A study of children with acute leukaemia found a statistically significant difference in the blood groups of the patients depending on the type of leukaemia diagnosed. The multicenter study, published in the journal Pediatric hematology and oncology,(1) analysed blood group data in patients under 12 years with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)
In the ALL group there were more patients with blood group O and fewer patients with blood group A and B [confirming the results of an earlier study(2)]. In the AML group there were more patients with blood group A. The authors of the study conclude that "alteration in ABO antigens might be associated with an increased risk of ALL."(1)
This complements the information available in the Complete Blood Type Encyclopedia, which cites a study showing significantly lower incidence of acute (rapidly growing) leukaemia in females of blood group O, suggesting a sex-responsive gene near the ABO locus protecting females against acute leukaemia.(3)(4) In relation to diet there are also significant associations with acute leukaemia in women and consumption of milk, tea, beer, wine and beef.(5)
Individuals with the A2 phenotype have also been found to be significantly higher in a study of patients with chronic lymphocytic leukaemia.(6) Of other polymorphisms associated with leukaemia, slow metabolisers of the cytochrome P450 (CYP) polymorphisms 2C19 and 2D6 were found to be significantly higher in patients with acute leukaemia,(7) and folic acid metabolism.(8) Cytochrome P450 plays a central role in drug and xenobiotic metabolism as well as synthesis of stress hormones, metabolism of fat-soluble vitamins and polyunsaturated fatty acids. The CYP 2C19 slow metaboliser polymorphism was also found to affect personality traits in a study of Japanese females.(9) Of the 487 Japanese volunteers in the study, those found to have slow or fast metabolism of this cytochrome were compared. Female slow metabolisers had significantly lower scores for reward dependence, cooperativeness and self-transcendence than in fast metabolisers. In males, none of the seven personality traits was significantly different between slow and fast metabolisers. CYP 2C19 metabolizes sex hormones and 5-hydroxytryptamine, which are involved in multiple brain functions.
This column has news and commentary on research in the field of individuality, diet and health.
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I will be giving 2 lectures in Dublin at the RDS on October 28th and 29th 2006, talking about blood grouping, individuality and diet:
Sat. 28th, 12 noon - for health professionals
Sun 29th, 12 noon - for the public
There should be time for questions after the lectures, but I will also be around in the exhibition hall over the weekend on the Artisan Bread stand. Both lectures are free, but there is a charge to get in to the exhibition hall.
See you there...
Dear Dr. Greenfield, I am aged 39, O+ and following the group diet (approx. 2 years) and taking some supplements like basic O pack, Fucus, Hepatiguard, Harmonia, ARA6, garlic etc. As I was diagnosed with candida I have also eliminated all sugar and yeast products. I follow the yeast/fungus and colon health recommendations from Dr. Dadamo. I would like to know which supplement I could take to improve edema especially in my legs (not feet). I am slim and physically very active. My circulation isn't the best and I get sometimes cramps in my calves. Petra.
The cause of oedema and leg cramps can be related to imbalances of electrolytes in the blood. This can be due to various situations, but the first thing to check is the amount of salt and other sources of sodium in the diet. In the absence of kidney disease, butcher's broom (Ruscus aculeatus) can be helpful. If oedema continues it is generally advisable to get your local ND to run some blood and urine tests. For long term fungal infections it may also be useful to check for secretor status, as non-secretors of blood group O may be more prone to fungal dysbiosis.
The PolyPill is back, and this time it is for real. The idea that everyone is sick and must be given a pharmaceutical medication to suppress disease symptoms (or markers in the blood) is so endemic in society that people will swallow such a concept daily.
Valentin Fuster, M.D., Ph.D., director of the Mount Sinai Cardiovascular Institute in New York, unveiled plans for the polypill in a press briefing at the World Congress of Cardiology.(1) Dr. Fuster said that patients would be more willing to take one pill than three pills. Spain is a victim of "industrial disease", that is, as the economy of the nation has improved, so has the incidence of heart disease.
Previous articles in this column about the PolyPill (2) (3) described details of a proposed single-dose daily medication for everyone over 55, with six ingredients: a statin, aspirin, folic acid, and three antihypertensives. The only ingredient in the original recipe that might actually be of some benefit (folic acid) has been removed, instead of combining it with other vitamins to reduce homocysteine.
The Spanish public will be the first to be given their daily dose of the new "preventative" medicine that is more likely to kill than cure them: a previous article in this column warned about the dangers of statins.(4) If "successful", the next victims will be the Chinese people.
One possible reason for peddling this medical cocktail could be that medicines with expired patents are no longer profitable to pharmaceutical companies. A patented combination of three of these defunct drugs is an unique product that could bring in money for the manufacturer. Meanwhile people in developing countries can feel justified in eating a junk food diet associated with increased wealth, as they are "protected" by their magic chemical concoction.