PATHBASE
A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 1

Auto-immune disease, Multiple sclerosis


Description:MS is an example of the Type B tendency to contract unusual slow-growing viral and neurological disorders. The Type B association may explain why many Jews, with high numbers of Type B blood, suffer these diseases more than others. Some researchers believe that multiple sclerosis and Lou Gehrig's disease are caused by a virus, contracted in youth, that has a B-like appearance. The virus cannot be combatted by the Type B immune system since it can't produce anti-B antibodies. The virus grows slowly and without symptoms until twenty or more years after it has entered the system Type ABs are also at risk for these B-like diseases, since their bodies do not produce anti-B antibodies.Type O and Type A seem to be relatively immune by virtue of their strong anti-B antibodies.

Rh+ shows an increased incidence of multiple sclerosis.

Type AB is at greater risk of rapidly profressing MS. This is the first study on genetic markers in Mexican Mestizos with multiple sclerosis (MS). Patients were born in Mexico, had no family history of MS are middle-class, and have a high-level education. HLA class I, class II determinants, C2, C4, BF, GLO-1, ABO, and Rb red cell systems were analyzed and compared with results of 295 controls. The polygenicity of the disease is emphasized by the excess of AB group carriers (pc = 0.01). (1)

Group B angainPoligenetically determined predisposition to multiple sclerosis (MS) defines the way of immunological reaction to environmental factors and leads to clinically manifest disease. Our results demonstrate that the MS patients differ from the normal subjects with regard to the Rh, ABO and Lewis erythrocytic antigens. The Rh positive factor was present in 95.55% of the MS patients compared to 84.29% of the controls, whereas the Rh negative factor was found in only 4.45% of the MS patients and 15.71% of the healthy subjects. The blood group O was demonstrated in 22.22% of the MS patients compared to 40.42% of the healthy persons. The MS patients had the blood group A in 15.11% of the cases as opposed to 43.99% of the subjects in the control groups. The blood group B was found in 22.22% of the MS patients compared to 11.10% of the controls. The distribution of the Lewis system in the MS patients was also demonstrated to be different from that in the general population. The MS patients were found to have less frequently the Le a+b- phenotype (11.12%) and more frequently Le a- b- (13.33%) compared to the healthy subjects who had the Le a+b- phenotype in 12.00% of the cases and Le a- b- in 5.00%. (2)

Inspired by the widely discussed problem of a possible genetic background of multiple sclerosis we have undertaken a trial of determining the relationship between the hereditary trait conveyed by a single gene, i.e. the salivary secretion or nonsecretion of blood group substances, and the occurrence of this disease. The investigations have shown that in the population of western Poland the nonsecretors of blood group substances into their saliva have a statistically significant chance of developing multiple sclerosis than secretors of these substances. (4)
Sera from multiple sclerosis patients show a deficit of intestinal alkaline phosphatase (serum type Pp2) by comparison with normal sera. This is not due to variation in ABO frequency, since the specimens from patients and normals are matched for ABO frequency, and it is not due to differences in secretor frequency, but represents a real dificit for Pp2 in patients with multiple sclerosis, particularly noticeable in group O individuals. 5.>
References:1. Gorodezky C, Najera R, Rangel BE, Castro LE, Flores J, Velazquez G, Granados J, Sotelo J. Immunogenetic profile of multiple sclerosis in Mexicans. Hum Immunol 1986 Aug;16(4):364-74.

2.Neurol Croat 1991;41(1-2):3-12 Genetic markers in the blood of multiple sclerosis patients. Markovic S, Bozicevic D, Simic D, Brzovic Z

3.Zh Nevropatol Psikhiatr Im S S Korsakova 1983;83(3):42-6 [Genetic markers of erythrocyte blood groups in multiple sclerosis among the Armenian population].Darbinian VZ, Nersisian VM, Martirosian IG.

4.Eur Neurol 1981;20(1):52-5 Salivary secretion of blood group substances in multiple sclerosis patients.Wender M, Przybylski Z, Stawarz M, Chmielewska U.

5.Clin Genet 1975 Jan;7(1):77-82 Serum alkaline phosphatase in patients with multiple sclerosis.Papiha SS, Roberts DF.

6.Warner HB, Merz GS, Carp RI. Blood group frequencies in multiple sclerosis populations in the United States. Neurology. 1980 Jun;30(6):671-3.





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PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.