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Ulcer, Peptic


Description:The characteristics of peptic ulcer and non-ulcer dyspepsia in young men were studied in 202 consecutive conscripts who attended Central Military Hospital in Helsinki because of long-standing upper abdominal complaints. Active peptic ulceration (APU) was found in 48 patients, inactive peptic ulcer disease (IPU) was diagnosed in 77 patients, non-ulcer dyspepsia (NUD) was diagnosed in 52 patients. In 25 cases the reason for symptoms was another disease, and these patients were excluded from the study. A control series (CON) consisted of 30 symptomless healthy young male volunteers. . In conclusion, the status of gastroduodenal mucosa, gastric secretion pattern and distribution of some genetic markers in patient series indicate that young onset peptic ulcer and non-ulcer dyspepsia are two separate entities. Helicobacter-positive antrum gastritis is the best determinant of ulcer risk, but also high S-PGI, Lewisa+ phenotype, non-secretor status and O-blood group are signs of increased risk of peptic ulcer.
The concentrations of gastrin were measured by the RIA method in the sera of 121 healthy Greek volunteers of both sexes and of different ABO blood groups, aged 20--70 years. The determinations took place in a fasting state in all the individuals and 10 min and 40 min after a test meal in 42 of them. No significant differences were found in the mean concentrations of gastrin in the fasting state and after the meal between the various ABO groups. There was an increase in the mean concentrations of gastrin in all the groups after the meal. Nevertheless, this was significant 40 min after the meal in the groups A and B whilst in the group O and in the groups A, B and AB considered together this significant increase had appeared already 10 min after the meal. 2.>
References:1. Scand J Gastroenterol Suppl 1991;186:33-44 Young onset peptic ulcer disease and non-ulcer dyspepsia are separate entities. Cederberg A, Varis K, Salmi HA, Sipponen P, Harkonen M, Sarna S

2. Acta Hepatogastroenterol (Stuttg) 1978 Dec;25(6):482-486 Serum gastrin concentrations in healthy people of the various ABO blood groups. Melissinos K, Alegakis G, Archimandritis AJ, Theodoropoulos G





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