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STUDY: A genetic study of vitamin D deficiency rickets: 2-sex differences and ABO typing.
JOURNAL: J Egypt Public Health Assoc 1992;67(1-2):213-22
AUTHORS: el-Kholy MS, Abdel Mageed FY, Farid FA.
ABSTRACT: In a further attempt to study the role of genetics in vitamin D deficiency rickets, 400 rachitic infants randomly chosen and aged from 6 months to 2 years (14.3 +/- 3.5 months) were investigated for sex differences and ABO typing. A significant (P < 0.001) predominance of the male sex was found, sex ratio being 1.43. Blood group A was significantly (P < 0.001) associated with rachitic patients whether males or females. Alkaline phosphatase values were significantly (P < 0.01) higher in male infants 91% of them had levels above 30 K.A. units, while the corresponding percentage of girls was 72%. This indicates that the disease is more severe among males. The study gives added support for the belief that there is a genetic factor in nutritional rickets.
COMMENTARY: As with several other studies highlighted this week on Ask Dr. D'Adamo, ABO blood type genetics seem to be heavily intertwined with the difference sin the sex ratio. In this case, rickets (a bone softening disease that is the result of vitamin D defficiency) blood group A and males. I find this interesting in light of my own results in large scale studies on personality analysis inventory (Myers-Briggs) and ABO blood group. My studies show a correlation of high significance (like the study above, P < 0.001) with extroversion and blood group O, but only in women. Also, there was a identical correlation of blood group A and introversion, but in this case only in men.