New research shows that sugar deposits may be the major cause of skin aging.

Skin science appears to have caught up with the humble sugar molecule. Wrinkles, sagging skin, and pigment deposits may stem less from the sun and more from one-way sugar molecules that we make as part of the aging process but cannot remove. With no small amount of serendipity, scientists call these wrong-way sugars ‘AGE molecules’ (the AGE stands for 'Advanced Glycation End-products').

AGE molecules are all around us, and often taste pretty good: Any time we brown an onion or caramelize sugar we are making AGE molecules. However, when you make these molecules under your skin, you’ll probably find much less to like about them.

Unlike most other complex sugars, AGE molecules are not easily removed from the body (Just think back to a time you tried to clean burnt sugar off of a piece of crockery!) And because they stay in place for years, the immune system can react to tissues they deposit in, causing inflammation, damage, and aging.

AGE molecules: Good on marshmallows, bad on people.


NAP recently released the next three D’Adamo Genoma Skin products, which now expands the line to four products:

The Day Light Face Crème is the original formula. We’ve has virtually 100% customer satisfaction with the product, including unsolicited comments from three users that it was the only product that worked on their facial rosacea.

To this base formula, I’ve added an AGE (Glycation inhibiting) toner, a rich night crème and a tissue cleanser that uses a few very interesting botanicals.

For the rest of the month, at my request, NAP is offering the complete set of four products at a savings of 50%. I asked that they try to do this so that as many people as possible can try the line. If you are looking for a great skin care line at an unbelievable price, either as a holiday gift for someone or even yourself, you might want to look into these products.

However, do it before December 31, 2008.

Many common folk also have a decidedly deterministic, perhaps fatalistic opinion of genetics. “It’s in the genes. There’s not much that you can do about it.” Nothing could be further from the truth; and although I can easily genuflect at the altar of genetics, I do not worship there. Your genes are just a reasonable plan for a particular way things can happen. Genes are just cogs in the wheel of life. They’re not here to cause disease; they are part of the structure of life.

For something so important to life, it’s quite surprising that there are so few of them; we humans have somewhere in the vicinity of 35,000 genes. Indeed when the human genome was first published scientists were incredulous to find that the number was so low (prior estimates were that there were at least 100,000.) And as if to prove that numbers aren’t everything, we humans don’t even measure up in this department as well; the average rice plant has around 40,000 genes. But then again, it’s not what you’ve got; it’s what you do with it.

It’s true, you can’t change your genes, but we are beginning to discover that Nature and Nurture do need each other. You can affect the way that your genes function. Matter of fact you do it all the time. For example, it may turn out that that dirty door knob your mother touched while she was pregnant with you may have had more influence in certain areas than all your DNA and RNA combined. As we move further into the meat and bones of this book, you will see how and why.

Genetics is typically thought of as being very complicated and difficult for the average person to understand, and this may well be true. However, the goal of this book is not to turn you into a geneticist, but rather give the advantages of conducting your life in such a way as to benefit from the knowledge of genetics.

Car showrooms can cast an interesting light on human behavior. While waiting my turn in a local dealership to buy a car, I had the chance to observe the interaction between the salesman and the young couple that he was attending to. Diligently he spouted out facts and details about the engine torque and horsepower, the suspension, and steering as the husband stood by obviously not understanding an iota of it all, but duly shaking his head and feigning great interest.

At the end of the soliloquy, our salesman of course asks if there are any questions. Not wanting to be seen as unintelligent, the young husband say no, he doesn’t have any. The young wife, on the other hand, had a burning question:

Where were the cup holders?

This simple interaction not only changed the way that I chose to write books, but changed my way of communicating in my medical practice. Most people who buy cars don’t want to repair them; they want to drive them. Yes, there is probably a very nice motor under the hood, but most intelligent people do not need convincing that there is a squirrel on a treadmill instead. For them the car is a means to an end; a way to get someplace. So, if you are willing sometimes to suspend disbelief that I am making this all up, I will repay the favor by spending the majority of our short time together teaching you how to get someplace with The Genotype Diet, rather than bludgeoning you with details that you could have easily gotten someplace else.

However, facts do make for the best stories, and I fancy myself a bit of a storyteller. However I do promise to try and keep the terminology down to a reasonable minimum, while keeping the nomenclature at the level where the names of things could at least serve as an interesting name for a pet.

“Here, Allele! Sit! Good doggy! That’s a good Allele!”

Gillian Roberts sent along this link to an interesting article about how the human genome changes with age. Sound like it is right out of The GenoType Diet if you ask me.

Been very busy with the redesign of the NAP website. Part of the problem is that I am Perl/PP/Unix centered and the NAP software and server are ASP Microsoft .NET. No matter, I enjoy learning this kind of stuff.

