A database of blood group correlations to common diseases

Total number of records: 145 Matching records: 1

Allergy, hay fever

Description:Group B is associated with a higher incidence of hay fever.

In 239 German patients with atopic conditions (atopic dermatitis, hay fever, allergic rhinitis, bronchial asthma, and acute urticaria) the phenotype and gene distribution of 15 genetic blood polymorphisms (ABO, MNSs, rhesus, P, Kell, Duffy, Kidd, Hp, Gc, Gm, Inv, aP, PGM1, EsD, and 6-PGD) were analyzed and compared with those in 151 selected controls (individuals clinically free of allergic conditions and without allergy in the family history). The incidence of blood group antigens A and B was higher in patients than in controls. These observations are in accordance with the results of previous studies in other populations.(1)

The frequency distribution of the blood group phenotypes ABO was examined in retrospect in a selected group of 241 Patients with grass pollen hayfever. A relative deficiency in blood group O was found, with a shift toward an over-represented B-phenotype as compared to the general population. This shift appeared to be largely due to the contribution from the female patients with pollinosis. Comparison with literature data confirmed a lower frequency of the O-phenotype in atopic patients in general, irrespective of the specific sensitivities.(2)

The aim of this study was to investigate the role of erythrocyte antigens of several systems (ABO, Rh, MNSs, P, Duffy, Kell) in the predisposition to and development of respiratory atopic disease (RAD) in the Georgian population. Two hundred and ninety-three patients with RAD, 83 patients with intrinsic bronchial asthma (IBA) and 215 healthy subjects were included. Associations between blood groups and RAD (atopic bronchial asthma [ABA] and pollinosis), the severity of the disease and the type of sensitization were established, involving the ABO, MNSs and Duffy systems. The groups at higher risk for the development of RAD were carriers of phenotypes O(I), MN, O(I)MN, MNFya(-), O(I)Fya(-) and O(I)MNFya(-). Resistance to RAD was associated with phenotypes A(II), AB(IV), N, Fya(+) and B(III)N. The risk for the development of severe ABA was higher in patients with B(III), M and B(III)M phenotypes. For the patients with groups O(I) and MN, a mild to moderate degree of severity of ABA was more characteristic. In healthy Georgians, erythrocyte polymorphism was not associated with immune status. In cases of house dust allergy, erythrocyte antigen P1 was associated with high levels of IgE. In patients with RAD higher B-lymphocyte counts were associated with O(I) and lower counts with A(II). (3)
References:1. Hum Genet 1979 Jul 18;49(3):337-348 Associations between atopic diseases and the polymorphic systems ABO, Kidd, Inv and red cell acid phosphatase. Brachtel R, Walter H, Beck W, Hilling M

2. Allerg Immunol (Leipz) 1989;35(3):167-172 Blood groups ABO and grass-pollen hayfever. Koers WJ, Houben GF, Berrens L

3. J Investig Allergol Clin Immunol 1995 Jan;5(1):35-39 Erythrocyte antigens as immunogenetic markers of respiratory atopic diseases in Georgians. Khetsuriani NG, Gamkrelidze AG

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2014-4-24: Current Date 2:53:59 GMT: Current Time

PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2011.