A database of blood group correlations to common diseases
Total number of records: 145 Matching records: 1
|Description:||The hypothesis is put forward that the low frequency of A and high frequency of O blood group genes in the Icelandic human population is the result of a selective disadvantage of A during severe smallpox epidemics. The hypothesis is supported by data from India in 1965-6, which show a marked selective effect of a smallpox epidemic against the phenotypes A and AB (Vogel & Chakravartti, 1971). The conclusion is drawn that the present-day ABO blood group gene frequencies of the Icelandic population should be used with reservation as markers in the study of the origin of the Icelanders. (1)|
The effect of antigenic polymorphism of the ABO-system blood groups on the character of the vaccinal process after immunization against natural smallpox was investigated. The increased susceptibility of persons possessing A antigen to the harmful effect of smallpox vaccine virus is due to hereditary rather than to acquired factors. The leukocytes of peripheral blood of these persons showed a poorer binding capacity with respect to the smallpoxvaccine virus; they also exhibited a high rate of chromosomal aberration after vaccination, resulting to some extent from increased proliferative ability of the cells. (2)
|References:||1. Adalsteinsson S. Possible changes in the frequency of the human ABO blood groups in Iceland due to smallpox epidemics selection. Ann Hum Genet. 1985 Oct;49 ( Pt 4):275-81.|
2.Sokhin AA, Lebedinskii AP, Frolov AK, Frolov VK, Sotnik AY, Lysakova VI. The mechanism of group differences in the character of the vaccinal process in immunization against natural smallpox. J Hyg Epidemiol Microbiol Immunol. 1977;21(3):335-40.
3.Kellermann G. Further studies on the ABO-typing of ancient bones. Humangenetik. 1972;14(3):232-6
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2014-12-20: Current Date 14:41:52 GMT: Current Time
PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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