A database of blood group correlations to common diseases
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|Description:||In general, Type Os are more inclined to Candida hypersensitivity than other blood types, with the greatest susceptibility being for Type O non-secretors.|
Overall, non-secretors have a much higher rate of candidiasis. The protective effect afforded by the secretor gene might be due to the ability of glycocompounds in the body fluids of secretors to inhibit adhesins on the surface of the yeast. Non-secretor saliva may not only fail to prevent attachment of Candida sp. but may actually promote the binding of Candida sp. to tissue.
In one study, among individuals with NIDDM, 44% of non-secretors were oral carriers of this yeast. The inability to secrete blood group antigens in saliva also appears to be a risk factor in the development of, or persistence of chronic hyperplastic candidiasis. In one study, the proportion of non-secretors of blood group antigens among patients with chronic hyperplastic candidiasis was 68%. Women with recurrent vaginal yeast infections are also much more likely to be non-secretors.
Although non-secretors make up only about 26% of the population, they are significantly over represented among individuals with either oral or vaginal Candida infections, making up almost 50% of affected individuals. (1) The inability to secrete blood group antigens in saliva also appears to be a risk factor in the development of, or persistence of chronic hyperplastic Candidosis. In one study, the proportion of non-secretors of blood group antigens among patients with chronic hyperplastic Candidosis was 68%.
|References:||1. Thom SM, Blackwell CC, MacCallum CJ, et al. Non-secretion of blood group antigens and susceptibility to infection by Candida species. FEMS Microbiol Immunol 1989 Jun;1(6-7):401-|
2. Lamey PJ, Darwazeh AM, Muirhead J, et al. Chronic hyperplastic candidosis and secretor status. J Oral Pathol Med 1991 Feb;20(2):64-7
3. Cameron BJ, et al Blood group glycolipids as epithelial cell receptors for Candida albicans. Infect Immun. 1996 Mar;64(3):891-6.
4. Essery SD, et al Detection of microbial surface antigens that bind Lewis(a) antigen. FEMS Immunol Med Microbiol. 1994 Jun;9(1):15-21.
5. Tosh FD, et al Characterization of a fucoside-binding adhesin of Candida albicans. Infect Immun. 1992 Nov;60(11):4734-9.
6. Thom SM, et al Non-secretion of blood group antigens and susceptibility to infection by Candida species. FEMS Microbiol Immunol. 1989 Jun;1(6-7):401-5.
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PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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