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A database of blood group correlations to common diseases

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Description:While hyperacidity is more common in Type O and Type B, low stomach acid is typical in Type A and Type AB. It has long been known that low stomach acid production is frequent in Type A. In a 1955 study published in the British medical journal, Lancet, researchers studied the pattern of stomach acid secretion in patients with peptic ulcer, pernicious anemia, and stomach cancer. Of the 111 subjects examined, in the group experiencing both stomach cancer and a complete lack of stomach acid production, the ratios of Type A to Type O were almost 2 to 1. In 1959, the production of both stomach acid and pepsin was studied in both Blacks and Caucasians, and analyzed according to ABO blood type.

While the secretion of both gastric acid and pepsin was about the same for both races, substantial differences were found between the blood types. Impairment of stomach acid production was much more common in Type A than Type O, and the value of plasma pepsinogen was also higher in Type O over Type A. In a separate study, the same researcher also found that a lack of stomach acid was significantly more common among Type A individuals reporting digestive problems. Other studies done around the same time in India also showed differences in stomach acid production between Type O and Type A in response to a standardized test meal.

One reason that low stomach acid is linked to Type A blood may have to do with the role of Epidermal Growth Factor (EGF). EGF is a polypeptide hormone that stimulates the growth and repair of epithelial tissue. It is widely distributed in the body with high concentrations detectable in saliva, the prostate gland, and in the duodenum of the small intestine.

EGF also has the effect of decreasing gastric acid secretion. The receptor for EGF shares a similarity for the Blood Type A antigen; in tests, antibodies directed against the EGF receptor also bind to the Blood Type A antigen. This could play a role in the increased incidence of certain cancers with Type A, and also perhaps explain why stomach acid secretions are lower in Blood Type A than in the other blood types.

List All Diseases in Database

2018-5-20: Current Date 12:14:55 GMT: Current Time

PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
By Peter D'Adamo. Copyright 2001-2015.

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