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One of the features that can be of most use when GenoTyping someone is actually one of the hardest to come by: Getting the ABO blood groups of your parents.
Its importance should come as no surprise, since epigenetic changes are largely influenced by the patterns of gene activation and silencing that occur as part of
- The heritable epigenetic component (you start off with the patterns of gene expression that your parents give you)
- The prenatal environment (there are two major bursts of methylation activity in the fetus: at about 8-12 weeks, then again in the last trimester)
- The immediate postnatal environment (these are mostly related to gene expression due to hormones such as growth factors)
In fact one of the studies that got me interested in the largely unrecognized effects of blood groups as a modulator of the epigenetic environment was a study that looked at childhood ear infections and blood groups. However, unlike most epidemiologic correlation type studies, this one looked at the blood group of the child’s mother.
Maternal blood group A gave a relative risk (RR) for intervention of 2.82. The noted occurrence of an attack of acute otitis media (AOM) before the first birthday gave a RR of 6.13. When these two factors were used together, the RR climbed steeply to 26.77.
Now to understand just how strong this association is we should look at exactly what a RR (relative risk) is. Basically it is just the odds (over 1) that something will occur over it being random. An RR of 2 (about the RR of elevated cholesterol causing a heart attack) means that people with elevated cholesterol are twice as likely to get a heart attack as people whose cholesterol levels are more desirable. Thus the study is saying that if you are a kid with an ear infection in the first year of life, and you mother is blood group A, you are 26 times more likely to have a recurrence.
Here is a chart I made which compares relative risks for several common problems and factors associated with that risk. Obviously, this is a very strong association.
Are the effects of having a blood group A mother and getting ear infections the result of some sort of fetal programming? We know that some studies have linked the ABO antigens to cellular differentiation (the process where developing cells move from general embryonic 'germ' types to cells with more specific functions, like a pancreatic or epidermis cell.)
ABH antigen expression was considered as suggestive evidence for the assumption that blood group antigens could serve as early immunomorphologic markers of endothelial differentiation of mesenchymal cells, thus specifying the location of future blood vessels. Extending the conceptual framework of blood group antigens' significance we consider them as being possibly involved in the process of fetal morphogenesis.
In epigenetic terms, we may wind up being more interested in your parent's blood types are that perhaps we need be with yours.
Every once in a while, amid the junk mail, bills and catalogs, I receive a letter which surpasses all prior. In a wonderfully sycophantic endeavor this gentleman writes to ask me for a complete set of my works so he can continue on his mission to educate the Indian public about healthy living. Apparently the gentleman does it free of charge.
Sir, your books are on their way.
I was smiling at the gentleman from India who wrote to you. I'm working with a retired Doctor who has taken upon himself to test and educate a small village in South India. It's also my home town. I'm collecting data and will eventually post it on the forum...but that's a long way off from now.
I just wanted to say that your dedication to improving people's lives never, ever fail to amaze me. Now, if only you could just turn your attention to South India, you will be amazed to find a totally new terrain to play on. That, I suppose, would require you to have 48hrs per day as opposed to the 24hrs(barely) that you now have ;-)!
Wondering if this has anything to do with As and milk troubles. Dairy has long been linked with extra mucus and ear infections. Hmmmm.
Within 48 hours my hypoglycemia evaporated, and my husband's snoring and "allergies" all but disappeared. Both B+, we were thrilled.
Since then, I have counseled hundreds of clients, employees, family members and friends in many states and in Europe. The second question I ask is "What is your blood type?" (the first being, "How can I help you?") Yes, I have taken heat from fellow professionals, but my hospital administrators support and refer me, so no worries. I am probably responsible for the sale of several hundred of your books--for which I will happily await my heavenly crown--all because good health IS as easy as cooperating with one's genetics. Plus, it's fun. My clients with diabetes are achieving tremendous success, discontinuing meds (per their MD), and saying bye-bye to complications because of R4YT eating. Sure makes me look good!
Clients with all the "usual" autoimmune disorders are riding bikes and back to work. Those with gi disorders are happy you are alive, and friends' children no longer suffer with continual infections. Must be some kinda magic...
Kudos to you for the next step-genotypes! My professional association is just beginning its acceptance of nutrigenomics--someday they will embrace you (like they did Linus Pauling), but in the meantime I will be on the blade's edge with your latest information.
Thank you for your scholarship, curiosity, persistence, and arid, dusty humor. I have enjoyed your site(s) for years, and have appreciated its evolution as new research unfolds. I anticipate a wonderful future and will do all I can to promote you and yours to fellow professionals and to all my clients, friends and family.
With joy & gratitude,
Robin Waltenberger, RD/LD
Send me your email address or mailing address, so I can send it to you.
Thank You Dr.D.
Czy moglabym napisac po polsku?
Thanks for helping us beat the odds!
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