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A database of blood group correlations to common diseases

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Otitis externa

Description:The outer ear canal expression of ABH human blood group antigens has been analyzed with a standardized routine histological procedure by monoclonal antibodies in the case of blood groups A and B, and a corresponding lectin in the case of blood group 0, respectively. In all 20 cases the blood groups were histochemically confirmed. Furthermore, Pseudomonas aeruginosa-specific inhibition experiments were performed with different sugar solutions as well as A-like substance incubating outer ear canal tissue sections with P. aeruginosa strain (No. 60) presenting lectin specificity for N-acetyl-galactosamine (GalNAc). P. aeruginosa lectins with GalNAc specificity apparently adhere to GalNAc as terminal blood group A determinant and indicate that patients presenting with blood group A may have a genetic predisposition to this form of otitis externa.
References:1. J Otorhinolaryngol Relat Spec 1995 May;57(3):148-152 Are ABH antigenic determinants on human outer ear canal epithelium responsible for Pseudomonas aeruginosa infections? Steuer MK, Hofstadter F, Probster L, Beuth J, Strutz J

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