Generated quite a bit of new content. NAP needed simple FDA compliant explanations for the GenoType Diet formulas, and I wanted to release some additional information on the GenoType profiles that had been prepared for the book but not used. So I combined both jobs these into six monographs:

• The Hunter
• The Gatherer
• The Teacher
• The Explorer
• The Warrior
• The Nomad

Enjoy.

As I've been tinkering with this new blog software, I've become acutely aware of the importance of skins and themes. For the uninitiated, a theme (the more 'proper' wording) or skin (what everyone calls them) are a set of variables that a programmer often adds into a program that allows people to change the appearance of the program in ways that make it more personalized. For example this blog uses a variation of a skin called 'Nautica', which give it a rather pleasing blue palette. To get a better idea, you can browse the various skins for the blogging program Wordpress.

As I went along I began to see the GenoType characterizations as skins of a sort. If blood groups, secretor status an whatnot are the body, then the GenoTypes would be the choice of wardrobe.

For example, look at this graphic:

If we compare the basic type A characterizations and diet, we would see that type A has problems from a mostly tolerant immune system, a greater risk of heart and artery problems, and a greater risk of cancer. Reasonable enough, since that is what the research literature suggests. Type A's have less p53 tumor suppressor activity and their arteries are more prone to inflammation.

However, under simple blood type association, there is really no prioritization of this information.

If we look at the GT3 Teacher program we would see that the diet is skewed more towards cancer protection. It is in the GT3 Teacher that the p53 tumor suppression susceptibility winds up. GT5 Warrior on the other hand, seems to carry the arterial risk; probably because of the two, they are the more thrifty type. Thus if you GenoType as a blood group A Teacher, you will be wearing the 'cancer prevention skin.'

Technically if you are type A you could wear several skins, however if you GenoType as a Teacher, the Teacher skin will be the most therapeutic for you. Same with type O: You might need the 'metabolic syndrome' skin (GT2 Gatherer) more than the 'catabolic inflammatory' skin (GT1 Hunter).

Ditto for the B's and AB's.

Hopefully this will help folks see how values can change when one migrates from the BTD values to the GTD system. Somewhere in the allowable GenoTypes for people with type A blood, there will be that old BTD avoid, however, if it is not in your new GenoType values (or if it flipped to being actually beneficial!) it is because its BTD avoid status was less relevant than the benefits it provides under your new GTD skin.

One of the features that can be of most use when GenoTyping someone is actually one of the hardest to come by: Getting the ABO blood groups of your parents.

Its importance should come as no surprise, since epigenetic changes are largely influenced by the patterns of gene activation and silencing that occur as part of

• The heritable epigenetic component (you start off with the patterns of gene expression that your parents give you)
• The prenatal environment (there are two major bursts of methylation activity in the fetus: at about 8-12 weeks, then again in the last trimester)
• The immediate postnatal environment (these are mostly related to gene expression due to hormones such as growth factors)

In fact one of the studies that got me interested in the largely unrecognized effects of blood groups as a modulator of the epigenetic environment was a study that looked at childhood ear infections and blood groups. However, unlike most epidemiologic correlation type studies, this one looked at the blood group of the child’s mother.

Maternal blood group A gave a relative risk (RR) for intervention of 2.82. The noted occurrence of an attack of acute otitis media (AOM) before the first birthday gave a RR of 6.13. When these two factors were used together, the RR climbed steeply to 26.77.

Now to understand just how strong this association is we should look at exactly what a RR (relative risk) is. Basically it is just the odds (over 1) that something will occur over it being random. An RR of 2 (about the RR of elevated cholesterol causing a heart attack) means that people with elevated cholesterol are twice as likely to get a heart attack as people whose cholesterol levels are more desirable. Thus the study is saying that if you are a kid with an ear infection in the first year of life, and you mother is blood group A, you are 26 times more likely to have a recurrence.

Here is a chart I made which compares relative risks for several common problems and factors associated with that risk. Obviously, this is a very strong association.

Are the effects of having a blood group A mother and getting ear infections the result of some sort of fetal programming? We know that some studies have linked the ABO antigens to cellular differentiation (the process where developing cells move from general embryonic 'germ' types to cells with more specific functions, like a pancreatic or epidermis cell.)

ABH antigen expression was considered as suggestive evidence for the assumption that blood group antigens could serve as early immunomorphologic markers of endothelial differentiation of mesenchymal cells, thus specifying the location of future blood vessels. Extending the conceptual framework of blood group antigens' significance we consider them as being possibly involved in the process of fetal morphogenesis.

In epigenetic terms, we may wind up being more interested in your parent's blood types are that perhaps we need be with yours.

Every once in a while, amid the junk mail, bills and catalogs, I receive a letter which surpasses all prior. In a wonderfully sycophantic endeavor this gentleman writes to ask me for a complete set of my works so he can continue on his mission to educate the Indian public about healthy living. Apparently the gentleman does it free of charge.

Sir, your books are on their way.