studied. Blood type B was found in a statistically significant higher proportion of patients colonized with GBS (28%) compared with the total population (16.4%) (P less than .005, X2 = 8.43). Women with blood type B were twice as likely to be colonized as those with types O or A. Hypotheses to explain this observation include the possibilities that GBS possess a B-like antigen, rendering parturients who lack anti-B antibody at increased risk for GBS colonization, or that GBS possess a receptor site for B surface antigens. One may speculate that a mutation toward an affinity for the human ABO blood group type B accounts for the advent of the group B Streptococcus as a significant perinatal pathogen. (3)
|References:||1. Haverkorn MJ, Goslings WR. Streptococci, ABO blood groups, and secretor status. Am J Hum Genet. 1969 Jul;21(4):360-75|
2.Ligtenberg AJ, Veerman EC, de Graaff J, Nieuw Amerongen AV. Saliva-induced aggregation of oral streptococci and the influence of blood group reactive substances. Arch Oral Biol. 1990;35 Suppl:141S-143S.
3.Pediatrics 1978 Oct;62(4):504-509 Maternal ABO blood group type B: a risk factor in the developement of neonatal group B streptococcal disease. Regan JA, Chao S, James LS
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PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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