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PATHBASE


A database of blood group correlations to common diseases



Total number of records: 145 Matching records: 2

Hypertriglcyeridemia (High triglycerides)


Description:One study showed that individuals who had a "B antigen" had higher triglyceride levels than expected. (75) This was again replicated in a second study, but interestingly, the investigators could not discount the effect of body size, noting that blood type B subjects were taller than non-B individuals by a mean value of 2.4 cm. (76)

The link between obesity, triglycerides, and 'bad' lipoproteins have been linked to blood type O. In a French study of blood donors, serum triglycerides and lipoproteins were shown to correlate with both obesity and blood type O in a study screening for cardio- or cerebro-vascular disease. (1)
The objective of the study was to examine the relation between protein intake and risk of ischemic heart disease. The researchers examined 80,082 nurses between the age of 34-59 and without a previous diagnosis of heart disease, stroke, cancer, high cholesterol, or diabetes. Intakes of protein and other nutrients were assessed with validated dietary questionnaires. The researchers documented 939 major instances of heart disease during 14 years of follow-up. After age, smoking and other risk factors were eliminated, high protein intakes were associated with a low risk of heart disease. The researchers concluded that "Our data do not support the hypothesis that a high protein intake increases the risk of heart disease. In contrast, our findings suggest that replacing carbohydrates with protein may be associated with a lower risk of heart disease." (35)

80,082 nurses were studied over 14 years so this is not a back yard study. To give you some history it was thought that a high protein/low carbohydrate diet CAUSED heart disease. This was debated by the naturopathic community at large, arguing that insulin (stimulated by our consumption of pasta/wheat/bread etc.) caused obesity and that our carbohydrates should come from fruits and vegetables. These foods are actually low in carbohydrates in comparison to grains.

The study concluded that a high carbohydrate diet increased the risk for heart disease however, when carbohydrates were replaced with protein the heart disease rate fell significantly.

This study would have been even more interesting if they had blood typed the subjects, and had accounted for which types of carbohydrates caused the problem. Undoubtedly they would have discovered that the rates of heart disease would have been higher in blood type O specifically when they consumed high-lectin containing grains such as wheat or corn, resulting in insulin resistance. High triglyceride levels have been linked to insulin resistance, a condition which affects one out of every four people in the U.S., or 80 million Americans, who are more prone to heart disease, even though they never may actually go on to develop diabetes.

Lectins have been extensively studied with respect to their 'insulin mimicking' effects. Perhaps the best studied lectin with regard to this is wheat germ agglutinin. (36,37,39,40) In addition, antibodies to bound wheat germ agglutinin have been found in the islet cells of the pancreas, which are responsible for the secretion of insulin. (38) In fact, it may be the type of carbohydrate (that is, whether it is lectin-containing grain or not) rather than the level of carbohydrate itself. If you are type O, you'll do better limiting your consumption of insulin mimicking lectins, thus keeping your weight and triglyceride levels low than necessarily watching your total cholesterol levels.
References:1. Terrier E, Baillet M, Jaulmes B. [Detection of lipid abnormalities in blood donors]. Rev Fr Transfus Immunohematol 1979 Mar;22(2):147-58

2. Contiero E, Chinello GE, Folin M. Serum lipids and lipoproteins associations with ABO blood groups. Anthropol Anz 1994 Sep;52(3):221-30

3. Borecki IB, Elston RC, Rosenbaum PA, Srinivasan SR, Berenson GS. ABO associations with blood pressure, serum lipids and lipoproteins, and anthropometric measures. Hum Hered 1985;35(3):161-70





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2015-5-28: Current Date 10:31:50 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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