Recent news in the world of genetics: the chromosomal makeup of Santa Claus (also known as Saint Nicholas, or Father Christmas) has a very individual genetic structure. Far from the theory that Santa Claus does not exist, scientists have now discovered the generous saint is endowed with three extra chromosomes, explaining his very individual abilities and personality.
The most common genetic makeup of humans is 23 pairs, but Santa Claus has 3 additional chromosomes (known as Trisomy 25), which is believed to account for his high levels of activity around December 25th. In Europe this is more correctly known as Trisomy 24, the presence of three additional homologous chromosomes (having the same structural features and pattern of genes) in addition to the 23 typical pairs. Inhabitants of many European countries open their presents on Christmas Eve (24th December), hence the difference in nomenclature.
A study of children with acute leukaemia found a statistically significant difference in the blood groups of the patients depending on the type of leukaemia diagnosed. The multicenter study, published in the journal Pediatric hematology and oncology,(1) analysed blood group data in patients under 12 years with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)
In the ALL group there were more patients with blood group O and fewer patients with blood group A and B [confirming the results of an earlier study(2)]. In the AML group there were more patients with blood group A. The authors of the study conclude that "alteration in ABO antigens might be associated with an increased risk of ALL."(1)
This complements the information available in the Complete Blood Type Encyclopedia, which cites a study showing significantly lower incidence of acute (rapidly growing) leukaemia in females of blood group O, suggesting a sex-responsive gene near the ABO locus protecting females against acute leukaemia.(3)(4) In relation to diet there are also significant associations with acute leukaemia in women and consumption of milk, tea, beer, wine and beef.(5)
Individuals with the A2 phenotype have also been found to be significantly higher in a study of patients with chronic lymphocytic leukaemia.(6) Of other polymorphisms associated with leukaemia, slow metabolisers of the cytochrome P450 (CYP) polymorphisms 2C19 and 2D6 were found to be significantly higher in patients with acute leukaemia,(7) and folic acid metabolism.(8) Cytochrome P450 plays a central role in drug and xenobiotic metabolism as well as synthesis of stress hormones, metabolism of fat-soluble vitamins and polyunsaturated fatty acids. The CYP 2C19 slow metaboliser polymorphism was also found to affect personality traits in a study of Japanese females.(9) Of the 487 Japanese volunteers in the study, those found to have slow or fast metabolism of this cytochrome were compared. Female slow metabolisers had significantly lower scores for reward dependence, cooperativeness and self-transcendence than in fast metabolisers. In males, none of the seven personality traits was significantly different between slow and fast metabolisers. CYP 2C19 metabolizes sex hormones and 5-hydroxytryptamine, which are involved in multiple brain functions.
This column has news and commentary on research in the field of individuality, diet and health.
To see references, or to open the permalink, click on the [more] link at the bottom of the page.
I will be giving 2 lectures in Dublin at the RDS on October 28th and 29th 2006, talking about blood grouping, individuality and diet:
Sat. 28th, 12 noon - for health professionals
Sun 29th, 12 noon - for the public
There should be time for questions after the lectures, but I will also be around in the exhibition hall over the weekend on the Artisan Bread stand. Both lectures are free, but there is a charge to get in to the exhibition hall.
See you there...
Dear Dr. Greenfield, I am aged 39, O+ and following the group diet (approx. 2 years) and taking some supplements like basic O pack, Fucus, Hepatiguard, Harmonia, ARA6, garlic etc. As I was diagnosed with candida I have also eliminated all sugar and yeast products. I follow the yeast/fungus and colon health recommendations from Dr. Dadamo. I would like to know which supplement I could take to improve edema especially in my legs (not feet). I am slim and physically very active. My circulation isn't the best and I get sometimes cramps in my calves. Petra.
The cause of oedema and leg cramps can be related to imbalances of electrolytes in the blood. This can be due to various situations, but the first thing to check is the amount of salt and other sources of sodium in the diet. In the absence of kidney disease, butcher's broom (Ruscus aculeatus) can be helpful. If oedema continues it is generally advisable to get your local ND to run some blood and urine tests. For long term fungal infections it may also be useful to check for secretor status, as non-secretors of blood group O may be more prone to fungal dysbiosis.