PATHBASE
A database of blood group correlations to common diseases



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Glaucoma


Description:ABH non-secretors have a higher incidence of glaucoma.

here are some blood type associations with glaucoma. A series of 474 mixed cases of glaucoma was assessed to determine whether there were any genetic differences between different types of glaucoma. A careful distinction was made between chronic open angle glaucoma (COAG), acute and chronic angle closure glaucoma, ocular hypertension, low tension glaucoma, patients with large cup disc ratios, and various types of secondary glaucoma including pseudoexfoliation of the lens capsule, uveitic and traumatic glaucoma. Using ABO blood groups, Rhesus groups and ABH secretion or non-secretion the researchers identified certain differences.

The differences were significant decrease in Rh-negative patients in chronic closed angle glaucoma. Secretors had lower rates of in ocular hypertension and fewer HB secretors in patients with chronic open angle glaucoma. There was a significant lack of type A secretors and increase type B secretors in both pseudoexfoliation with raised intraocular pressure compared with chronic closed angle glaucoma.
References:1. Brooks AM, Gillies WE. Blood groups as genetic markers in glaucoma. Br J Ophthalmol 1988 Apr;72(4):270-3





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