PATHBASE
A database of blood group correlations to common diseases



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Cancer, Head and Neck, Salivary glands


Description:There is an association of group A with cancers of the head and neck, lip, tongue, salivary glands, gum and cheek.

As a general rule, a higher intensity of oral disease is found among ABH non-secretors. So it is not surprising that when it comes to precancerous, or cancerous changes to tissue of the mouth and esophagus, ABH non-secretors seem to fair worse than ABH secretors. This oral disease susceptibility is reflected in the occurrence of epithelial dysplasia, for example, which is found almost exclusively in the non-secretor group. (3)

Ductular epithelium and the epithelial components of benign Warthin's tumors have ABO (H) antigens, while the loss of antigen in the epithelial portion of the malignant Warthin's tumor is characteristic of epithelial neoplastic dedifferentiation. Loss of antigen in adenoid cystic and undifferentiated carcinomas of the parotid supports the concept that antigen is absent in epithelially derived malignant neoplasms. (2)

A strong association between salivary gland tumors and blood group A has been reported, but studies are few and have yielded contradictory results.
References:1. Vidas I, Delajlija M, Temmer-Vuksan B, et al. Examining the secretor status in the saliva of patients with oral pre-cancerous lesions. J Oral Rehabil 1999 Feb;26(2):177-82

2. Woltering EA, Tuttle SE, James AG, Sharma HM. ABO (H) cell surface antigens in benign and malignant parotid neoplasms. J Surg Oncol. 1983 Nov;24(3):177-9.

3: Garrett JV, Nicholson A, Whittaker JS, Ridway JC. Blood-groups and secretor status in patients with salivary-gland tumours. Lancet. 1971 Nov 27;2(7735):1177-9.





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2014-10-21: Current Date 9:31:7 GMT: Current Time


PathType is a searchable database of blood group and disease associations, clinical correlates and citations.
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