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PATHBASE


A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Asthma


Description:The MN variation of the MN blood grouping subtype is associated with a higher incidence of bronchial asthma.

Group B is associated with a higher incidence of asthma. Group O with a slightly lower incidence. A link to group A has been shown but it is weak.

Among coal miners, asthma was significantly related to non-secretor phenotype. In this population, significantly lower lung function and higher likelihood of wheezing is especially prevalent among Lewis-negative or non-secretor subjects with blood group O. (1) Independent findings suggest that the ability to secrete ABH antigens might decrease the risk of COPD. Non-secretors have been found to have significantly greater impairment of forced expiration. ABH non secretors have lower mean values of forced expiratory volume in one second as a percentage of forced vital capacity (FEV1/FVC%) and a significantly larger proportion of them had aberrant values, defined as FEV1/FVC% less than 68. (2)

The objectives of the present study were to assess the role of all three systems, Lewis (Le), salivary ABH secretor (Se), and red cell blood group ABO, on lung function, wheezing, and asthma in a cohort of 228 coal miners studied cross-sectionally, considering the potential modifying effect of environmental factors on these associations. Asthma was significantly related to nonsecretor phenotype. Significantly lower lung function and higher prevalences of wheezing and asthma were observed in Lewis-negative or nonsecretor subjects of blood group O. Lewis-positive, salivary ABH secretors who have these two fucoses represent 70% of Caucasians. ABO, Lewis, and secretor phenotypes did not account for the potential genetic heterogeneity of subjects toward smoking, but alcohol consumption appeared to exert a protective effect on lung function in Lewis-negative subjects (10% of Caucasians). If confirmed in other populations, the magnitude of the effects observed regarding low lung function in Lewis-negative ABH nonsecretors, and the protective effect of Lewis negative on the deleterious effect of alcohol, may be of clinical importance.
References:1. Kauffmann F, Frette C, Pham QT, et al. Associations of blood group-related antigens to FEV1, wheezing, and asthma. Am J Respir Crit Care Med 1996 Jan;153(1):76-82

2. Cohen BH, Bias WB, Chase GA, et al. Is ABH nonsecretor status a risk factor for obstructive lung disease. Am J Epidemiol 1980;3:285-91





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2015-7-3: Current Date 12:44:36 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2015.


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