PATHBASE
A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Polyps, Colon


Description:Colon polyps express large amounts of ABO antigens.(1) However as these polyps progress to colon cancer, the amount of ABO antigens in them drops dramatically or disappears altogether. (2)

As cells progress towards cancer, they undergo a process of 'de-differentiation.' For example, a healthy cell lining the colon wall is specialized for its unique job requirement by being differentiated for the job it needs to do. In the DNA of that healthy colon cell, all the other unneeded genes are turned off, or repressed. Concurrently, a healthy skin cell has its special genes left on and other unneeded genes turned off. As a cell mutates, the control repressing these unneeded genes is undermined and the cells start to lose their differentiation for special characteristics. This loss of differentiation can be gradual; often cells begin to mutate while still keeping some of their original function. We sometimes call this stage 'pre-malignancy.' As the mutations progress and deepen, the cells now lose more and more function, becoming more and more 'undifferentiated' until they are a complete junk cell with no function whatsoever, other than to reproduce and spread.
References:1. Itzkowitz SH Blood group-related carbohydrate antigen expression in malignant and premalignant colonic neoplasms. J Cell Biochem Suppl 1992;16G:97-101

2. Schoentag R, Primus FJ, Kuhns W ABH and Lewis blood group expression in colorectal carcinoma. Cancer Res 1987 Mar 15;47(6):1695-700

3. Jordinson M, et al Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells. Gut. 1999 May;44(5):709-714.

4. Itzkowitz SH Blood group-related carbohydrate antigen expression in malignant and premalignant colonic neoplasms. J Cell Biochem Suppl 1992;16G:97-101





List All Diseases in Database






2014-11-22: Current Date 10:46:5 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.